scholarly journals Use of topical reparative creams for sensitive and atopic skin in children

2021 ◽  
pp. 205-210
Author(s):  
T. V. Kovalevskaya-Kucheryavenko
Keyword(s):  
Atopic Dermatitis ◽  
Antifungal Agents ◽  
Pediatric Population ◽  
Adherence To Treatment ◽  
Sensitive Skin ◽  
Rapid Reduction ◽  
Common Skin ◽  
Atopic Skin ◽  
History Of ◽  
Anti Inflammatory

In recent decades, there has been a significant increase in allergy pathology among the pediatric population. One in five children at a pediatrician’s consultation has an allergic disease or has a history of allergy, or manifestations of an atopic constitution. Also, in recent years, the term «sensitive skin» has become increasingly common in the medical literature. It is an independent syndrome that manifests itself in two forms: objective, in which the syndrome clinic is observed in parallel with the skin disease, and subjective when the manifestations of the syndrome occur in healthy skin. The main manifestations of sensitive skin syndrome are burning, itching, and tingling sensations, as well as thickening and dryness of the skin in response to environmental factors. Often, sensitive skin is associated with the most common skin pathology of childhood - atopic dermatitis. This association obliges the use of combined external therapy in practice. Topical glucocorticosteroids in the form of monotherapy or combination with antibacterial and/or antifungal agents are designed to control the dynamics of inflammation and lead to the achievement and prolongation of remission. However, the combination of anti-inflammatory agents with reparative creams is more effective because it enhances the healing processes of the damaged skin.The article describes clinical cases of skin treatment in children with a history of allergies, atopic dermatitis, and sensitive skin syndrome. The therapy used restorative agents of dermocosmetics in the example of reparative cream. Clinical examples showed high efficacy of the combination of topical anti-inflammatory agents and reparative cream. This combination led to a more rapid reduction of dryness and itching, the intensity of inflammation, contributed to the rapid recovery of damaged skin, increased adherence to treatment by patients and patient’s parents.

scholarly journals Modern approaches to external therapy of sensitive skin area in atopic dermatitis in children: focus on topical calcineurin inhibitors

2019 ◽  
pp. 156-167
Author(s):  
E. N. Saverskaya
Keyword(s):  
Atopic Dermatitis ◽  
Pediatric Population ◽  
Clinical Manifestations ◽  
Local Therapy ◽  
Calcineurin Inhibitors ◽  
Skin Barrier ◽  
The Body ◽  
Skin Area ◽  
Sensitive Skin ◽  
Topical Calcineurin Inhibitors

Due to high prevalence in the pediatric population, chronic recurrent course and difficulties in choosing the local therapy, atopic dermatitis is an urgent problem for pediatricians, dermatologists and allergists. The review presents data on the prevalence and features of the clinical manifestations of atopic dermatitis in various age periods. The authors consider structural, functional and immunological features of the skin barrier are considered in detail under normal and under pathological conditions. They emphasize the problems of quality of life, compliance and steroidophobia of patients with atopic dermatitis. Particular attention is paid to the concept of sensitive skin, the definition of this concept and the localization of sensitive skin area on the surface of the body. The article describes approaches to the method of choosing external therapy according to the European guidelines for the treatment of atopic dermatitis in 2018. It presents a modern practical algorithm for prescribing local anti-inflammatory drugs (topical glucocorticosteroids, topical calcineurin inhibitors) taking into account the severity of the clinical manifestations of the disease and the areas of application (sensitive skin areas/other parts of the body). The authors provide evidence of the efficacy and safety of topical calcineurin inhibitors, in particular pimecrolimus, in the treatment of patients with mild to moderate severity of atopic dermatitis, especially in sensitive skin areas.

scholarly journals Increased lipoxin B4 levels in children with atopic dermatitis

2019 ◽  
Vol 59 (5) ◽  
pp. 271-5
Author(s):  
Himmet Haluk Akar ◽  
Mikdat Yildiz
Keyword(s):  
Atopic Dermatitis ◽  
Skin Prick Test ◽  
Inflammatory Mediator ◽  
Immunoglobulin E ◽  
Pediatric Population ◽  
Control Group ◽  
Prick Test ◽  
Significant Difference ◽  
Anti Inflammatory ◽  
And Control

