The efficacy of bromfenac ophthalmic solution 0.07% dosed once daily in achieving zero-to-trace anterior chamber cell severity following cataract surgery

Patients with pseudoexfoliation syndrome (PEX) experience more intense inflammation after phacoemulsification compared to routine cataracts. The effect of topical nonsteroidal anti-inflammatories (NSAIDs) in eyes with PEX have not been studied to date. Laser flare photometry was used in this study to evaluate subtle amounts of postoperative inflammation. The addition of bromfenac to dexamethasone ophthalmic solution significantly reduced anterior chamber inflammation after cataract surgery in PEX when compared to dexamethasone alone. Postoperative macular thickness at optical coherence tomography (OCT) was also positively affected by the addition of topical bromfenac.

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Faculty of 1000 evaluation for Bromfenac Ophthalmic Solution 0.07% (Prolensa) Dosed Once Daily for Cataract Surgery: Results of 2 Randomized Controlled Trials.

F1000 - Post-publication peer review of the biomedical literature ◽

10.3410/f.718105565.793486565 ◽

2013 ◽

Author(s):

George Beiko

Keyword(s):

Cataract Surgery ◽

Randomized Controlled Trials ◽

Ophthalmic Solution ◽

Controlled Trials ◽

Once Daily ◽

Randomized Controlled

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A once-daily ophthalmic solution of bromfenac reduces ocular pain and inflammation after cataract surgery,

Inpharma Weekly ◽

10.2165/00128413-200715750-00022 ◽

2007 ◽

Vol &NA; (1575) ◽

pp. 11

Author(s):

&NA;

Keyword(s):

Cataract Surgery ◽

Ophthalmic Solution ◽

Ocular Pain ◽

Once Daily

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Bromfenac Ophthalmic Solution 0.07% Dosed Once Daily for Cataract Surgery

Ophthalmology ◽

10.1016/j.ophtha.2013.07.006 ◽

2014 ◽

Vol 121 (1) ◽

pp. 25-33 ◽

Cited By ~ 16

Author(s):

Thomas R. Walters ◽

Damien F. Goldberg ◽

James H. Peace ◽

James A. Gow

Keyword(s):

Cataract Surgery ◽

Ophthalmic Solution ◽

Once Daily

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The Effects of Rimexolone 1% in Postoperative Inflammation after Cataract Extraction. A Double-Masked Placebo-Controlled Study

European Journal of Ophthalmology ◽

10.1177/112067219800800105 ◽

1998 ◽

Vol 8 (1) ◽

pp. 16-21 ◽

Cited By ~ 18

Author(s):

A. Bron ◽

P. Denis ◽

T. C. Hoang-Xuan ◽

C. Boureau-Andrieux ◽

P. Crozafon ◽

...

Keyword(s):

Cataract Surgery ◽

Anterior Chamber ◽

Clinical Signs ◽

Ophthalmic Solution ◽

Cataract Extraction ◽

Controlled Study ◽

Eye Drops ◽

Severity Scores ◽

Lens Implantation ◽

Ocular Pressure

Aim A multicentre, randomized, placebo-controlled double-masked study was conducted to assess the efficacy and safety of Rimexolone 1% eye drops in reducing inflammation after cataract surgery and intra-ocular lens implantation. Methods Rimexolone 1% (124 patients) or placebo (58 patients) was given, four times a day for 14 days starting 22-34 hours after surgery. All patients also received tobramycin 0.3% four times a day for 7 days. The clinical signs of ocular inflammation were recorded on days 1, 3, 8, 15 and 17 or 18. Results Rimexolone 1% markedly decreased the mean inflammation severity scores, and the sum of clinical assessments of cells and flare in the anterior chamber compared with placebo at each assessment. In addition, the percentage of patients with no anterior chamber inflammation was significantly higher with Rimexolone 1% than with the placebo at each assessment. All these results were statistically significant. Intra-ocular pressure did not rise after treatment with Rimexolone 1%. Conclusions The results suggest that Rimexolone 1% ophthalmic solution is an effective and safe steroidal anti-inflammatory agent for topical use following cataract surgery and intraocular lens implantation.

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Fixed-Dose Combination of 0.1% Diclofenac plus 0.3% Tobramycin Ophthalmic Solution for Inflammation after Cataract Surgery: A Randomized, Comparative, Active Treatment-Controlled Trial

European Journal of Ophthalmology ◽

10.1177/112067219800800310 ◽

1998 ◽

Vol 8 (3) ◽

pp. 173-178 ◽

Cited By ~ 9

Author(s):

R.I. Barraquer ◽

J.P. ÁLvarez de Toledo ◽

D. Montané ◽

R.M. Escoto ◽

C. Garcia Torres ◽

...

