scholarly journals Proton beam radiotherapy in the management of uveal melanoma: Clinical experience in Scotland

2008 ◽  
pp. 49 ◽  
Author(s):  
Samir Aziz
Keyword(s):  
Proton Beam ◽  
Uveal Melanoma ◽  
Clinical Experience ◽  
Proton Beam Radiotherapy

scholarly journals MR Imaging–Pathologic Correlation of Uveal Melanomas Undergoing Secondary Enucleation after Proton Beam Radiotherapy

2021 ◽  
Vol 11 (9) ◽  
pp. 4310
Author(s):  
Pietro Valerio Foti ◽  
Corrado Inì ◽  
Mario Travali ◽  
Renato Farina ◽  
Stefano Palmucci ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Proton Beam ◽  
Uveal Melanoma ◽  
Vitreous Hemorrhage ◽  
Nerve Degeneration ◽  
Proton Beam Radiotherapy ◽  
Iris Neovascularization ◽  
Weighted Sequences ◽  
Histopathologic Findings ◽  
Optic Nerve Degeneration

Background: Currently, radiotherapy represents the most widely employed therapeutic option in patients with uveal melanoma. Although the effects of proton beam radiotherapy on uveal melanoma end ocular tissues have been histologically documented, their appearance at MR imaging is still poorly understood. The purpose of our study was to elucidate the magnetic resonance (MR) semiotics of radiotherapy-induced changes to neoplastic tissues and ocular structures in patients with uveal melanoma undergoing secondary enucleation after proton beam radiotherapy. Methods: Nine patients with uveal melanoma who had undergone proton beam radiotherapy, MR imaging, and subsequent secondary enucleation were retrospectively selected. The histopathologic findings evaluated for irradiated tumors were necrosis, fibrosis, and viable tumor, while the histopathologic findings evaluated for extratumoral ocular/periocular tissues were radiation-related intraocular inflammation, vitreous hemorrhage, optic nerve degeneration, iris neovascularization, and periocular fibrotic adhesions. On MR images, the appearance of the abovementioned histologic features was assessed on conventional and diffusion-weighted sequences. Results: T2-weighted sequences performed better in detecting radiation-induced necrosis, fibrosis, optic nerve degeneration, and periocular fibrotic adhesions. T1-weighted sequences were preferable for identifying cataracts, vitreous hemorrhage, and inflammatory complications. Contrast-enhanced T1-weighted sequences were irreplaceable in assessing iris neovascularization, and in confirming inflammatory complications. Conclusions: In the light of their increasing role in the multidisciplinary management of patients with uveal melanoma, radiologists should be aware of the MR appearance of the effects of radiotherapy on neoplastic and ocular tissue, in order to improve the accuracy of follow-up MR examinations.

scholarly journals Proton beam radiotherapy for uveal melanoma

2015 ◽  
Vol 10 (6) ◽  
pp. 577-585
Author(s):  
Armin R Afshar ◽  
Jay M Stewart ◽  
Andrew A Kao ◽  
Kavita K Mishra ◽  
Inder K Daftari ◽  
...  
Keyword(s):  
Proton Beam ◽  
Uveal Melanoma ◽  
Proton Beam Radiotherapy

OCT changes in peri-tumour normal retina following ruthenium-106 and proton beam radiotherapy for uveal melanoma

2020 ◽  
pp. bjophthalmol-2019-314802
Author(s):  
Rumana Hussain ◽  
Florian Moritz Heussen ◽  
Heinrich Heimann
Keyword(s):  
Proton Beam ◽  
Uveal Melanoma ◽  
Choroidal Melanoma ◽  
Retinal Layer ◽  
Proton Beam Radiotherapy ◽  
Retinal Layers ◽  
Spectral Domain Oct ◽  
Ruthenium 106 Brachytherapy ◽  
Safety Margins ◽  
Plaque Brachytherapy

IntroductionUveal melanoma is most commonly treated with radiotherapy, destroying the tumour cells with adequate safety margins and limiting collateral damage to surrounding structures to preserve maximal vision. We used optical coherence tomography (OCT) to study the effects of radiotherapy on the retina.MethodsPatients with posteriorly located choroidal melanoma treated with proton beam radiotherapy (PBR) and ruthenium-106 brachytherapy between January 2010 and June 2014 underwent spectral domain OCT.ResultsImages of 32 patients following ruthenium-106 brachytherapy and 44 patients following proton beam teletherapy were analysed. Following plaque brachytherapy, an early marked disruption of the outer retinal layers could be observed in 30 cases (94%) with retinal atrophy evident in 26 cases (81%). In contrast, the images from patients who underwent PBR showed subtle outer retinal layer change with 16 cases (36%) showing some inner-outer segment junction disruption by 6 months and 63%  by 24 months with minimal atrophy. In cases with tumours <2 mm from the fovea, the visual loss was significantly less at 6 and 12 months in the proton beam group.ConclusionIn comparison to ruthenium-106 plaque brachytherapy, PBR leads to more subtle and slower changes in the outer retinal layers enabling retention of visual function for longer. The difference in dosing regime and dose distribution across the tumour is likely to be causative for this structural differential.

