scholarly journals Prognostic assessment of lung cancer risk under combined action of radon and smoking using an additive-multiplicative risk model

2021 ◽  
Vol 14 (3) ◽  
pp. 41-55
Author(s):  
M. V. Zhukovsky ◽  
I. V. Yarmoshenko ◽  
A. D. Onishchenko ◽  
G. P. Malinovsky
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Radon Concentration ◽  
Mixed Model ◽  
Lung Cancer Risk ◽  
Concentration Level ◽  
Indoor Radon ◽  
Total Mortality ◽  
Indoor Radon Concentration ◽  
Combined Action

An application of geometric mixed additive-multiplicative models for lung cancer risk modeling under combined action of radon and smoking is justified in this paper. The geometric mixed model allows: 1) to reduce the discrepancies between estimates of the lung cancer risk for males and females, 2) to predict the population risk under condition of the varying smoking prevalence and changing average indoor radon concentration level. Using the geometric mixed model, the calculation of the lung cancer risks for the Russian Federation population was carried out for different percentages of smokers among the population, an increase in life expectancy, and a change in the average radon concentration level in residential buildings. Assuming that currently rounded average indoor radon concentration in Russia is 50 Bq/m3, the contribution of radon to total mortality in 2009 was 0.46% and 0.20% for male and female, respectively. Modeling has shown that the effect of lung cancer mortality reducing due to the predicted decrease in the proportion of smoking population will partly be offset by an increase in the realization of lung cancer risk with the life expectancy increase. For a hypothetical situation, when the entire population maintain a healthy lifestyle and mortality from cardiovascular, oncological, infectious diseases, diseases of the respiratory tract and from external causes has significantly decreased, the contribution of radon exposure to total mortality will increase to about 0.8%. If the average level of radon in buildings will increase due to energy-efficient technologies widespread implementation in building construction, the contribution of radon to total mortality will be even more noticeable. 

Lung cancer risk from indoor radon

The Lancet ◽  
1996 ◽  
Vol 348 (9042) ◽  
pp. 1662-1663 ◽  
Author(s):  
Anssi Auvinen
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Indoor Radon

The true size of the lung cancer risk from indoor radon: hidden behind a smoke screen?

2002 ◽  
Vol 1225 ◽  
pp. 253-258 ◽  
Author(s):  
Jürgen Conrady ◽  
Karl Martin ◽  
Jürgen Lembcke ◽  
Horst Martin
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Indoor Radon

scholarly journals Construction a process to measurement the indoor radon concentration

2013 ◽  
Vol 16 (3) ◽  
pp. 53-60
Author(s):  
Hien Thi To ◽  
Nguyen Thao Nguyen ◽  
Huy Huu Duong
Keyword(s):  
Lung Cancer ◽  
Exposure Time ◽  
Radon Concentration ◽  
Indoor Radon ◽  
Construction Process ◽  
Indoor Radon Concentration ◽  
Radon Exposure ◽  
Indoor Location ◽  
Radon Inhalation ◽  
Radon Concentrations

Radon is a naturally radioactive gas , but it causes lung cancer to humans. The risk of lung cancer due to radiation depends on the amount of radon inhalation and radon exposure time. In Vietnam, radon concentrations are usually determined by RAD7, however RAD7 just showed the immediate values of radon, and have to regularly calibrate it. The construction process to determine the accumulates indoor radon concentration by detector CR- 39 in order to be widely used in the study of environmental pollution, especially the study of health risks of radon for humans and mapping radon pollution. Detector CR - 39 is placed in a 7 cm - plastic holder, and in exposure time, the holders were covered with glass fiber filter paper ∅ 47mm on the bottom of the detector to avoid the exposure of dust. Then it is hung in the indoor location as Vietnam Standard 7889:2008. After 3 months, holders are returned to a laboratory, and CR - 39 will be soaked in 6M NaOH at 700C. Indoor radon concentrations will be proportional to the density traces obtained on CR-39. The study uses an radium 226 source of the NIST (National Institute for Standards and Technology) with the released radon coefficient : f = 0.891 ± 0.015. Results show the calibration factor K is 4.533 ± 0.218 [(Bq.m-3. day)]/(tracks / CR-39)]. Using K factor, we can determine the cumulative indoor radon concentration.

scholarly journals A 10-year follow-up study of yearly indoor radon measurements in homes, review of other studies and implications on lung cancer risk estimates

2021 ◽  
Vol 762 ◽  
pp. 144150
Author(s):  
Sara Antignani ◽  
Gennaro Venoso ◽  
Marco Ampollini ◽  
Mario Caprio ◽  
Carmela Carpentieri ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Indoor Radon ◽  
Follow Up Study ◽  
Risk Estimates ◽  
Radon Measurements

scholarly journals Study of Lung Cancer Hazard Due to Radiate Radon Gas for Two Factories in Industrial Region (Shaikh Omar) of Baghdad Governorate

2020 ◽  
Vol 33 (4) ◽  
pp. 27
Author(s):  
N. A. Mohammed ◽  
S. A. Ebrahiem
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Radon Concentration ◽  
Lung Cancer Risk ◽  
Industrial Region ◽  
Radon Gas

During the winter, in the industry region (Shaikh Omer) and by applying a passive radon detector (CR-39), lung cancer risk has been measured in twelve rooms of different workshops of two old factories in this site. The radon concentration is ranged from (123.345 Bq/m3) to (328.985 Bq/m3) with an average of (244.19±61.52 Bq/m3). Lung cancer risk ranged from 55.993 to 149.346 per million people and with an average of (110.855 per million people) which were lower than the recommended values (170-230 per million people), so there was no cancer risk on workers in these locations.

Indoor radon exposure and lung cancer risk: a meta-analysis of case-control studies

2017 ◽  
Vol 6 (S5) ◽  
pp. S934-S943 ◽  
Author(s):  
Carmine Garzillo ◽  
Mariagabriella Pugliese ◽  
Filomena Loffredo ◽  
Maria Quarto
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Indoor Radon ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Radon Exposure

IDENTIFICATION OF NOVEL BIOMARKERS FOR LUNG CANCER RISK IN HIGH LEVELS OF RADON BY PROTEOMICS: A PILOT STUDY

2019 ◽  
Vol 184 (3-4) ◽  
pp. 496-499
Author(s):  
N Autsavapromporn ◽  
N Dukaew ◽  
A Wongnoppavich ◽  
B Chewaskulyong ◽  
S Roytrakul ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Indoor Radon ◽  
Research Direction ◽  
Healthy Controls ◽  
Natural Radiation ◽  
Lung Cancer Patients ◽  
Proteomic Approach ◽  
Novel Biomarkers

AbstractRadon is the second most important risk factor for lung cancer after tobacco smoking. In Chiang Mai, Thailand, the values of indoor radon activity concentrations are considerably higher than global average values and it is a highest level among East Asian countries. The aim of our study is to identify novel biomarkers for lung cancer risk in high radon areas using a proteomic approach. In our transitional study, a total of 81 participants of non-smokers were examined, consist of 25 lung cancer patients (LC), 16 healthy controls from low levels of natural radiation areas (LLNRA) and 40 healthy controls from high levels of natural radiation areas (HLNRA). The results showed that a total of 799 differentially expressed proteins were identified. Among these, a total of 25 proteins were observed in both LC and HLNRA, but not in LINRA. Owing to the results obtained from this study, we also point out the research direction regarding the validation of some new candidate protein as a biomarker to screen population with high risk for lung cancer in the area with high levels of radon.

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