Keyword(s):

Cell Count ◽

Anterior Chamber ◽

Ophthalmic Solution ◽

Cataract Extraction ◽

Fixed Dose Combination ◽

Fixed Dose ◽

Anterior Chamber Cell ◽

Lens Implantation ◽

Dose Combination ◽

Ocular Tolerability

Purpose To assess the efficacy, tolerance, and ocular tolerability of a fixed-dose combination of 0.1% diclofenac plus 0.3% tobramycin ophthalmic solution compared with 0.1% diclofenac (Voltaren®) and 0.3% tobramycin (Tobrex®) in patients undergoing cataract extraction by either nuclear expression (extracapsular) or ultrasound-assisted aspiration (phacoemulsification) with intraocular lens implantation. Methods Eighty-eight patients undergoing cataract extraction with intraocular lens implantation participated in a randomized, parallel, observer-masked trial, in which the clinical usefulness of a fixed-dose combination of 0.1% diclofenac plus 0.3% tobramycin ophthalmic solution, two eyedrops every 6 hours (n=44) was compared with Voltaren® and Tobrex®, one drop of each every 6 hours (n=44) in a 22-day course. Efficacy was assessed from changes of the sum of anterior chamber cell count plus flare, conjunctival hyperemia and edema, and ciliary congestion, by means of slit lamp biomicroscopy on days 1, 7, 14, and 21. Tolerance and ocular tolerability were assessed by recording intraocular pressure (IOP), side effects, and the patient's and investigator's opinions. Results Anterior chamber cell count plus flare showed no differences in the two treatment groups at any evaluation point. The study treatment was associated with a significantly higher score for conjuncitval edema on day 1 (p=0.015), conjuncitval hyperemia on day 14 (p=0.009) and anterior chamber cell count on day 21 (p=0.04), but these differences had no clinical relevance. No side effects related to the study treatment were recorded. Conclusions Efficacy, tolerance, and ocular tolerability of a fixed-dose combination of 0.1% diclofenac plus 0.3% tobramycin ophthalmic solution were comparable to Voltaren® plus Tobrex® for the control of anterior chamber inflammation after cataract surgery, with the advantage that both active principles are supplied in a single container.

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Faculty Opinions recommendation of Anterior chamber flare after femtosecond laser-assisted cataract surgery.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718030979.793486548 ◽

2013 ◽

Author(s):

Iqbal Ahmed ◽

Devesh Varma

Keyword(s):

Femtosecond Laser ◽

Cataract Surgery ◽

Anterior Chamber ◽

Anterior Chamber Flare

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Urrets-Zavalia Syndrome Following Cataract Surgery

Case Reports in Ophthalmology ◽

10.1159/000513959 ◽

2021 ◽

pp. 659-663

Author(s):

Shimon Kurtz ◽

Maayan Fradkin

Keyword(s):

Intraocular Pressure ◽

Case Report ◽

Cataract Surgery ◽

Anterior Chamber ◽

Inflammatory Reaction ◽

Intraocular Lens Implantation ◽

Postoperative Course ◽

Lens Implantation ◽

The Right

We describe a case of Urrets-Zavalia syndrome (UZS) in a healthy 56-year-old woman who underwent femtosecond-assisted phacoemulsification with intraocular lens implantation in both eyes. One month after an uneventful postoperative course in the left eye, the right eye was operated. Dilated pupil which was nonreactive to light appeared on day 21 postoperatively. This was discovered upon examination following anterior chamber inflammatory reaction which occurred 2 weeks following her surgery. Our case report emphasizes the importance and danger in developing UZS even if the reaction in the anterior chamber does not occur immediately after surgery. In addition, the importance of intraocular pressure follow-up in the period after UZS is acknowledged.

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Intraocular Pressure Reduction after Femtolaser Assisted Cataract Surgery and Its Association with the Use of Ultrasound

Medicina ◽

10.3390/medicina57050437 ◽

2021 ◽

Vol 57 (5) ◽

pp. 437

Author(s):

Hana Abouzeid ◽

Walter Ferrini ◽

Murielle Bochud

Keyword(s):

Intraocular Pressure ◽

Linear Regression ◽

Cataract Surgery ◽

Anterior Chamber ◽

Anterior Chamber Depth ◽

Multiple Linear Regression Model ◽

Study Data ◽

Department Of Ophthalmology ◽

Duration Of Surgery ◽

Ocular Pressure

Background and Objectives: To quantify the change in intraocular pressure (IOP) after phacoemulsification in patients having undergone femtolaser assisted cataract surgery (FLACS), and study the influence of the use of ultrasound on this change. Setting: Jules-Gonin Eye Hospital, University Department of Ophthalmology, Lausanne, Switzerland. Materials and Methods: Interventional study. Methods: All consecutive cases operated with FLACS and with complete data for the studied parameters were selected for inclusion in the study. Data had been prospectively collected and was analysed retrospectively. Linear regression was performed to explore the association of change in IOP with time of measure, ultrasound use, sex, age, and duration of surgery. Results: There was a mean decrease in intraocular pressure of 2.5 mmHg (CI 95% −3.6; −1.4, p < 0.001) postoperatively. No association between the change in intraocular pressure and ultrasound time or effective phaco time was observed when the data were analyzed one at a time or in a multiple linear regression model. There was no association with sex, age, nuclear density, presence of pseudoexfoliation, duration of surgery, and time of ocular pressure measurement. Eyes with preoperative IOP ≥ 21 mmHg had a more significant IOP reduction after surgery (p < 0.0001) as did eyes with an anterior chamber depth <2.5 mm (p = 0.01). Conclusion: There was a decrease in intraocular pressure six months after FLACS in our study similar to that in the published literature for standard phacoemulsification. The use of ultrasound may not influence the size of the decrease, whereas the preoperative IOP and anterior chamber depth do. FLACS may be as valuable as standard phacoemulsification for cases where IOP reduction is needed postoperatively.

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