scholarly journals Bioregulatory drugs in osteoarthritis management

2019 ◽  
pp. 76-83
Author(s):  
O. A. Shavlovskaya
Keyword(s):  
Chronic Pain ◽  
Pain Relief ◽  
Combined Treatment ◽  
Pain Syndrome ◽  
Cartilage Destruction ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Functional Improvement ◽  
Chronic Pain Syndrome ◽  
Matrix Loss

Osteoarthritis (OA) is a degenerative joint disease. Modern theories consider various structural (cartilage destruction) and biophysical disorders (matrix loss of glycosaminoglycans) as the basis of acute and chronic pain syndrome. The main aim of OA therapy is pain relief and functional improvement. To manage pain syndrome in OA it is reasonable to use complex bioregulatory drugs (CBD) (Traumeel S, Zeel T, Discus compositum) both in monotherapy and in combined treatment. The effectiveness of CBD is comparable to that of NSAIDs and CS.

scholarly journals ENSURING ACCESS TO PAIN RELIEF AS HUMAN RIGHTS

2018 ◽  
Vol 5 (1) ◽  
pp. 10-18
Author(s):  
K. Shapoval-Deinega K. ◽  
A. Rokhanskiy ◽  
O. Riga ◽  
A. Penkov
Keyword(s):  
Chronic Pain ◽  
Palliative Care ◽  
Human Rights ◽  
Pain Relief ◽  
Professional Training ◽  
Pain Syndrome ◽  
Chronic Pain Management ◽  
Chronic Pain Syndrome ◽  
Long Time

ENSURING ACCESS TO PAIN RELIEF AS HUMAN RIGHTSK. Shapoval-Deinega, A. Rokhanskiy, O. Riga, A. PenkovThe article presents the results of a selective study on the access to anesthesia. It has been determined that in most cases the goal of chronic pain management has not been achieved for a long time, the expected level of successful anesthesia has not been achieved in 80-90% of those in need, anesthesia is prescribed formally (“any prescription is a good prescription”), without taking into account clinical recommendations and clinical guidelines, that is doctors do not adhere to the principles of the WHO regarding the prescription of analgesics, approved by the Order of the Ministry of Health No. 311 as of 15 April 2012 “On the approval and implementation of medical and technological documents for standardization of palliative care in chronic pain syndrome”. The authors believe that professional training of doctors requires changes regarding the quality of palliative care in accordance with WHO standards, wide implementation of modern scientific concepts of anesthesia in all areas of medical staff training.Key words: palliative care, anesthesia, human rights. ЗАБЕЗПЕЧЕННЯ ДОСТУПУ ДО ЗНЕБОЛЕННЯ ЯК ПРАВА ЛЮДИНИК. Шаповал-Дейнега, А. Роханський, О. Ріга, А. Пеньков У статті наведено результати вибіркового дослідження щодо забезпечення людини до знеболення. Визначено, що у більшості випадків не досягнута мета лікування хронічного больового синдрому протягом тривалого часу, не досягнуто очікуваного рівня успішного знеболення у 80–90 % осіб, що цього потребують, знеболення призначається формально («щось призначили – і гаразд»), без урахування клінічних рекомендацій та клінічних настанов, тобто лікарі не дотримуються принципів ВООЗ щодо призначення знеболюючих засобів, які містяться у наказі МОЗ № 311від 25.04.2012 "Про затвердження та впровадження медико-технологічних документів зі стандартизації паліативної медичної допомоги при хронічному больовому синдромі". Автори вважають, що ротребує змін фахова підготовка лікарів щодо якості надання паліативної допомоги відповідно до стандартів ВООЗ, широкої імплементації сучасних наукових уявлень про знеболення в усі ланки підготовки медичних працівників.Ключові слова: паліативна допомога, знеболення, права людини. ОБЕСПЕЧЕНИЕ ДОСТУПА К ОБЕЗБОЛИВАНИЮ КАК ПРАВО ЧЕЛОВЕКАК. Шаповал-Дейнега, А. Роханский, О. Рига, А. ПеньковВ статье приведены результаты выборочного исследования по обеспечению человека к обезболиванию. Определено, что в большинстве случаев не достигнута цель лечения хронического болевого синдрома в течение длительного времени, не достигнуто ожидаемого уровня успешного обезболивания в 80-90% лиц, нуждающихся, обезболивания назначается формально ( «что-то назначили - и ладно»), без учета клинических рекомендаций и клинических руководств, то есть врачи не соблюдают принципы ВОЗ по назначению обезболивающих средств, которые содержатся в приказе Минздрава № 311вид 25.04.2012 "Об утверждении и внедрении медико-технологических документов по стандартизации паллиативной медицинской помощи при хроническом болевом синдроме ". Авторы считают, что ротребуе изменений профессиональная подготовка врачей по качеству оказания паллиативной помощи в соответствии со стандартами ВОЗ, широкой имплементации современных научных представлений о обезболивания во все звенья подготовки медицинских работников.Ключевые слова: паллиативная помощь, обезболивание, права человека.

