scholarly journals Efficacy of sorafenib after liver transplantation in patients with primary hepatic carcinoma exceeding the Milan criteria: a preliminary study

2012 ◽  
pp. 457 ◽  
Author(s):  
Ivan Tjong-a-Hung
Keyword(s):  
Liver Transplantation ◽  
Milan Criteria ◽  
Hepatic Carcinoma ◽  
Primary Hepatic Carcinoma ◽  
Preliminary Study

scholarly journals Efficacy of sorafenib after liver transplantation in patients with primary hepatic carcinoma exceeding the Milan criteria: a preliminary study [Expression of concern]

2020 ◽  
Vol Volume 13 ◽  
pp. 3289-3290
Author(s):  
Lei Huang ◽  
Guang-ming Li ◽  
Ji-ye Zhu ◽  
Zhao Li ◽  
Tao Li ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Milan Criteria ◽  
Hepatic Carcinoma ◽  
Primary Hepatic Carcinoma ◽  
Preliminary Study

scholarly journals Efficacy of sorafenib after liver transplantation in patients with primary hepatic carcinoma exceeding the Milan criteria: a preliminary study [Expression of concern] [Erratum]

2020 ◽  
Vol Volume 13 ◽  
pp. 4019-4020
Author(s):  
Lei Huang ◽  
Guang-ming Li ◽  
Ji-ye Zhu ◽  
Zhao Li ◽  
Tao Li ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Milan Criteria ◽  
Hepatic Carcinoma ◽  
Primary Hepatic Carcinoma ◽  
Preliminary Study

scholarly journals Dynamic Metabolomics Study of the Bile Acid Pathway During Perioperative Primary Hepatic Carcinoma Following Liver Transplantation

2020 ◽  
Vol 25 ◽  
Author(s):  
Weiguo Sui ◽  
Qing Gan ◽  
Fuhua Liu ◽  
Minglin Ou ◽  
Bingguo Wang ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Bile Acid ◽  
Hepatic Carcinoma ◽  
Primary Hepatic Carcinoma ◽  
Metabolomics Study ◽  
Acid Pathway

scholarly journals The differentially expressed circular ribonucleic acids of primary hepatic carcinoma following liver transplantation as new diagnostic biomarkers for primary hepatic carcinoma

Tumor Biology ◽  
2018 ◽  
Vol 40 (4) ◽  
pp. 101042831876692 ◽  
Author(s):  
Weiguo Sui ◽  
Qing Gan ◽  
Fuhua Liu ◽  
Huaizhou Chen ◽  
Junfu Liu ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Normal Control ◽  
Ribonucleic Acid ◽  
Expression Level ◽  
Hepatic Carcinoma ◽  
Post Transplantation ◽  
Ribonucleic Acids ◽  
Expression Levels ◽  
Primary Hepatic Carcinoma ◽  
Normal Controls

Recent studies have shown that circular ribonucleic acids have differential expression in some diseases. This study compared the expression levels of five circular ribonucleic acids between patients of primary hepatic carcinoma following liver transplantation and healthy individuals for searching a new diagnostic biomarker about primary hepatic carcinoma. We chose differentially expressed targeted circular ribonucleic acids according to fold change ≥2.0 or ≤–2.0 between circular ribonucleic acids microarray of perioperative liver transplantation and normal controls. Then we used the Arraystar home-made micro-ribonucleic acid target prediction software based on TargetScan and miRanda to predict circular ribonucleic acid/micro-ribonucleic acid interactions. And we assess the expression levels of hsa_circ_100571, hsa_circ_400031, hsa_circ_102032, hsa_circ_103096, and hsa_circ_102347 in the peripheral blood of normal controls and liver transplantation patients before transplantation and on the first, third, and seventh days after transplantation by real-time quantitative polymerase chain reaction. We chose five circular ribonucleic acids, two of which have been correlated with micro-ribonucleic acid–related carcinoma recurrence after liver transplantation, hepatocellular carcinoma and analyzed their expression with 2–△△Ct method. The expression level of hsa_circ_100571 and hsa_circ_400031 on day 1 after liver transplantation was higher than pre-transplantation (p < 0.01), and these levels showed a declining trend on post-transplantation. The expression level of hsa_circ_102032 and hsa_circ_103096 on day 1 after liver transplantation was lower than pre-transplantation (p < 0.01) and decreased on post-transplantation. There were the significantly different expressions between the post-transplantation day 7 and normal control (p < 0.01). The expression level of hsa_circ_102347 on day 1 after liver transplantation was lower than pre-transplantation (p < 0.01). This expression showed a declining trend on post-transplantation, and the postoperative day 7 level was similar to normal control (p > 0.05). Five types of circular ribonucleic acid–related micro-ribonucleic acids had varying degrees of upregulation and downregulation between perioperative transplantation of primary hepatic carcinoma patients and normal controls; the hsa_circ_102347 is most likely to have association with primary hepatic carcinoma.

scholarly journals Occurence of acute myeloid leukemia after primary hepatic carcinoma in a patient who had liver transplantation

2020 ◽  
Vol 42 ◽  
pp. 72-73 ◽  
Author(s):  
C. Coskun ◽  
S. Unal ◽  
A. Uner ◽  
T. Aksu ◽  
S. Aytac ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Hepatic Carcinoma ◽  
Primary Hepatic Carcinoma ◽  
Acute Myeloid

Effect of conversion to sirolimus-based immunosuppression on tumor recurrence after liver transplantation for hepatocellular carcinoma beyond the Standard Milan Criteria

2013 ◽  
Vol 32 (6) ◽  
pp. 642-645 ◽  
Author(s):  
Li-kui FENG ◽  
Zhi-jia NI ◽  
Shao-hua SONG ◽  
Feng LIN ◽  
Hong FU ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Tumor Recurrence ◽  
Milan Criteria

scholarly journals The Treatment Effect of Liver Transplantation versus Liver Resection for HCC: A Review and Future Perspectives

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3730
Author(s):  
Berend R. Beumer ◽  
Roeland F. de Wilde ◽  
Herold J. Metselaar ◽  
Robert A. de Man ◽  
Wojciech G. Polak ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Liver Resection ◽  
Early Stage ◽  
Disease Free Survival ◽  
Milan Criteria ◽  
Term Survival ◽  
Equal Distribution ◽  
Intention To Treat ◽  
Treat Analysis

For patients presenting with hepatocellular carcinoma within the Milan criteria, either liver resection or liver transplantation can be performed. However, to what extent either of these treatment options is superior in terms of long-term survival is unknown. Obviously, the comparison of these treatments is complicated by several selection processes. In this article, we comprehensively review the current literature with a focus on factors accounting for selection bias. Thus far, studies that did not perform an intention-to-treat analysis conclude that liver transplantation is superior to liver resection for early-stage hepatocellular carcinoma. In contrast, studies performing an intention-to-treat analysis state that survival is comparable between both modalities. Furthermore, all studies demonstrate that disease-free survival is longer after liver transplantation compared to liver resection. With respect to the latter, implications of recurrences for survival are rarely discussed. Heterogeneous treatment effects and logical inconsistencies indicate that studies with a higher level of evidence are needed to determine if liver transplantation offers a survival benefit over liver resection. However, randomised controlled trials, as the golden standard, are believed to be infeasible. Therefore, we suggest an alternative research design from the causal inference literature. The rationale for a regression discontinuity design that exploits the natural experiment created by the widely adopted Milan criteria will be discussed. In this type of study, the analysis is focused on liver transplantation patients just within the Milan criteria and liver resection patients just outside, hereby ensuring equal distribution of confounders.

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