Proton beam radiotherapy for uveal melanoma: Results of Curie Institut–Orsay Proton Therapy Center (ICPO)

2006 ◽  
Vol 65 (3) ◽  
pp. 780-787 ◽  
Author(s):  
Rémi Dendale ◽  
Livia Lumbroso-Le Rouic ◽  
Georges Noel ◽  
Loïc Feuvret ◽  
Christine Levy ◽  
...  
Keyword(s):  
Proton Beam ◽  
Uveal Melanoma ◽  
Proton Therapy ◽  
Proton Beam Radiotherapy ◽  
Therapy Center

scholarly journals Long-Term Visual Outcomes for Small Uveal Melanoma Staged T1 Treated by Proton Beam Radiotherapy

Cancers ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1047 ◽  
Author(s):  
Adélaïde Toutée ◽  
Martina Angi ◽  
Sylvain Dureau ◽  
Christine Lévy-Gabriel ◽  
Livia Lumbroso-Le Rouic ◽  
...  
Keyword(s):  
Proton Beam ◽  
Optic Disc ◽  
Uveal Melanoma ◽  
Early Stage ◽  
Tumor Control ◽  
Proton Beam Radiotherapy ◽  
Visual Outcomes ◽  
The Mean

There is increasing evidence of the survival benefit of treating uveal melanoma in an early stage, however it is important to discuss with the patient the associated risk of visual loss. We investigated visual outcomes for uveal melanomas staged T1 (T1UM) treated by proton beam radiotherapy (PBR) as a function of their distance to fovea-optic disc. This retrospective study included a cohort of 424 patients with T1UM treated with PBR between 1991 and 2010 with at least a 5-year follow-up. Visual acuity (VA) was analyzed for patients with posterior edge of tumor located at ≥3 mm (GSup3) or <3 mm (GInf3) from fovea-optic disc. The mean follow-up duration was 122 months, no tumor recurrence was observed. The mean baseline and final VA were 20/25 and 20/32 for GSup3 (n = 75), and 20/40 and 20/80 for GInf3 (n = 317) respectively. The frequency of a 20/200 or greater visual conservation was 93.2%(CI95%:87.7–99.1) and 60.1%(CI95%:54.9–65.9) for GSup3 and GInf3 respectively. This difference between groups was statistically significant (p < 0.001). The risk factors for significant VA loss (less than 20/200) were GInf3 location (p < 0.001), tumor touching optic disc (p = 0.04), initial VA inferior to 20/40 (p < 0.001), documented growth (p = 0.002), and age greater than 60 years (p < 0.001). In summary, PBR for T1UM yields excellent tumor control and good long-term visual outcomes for tumors located ≥3 mm from fovea-optic disc.

Eye retention after proton beam radiotherapy for uveal melanoma

2003 ◽  
Vol 55 (4) ◽  
pp. 867-880 ◽  
Author(s):  
Emmanuel Egger ◽  
Leonidas Zografos ◽  
Ann Schalenbourg ◽  
Donata Beati ◽  
Terence Bhringer ◽  
...  
Keyword(s):  
Proton Beam ◽  
Uveal Melanoma ◽  
Proton Beam Radiotherapy

scholarly journals Proton beam radiotherapy of uveal melanoma

2013 ◽  
Vol 27 (3) ◽  
pp. 151-157 ◽  
Author(s):  
Bertil Damato ◽  
Andrzej Kacperek ◽  
Doug Errington ◽  
Heinrich Heimann
Keyword(s):  
Proton Beam ◽  
Uveal Melanoma ◽  
Proton Beam Radiotherapy

PROTON BEAM RADIOTHERAPY FOR UVEAL MELANOMA: RESULTS IN OUR CENTER

2009 ◽  
Vol 92 ◽  
pp. S227
Author(s):  
H. Mammar ◽  
J.P. Caujolle ◽  
J. Herault ◽  
G. Angellier ◽  
P. Mandrillon ◽  
...  
Keyword(s):  
Proton Beam ◽  
Uveal Melanoma ◽  
Proton Beam Radiotherapy

scholarly journals Local tumour control and radiation side effects for fractionated stereotactic photon beam radiotherapy compared to proton beam radiotherapy in uveal melanoma

2021 ◽  
Vol 157 ◽  
pp. 219-224
Author(s):  
Jackelien G.M. van Beek ◽  
Wishal D. Ramdas ◽  
Martina Angi ◽  
Caroline M. van Rij ◽  
Nicole C. Naus ◽  
...  
Keyword(s):  
Side Effects ◽  
Proton Beam ◽  
Uveal Melanoma ◽  
Photon Beam ◽  
Proton Beam Radiotherapy ◽  
Tumour Control ◽  
Local Tumour Control ◽  
Local Tumour ◽  
Radiation Side Effects

Baerveldt shunts in the treatment of glaucoma secondary to anterior uveal melanoma and proton beam radiotherapy

2012 ◽  
Vol 96 (8) ◽  
pp. 1104-1107 ◽  
Author(s):  
Eamon Sharkawi ◽  
Justyna D Oleszczuk ◽  
Ciara Bergin ◽  
Leonidas Zografos
Keyword(s):  
Proton Beam ◽  
Uveal Melanoma ◽  
Proton Beam Radiotherapy
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