CHRONIC PAIN SYNDROME IN PEDIATRIC ONCOLOGICAL PALLIATIVE PATIENTS IN RUSSIA

2019 ◽  
Vol 98 (1) ◽  
pp. 115-121
Author(s):  
A.V. Pshonkin ◽  
◽  
I.V. Serkova ◽  
N.V. Myakova ◽  
N.N. Kotskaya ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Pain Syndrome ◽  
Chronic Pain Syndrome ◽  
Palliative Patients

Alexithymia and hypnotisability in the chronic pain syndrome

Pain ◽  
1990 ◽  
Vol 41 ◽  
pp. S333 ◽  
Author(s):  
F.R. James ◽  
R.G. Large
Keyword(s):  
Chronic Pain ◽  
Pain Syndrome ◽  
Chronic Pain Syndrome

The phenomenon of migration of nociogenic structures in the human sensor-algic system (results of clinical and neurophysiological studies and morphological experiments)

2020 ◽  
pp. 16-24
Author(s):  
Maksim Vladimirovich Shpagin ◽  
Mikhail Valerievich Kolesnikov ◽  
Olga Yurievna Khutorskaya ◽  
Dmitriy Evgenievich Timoshkin ◽  
Artem Andreevich Belikin ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Nervous System ◽  
Pain Syndrome ◽  
Point Of View ◽  
Chronic Pain Syndrome ◽  
Integrative Therapy ◽  
Neurophysiological Studies ◽  
Positive Results ◽  
Structural Point ◽  
Chronicity Of Pain

From the informational and structural point of view, the chronicity of pain is associated with the migration of nociogenic zones. The phenomenon of migration is based on the mechanisms of neuroplasticity, compensatory-restorative processes in the nervous system. On the basis of the phenomenon of migration of the nociogenic zone, a system of regional integrative therapy of chronic pain syndrome has been developed. Recommendations on the advisability of invasive shutdown of the nociogenic zone using invasive pharmacotherapy or surgical denervation have been proposed. In the course of studying the characteristics of chronic pain, depending on the duration of the disease, a direct proportional correlation was revealed between the increase in the components of pain and the duration of the pain syndrome, which can be explained by the increase in the number of nociogenic structures that form the complexity and stability of the pain syndrome. Thus, the necessity of neurodestructive interventions increases for attaining positive results. An important area of therapy is the inclusion of psychotherapy, pharmacotherapy and neuromodulation into the system of regional-integrative influence.

scholarly journals Relationship between catechol-o-methyltransferase gene polymorphism and pain syndrome in breast cancer patients

2020 ◽  
Vol 14 (2) ◽  
pp. 72-85
Author(s):  
Arina P. Spasova ◽  
I. V. Kurbatova ◽  
O. Y. Barysheva ◽  
G. P. Tikhova
Keyword(s):  
Breast Cancer ◽  
Chronic Pain ◽  
Postoperative Period ◽  
Mutant Allele ◽  
Pain Syndrome ◽  
Comt Gene ◽  
Nucleotide Polymorphisms ◽  
Chronic Pain Syndrome ◽  
Narcotic Analgesics ◽  
Single Nucleotide

The goal of the study was to explore the influence of single-nucleotide polymorphisms of the COMT gene on the formation and features of pain syndrome, the level of anxiety, and the need for narcotic analgesics in patients with breast cancer. Materials and methods. The intensity of pain and opioid consumption in the postoperative period were evaluated in 58 patients who met the inclusion criteria of the study and were operated for breast cancer. The frequency of chronic pain syndrome after mastectomy was studied in the same group of patients after a year by using short pain questionnaires, McGill Pain Questionnaire and PainDetect. The anxiety level was assessed by using the HADS questionnaire. Genotyping was performed for single-nucleotide polymorphisms, rs4680, rs740603, rs2097603 = rs2070577, rs4633, of the COMT gene localized in the 22q11.21 region in the studied group of patients. The relationship between the carrier of different genotypes and the intensity of acute and chronic pain, the severity of the pain rating index for sensory and affective characteristics, the presence of a neuropathic component of pain, and the severity of anxiety were studied in the entire sample. The use of narcotic analgesics was evaluated in the postoperative period (IU/day and IU/course) and for the relief of chronic pain. Results. It is shown that the intensity of postoperative pain and the severity of anxiety do not depend on the presence of a mutant allele for the studied polymorphisms of the COMT gene, while the postoperative consumption of opioids in patients with the rs4680 missense mutation in the exon of this gene is significantly less. The dependence of the intensity of chronic pain syndrome and the severity of anxiety on the presence of a mutant allele for the polymorphic locus rs4680 localized in the exon of the COMT gene was established. No significant relationship was observed between the mutant alleles and the use of opioids for chronic pain relief after mastectomy. Conclusion. Genotyping for the COMT gene polymorphisms can be useful for choosing the optimal tactics of pain management in patients with breast cancer.

Sign in / Sign up

Export Citation Format

Share Document