scholarly journals On the mechanisms of the synergistic action of tolperisone, meloxicam and B vitamins in the treatment of peripheral pain syndromes

2020 ◽  
pp. 54-64
Author(s):  
O. A. Gromova ◽  
I. Yu. Torshin ◽  
M. V. Putilina ◽  
L. A. Maiorova ◽  
V. A. Semenov
Keyword(s):  
Molecular Mechanisms ◽  
Muscle Relaxants ◽  
B Vitamins ◽  
Neuroprotective Effects ◽  
Pain Syndromes ◽  
Peripheral Pain ◽  
Anti Inflammatory ◽  
Group B ◽  
Leukotriene A4 ◽  
Group B Vitamins

Introduction: The combined use of non-steroidal anti-inflammatory drugs (NSAIDs), muscle relaxants and group B vitamins is a promising direction for combined pharmacotherapy of peripheral pain syndromes.Purpose: to analyze the molecular mechanisms of the synergism of the muscle relaxant tolperisone, a non-steroidal anti-inflammatory drug meloxicam and vitamins B1, B6 and B12 as part of complex pharmacotherapy of pain.Materials and methods: differential chemoreactome analysis of NSAID molecules and muscle relaxants, proteomic analysis of the effects of B vitamins.Results: Synergistic interactions are maintained by (1) inhibiting cyclooxygenase-2 and leukotriene A4 hydrolases; (2) inhibition of the effects of IL-1β, TNFα, NF-kB, TLR4, RANKL, matrix metalloproteinases; (3) antioxidant effect (increased expression of superoxide dismutase-1 and glutathione peroxidase). Group B vitamins enhance the effects of tolperisone and meloxicam due to the manifestation of independent anti-inflammatory (neutralization of homocysteine, decreased expression of pro-inflammatory cytokines TNFα, IL-1b and factor NF-kB activity), analgesic (modulation of opioidergic pathways) and neuroprotective effects (support of amino acid expression, metabolism and neuro lipids, ATP synthesis and remyelination).Conclusions: The triple scheme “tolperisone + meloxicam + vitamins B1 / B6 / B12” is characterized by a number of undeniable advantages: (1) lack of dependence, (2) anti-inflammatory effect, (3) neuroprotective and remyelinating effects, (4) elimination of muscle hypertonicity. Such combination therapy can be used in patients of various age groups with comorbid conditions (diabetes mellitus, arterial hypertension, cerebrovascular diseases, gastrointestinal diseases) and does not require an increase in NSAIDs and significantly reduces the risk of side effects.

scholarly journals Efficacy of pollen extract in association with group B vitamins for pain relief in chronic prostatitis/chronic pelvic pain syndrome: A survey of urologists' knowledge about its clinical application

2017 ◽  
Vol 89 (1) ◽  
pp. 22 ◽  
Author(s):  
Giacomo Maria Pirola ◽  
Stefano Puliatti ◽  
Tommaso Bocchialini ◽  
Eugenio Martorana ◽  
Salvatore Micali ◽  
...  
Keyword(s):  
Chronic Prostatitis ◽  
Chronic Pelvic Pain ◽  
Chronic Pelvic Pain Syndrome ◽  
Pain Syndrome ◽  
B Vitamins ◽  
Pelvic Pain Syndrome ◽  
Plant Product ◽  
Group B ◽  
Group B Vitamins

Introduction and aim of the study: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPSS) is a pathology of high prevalence in Italian male population, difficult to diagnose and to treat and with poor response to conventional therapy. Aim of this study was to review the evidence of the literature about the therapeutic effects of a plant product containing flower pollen extracts and group B vitamins on symptoms resolution and amelioration of CP/CPPS patients’ quality of life and to investigate the knowledge among practicing urologists about the clinical application of this product. Materials and methods: A group of 38 urologists was submitted to an investigational survey of the knowledge of the clinical applications of a plant product containing flower pollen extracts and group B vitamins Results: 71% of the urologists interviewed prescribed the plant product for CBP and CP/CPPS at least one time in a month and 11% prescribed it more than 5 times; 67% had evidence of clear ameliorations in pain relief and on patient's quality of life and 47% reported that the effectiveness is comparable to NSAIDs; 39% also reported a significant effect for the improvement of the urinary symptoms of patients. No gastric or general side effects have been noticed during the administration period of this plant product. Finally, the cost of the product has always reported to be sustainable for the patients. Conclusions: From the results of this investigational survey, we can state that the plant product containing flower pollen extracts and group B vitamins is well-known and demonstrated beneficial effects on symptoms resolution and amelioration of quality of life in patients with chronic prostatitis/chronic pelvic pain syndrome.

Changes in management of patients with diseases of musculoskeletal system and joints

2021 ◽  
pp. 36-40
Author(s):  
A. L. Vertkin ◽  
A. N. Barinov ◽  
G. Yu. Knorring
Keyword(s):  
Side Effects ◽  
Pain Relief ◽  
Severe Pain ◽  
Pain Syndrome ◽  
Cooperative Action ◽  
Pain Syndromes ◽  
Adequate Pain Relief ◽  
Inflammatory Drugs ◽  
Group B ◽  
Group B Vitamins

Pain syndrome accompanies the vast majority of diseases; therefore, the issues of adequate pain relief remain topical not only for urgent conditions, but also for everyday medical practice. Modern and changed in recent years approaches to the appointment of anesthetic therapy should take into account not only the pathogenetic mechanisms of the development of pain syndrome in a particular patient, but also the need to use drug combinations. This allows for the potentiation of the analgesic effect, reduction of effective dosages of individual drugs and minimization of side effects. In case of severe pain syndrome in the presence of signs of impaired nociception, neuropathic and muscle-fascial pain syndromes, the use of non-steroidal anti-inflammatory drugs in conjunction with group B vitamins is justified. The article considers the pathogenetic details of such a combination therapy, reveals the mechanisms of the cooperative action of the proposed combination of drugs.

Electrochemical methods for determining group B vitamins

2013 ◽  
Vol 68 (7) ◽  
pp. 565-576 ◽  
Author(s):  
I. P. Antal ◽  
Ya. R. Bazel ◽  
Zh. A. Kormosh
Keyword(s):  
B Vitamins ◽  
Electrochemical Methods ◽  
Group B ◽  
Group B Vitamins

Progress in Determination of Group B Vitamins

1988 ◽  
Vol 71 (2) ◽  
pp. 446-446
Author(s):  
M Bourgeay-Causse ◽  
M Guillaumon ◽  
M Leclercq
Keyword(s):  
B Vitamins ◽  
Group B ◽  
Group B Vitamins

scholarly journals Efficiency of topical application of regenerants and reparents containing group B vitamins in patients with post-burn symblepharon

2021 ◽  
Vol 21 (4) ◽  
pp. 253-257
Author(s):  
M.B. Gushсhina ◽  
◽  
D.S. Afanasyeva ◽  
◽  
◽  
...  
Keyword(s):  
Dry Eye ◽  
Topical Application ◽  
Pantothenic Acid ◽  
Tear Film ◽  
B Vitamins ◽  
Artificial Tears ◽  
Tear Production ◽  
Group B ◽  
Group B Vitamins ◽  
Ocular Burns

Ocular burns can lead to complex anatomic disorders and dysfunctions of the ocular surface, as well as palpebral conjunctiva and fornixes, resulting in permanent decrease in basal tear production in long-term period. Some patients need surgery to treat symblepharon and restore eyelids position, conjunctival fornixes and corneal transparency. Nonetheless, as a rule, it is impossible to resolve symptoms of dry eye due to loss of tear-producing elements. Severe decrease of tear production causes significant discomfort for such patients and enforce keratopathy even in good cosmetic result after surgery. To provide the most optimal results on the all steps of the rehabilitation for the patients with ocular burns, it is worth to add cornea reparants and artificial tears containing group B vitamins. On the basis of a clinical case was showed efficiency of topical application of regenerants and reparents containing group B vitamins in patients with post-burn symblepharon. A cornea epithelization was enhanced and improved tear film stability (tear break-up time changed from 1 to 3 seconds). Moreover, such treatment also resulted in discomfort correction and better visual acuity (change from 0.1 to 0.4). Keywords: ocular burn, artificial tears, lubricants, dexpanthenol, pantothenic acid, B5, cyanocobalamin, B12, keratopathy, dry eye syndrome. For citation: Gushсhina M.B., Afanasyeva D.S. Efficiency of topical application of regenerants and reparents containing group B vitamins in patients with post-burn symblepharon. Russian Journal of Clinical Ophthalmology. 2021;21(4):253–257 (in Russ.). DOI: 10.32364/2311-7729- 2021-21-4-253-257.

Group B vitamins protect murine cerebellar granule cells from glutamate/NMDA toxicity

Neuroreport ◽  
2004 ◽  
Vol 15 (14) ◽  
pp. 2241-2244 ◽  
Author(s):  
Yanpeng Lin ◽  
Angele Desbois ◽  
Susan Jiang ◽  
Sheng T. Hou
Keyword(s):  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
B Vitamins ◽  
Cerebellar Granule ◽  
Group B ◽  
Group B Vitamins

Photo-physical and interactional behavior of two members of group B vitamins in different solvent media

2017 ◽  
Vol 1144 ◽  
pp. 265-272 ◽  
Author(s):  
M.S. Zakerhamidi ◽  
L. Zare Haghighi ◽  
S.M. Seyed Ahmadian
Keyword(s):  
B Vitamins ◽  
Group B ◽  
Group B Vitamins
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