Background Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in the pediatric population. The pathophysiology of AD is complex and not clearly understood. The role of lipoxin B4 (LXB4), an anti-inflammatory mediator, has not been sufficiently investigated in children with AD to our knowledge. Objective To compare the levels of serum LXB4 between children with AD and healthy controls.   Methods Three groups of children were enrolled in this study: a SPT-Pos group (skin prick test positive 21 subjects with AD), a SPT-Neg group (skin prick test negative 22 subjects with AD), and a control group (23 healthy subjects). Subjects’ serum LXB4 levels of were measured with an ELISA technique. Also, eosinophil counts and total immunoglobulin E (IgE) levels were compared among all groups. Results We observed significantly higher LXB4 levels in AD patients than in controls. Also, LXB4 levels were significantly higher in the SPT-Pos group than in the SPT-Neg group and control group. However, no significant difference was observed between the SPT-Neg and control groups. Conclusion The LXB4 may have an anti-inflammatory mediator role in the pathogenesis of AD in children. The LXB4-associated pathways may be considered in the development of novel therapeutic approaches for the treatment of patients with AD.

Eczematous Eruptions in Childhood

1981 ◽  
Vol 3 (1) ◽  
pp. 23-30
Author(s):  
Sidney Hurwitz
Keyword(s):  
Atopic Dermatitis ◽  
Seborrheic Dermatitis ◽  
General Term ◽  
Generic Term ◽  
Serous Discharge ◽  
Childhood Population ◽  
Common Skin ◽  
History Of ◽  
Symptom Complex ◽  
Physiologic Responses

Atopic dermatitis, one of the most common skin disorders seen in infants and children, is frequently a source of frustration to parents and presents a challenge to immunologists, pediatricians, and dermatologists alike. Affecting approximately 3% of the childhood population, atopic dermatitis frequently causes confusion because the terms eczema and dermatitis are often used synonymously and interchangeably.1 Eczema is a generic term that identifies an acute inflammatory cutaneous eruption characterized by itching, redness, papules, vesicles, edema, serous discharge, and crusting (Fig 1). Dermatitis without a qualifying adjective is less definitive and merely refers to an inflammation of the skin which may result in a spectrum of lesions varying from acute necrosis and ulceration to simple erythema.2 A modifying adjective therefore is frequently added to the general term in an effort to identify the specific eruption under consideration, hence the terms contact dermatitis, seborrheic dermatitis, nummular dermatitis, and atopic dermatitis. PATHOGENESIS Atopic dermatitis is the most common cause of eczema in children. Although its cause remains unknown, the disorder represents an eczematous disorder of characteristic distribution, a hereditary symptom complex in individuals with paradoxical physiologic responses to pharmacologic stimuli, a constitutional predisposition to develop dry skin and pruritus, and a personal or family history of allergy.

Intraorbital Abscess: A Rare Cause of Orbit Compression

FACE ◽  
2021 ◽  
pp. 273250162110050
Author(s):  
Samuel Ruiz ◽  
Rizal Lim
Keyword(s):  
Pediatric Population ◽  
Rare Complication ◽  
Disease Process ◽  
Rare Condition ◽  
External Drainage ◽  
Direct Extension ◽  
Life Threatening ◽  
History Of ◽  
High Index Of Suspicion ◽  
Prompt Diagnosis

Introduction: Intraorbital abscess is a rare complication of rhinosinusitis that affects most commonly the pediatric population. It is thought to be caused by direct extension or venous spread of infections from contiguous sites and can lead to life-threatening complications, like permanent visual loss and cerebral abscesses. Objectives: Intraorbital abscess is a rare condition that requires prompt diagnosis and treatment to avoid serious complications. Our objectives are to provide an overview of this rare disease process and its management including our successful treatment experience. Case Description: We present a 2 case report of a 13-year-old pediatric male and a 66-year-old male with history of chronic sinusitis who presented with a right intraorbital abscess successfully treated with external drainage with decompression of the orbit. Conclusion: When intraorbital abscess is encountered, a high index of suspicion is needed to allow prompt and accurate diagnosis for this infrequent condition. Timely surgical drainage of the abscess is needed to prevent the development of fatal complications.

scholarly journals Anti-inflammatory effects of Capparis ecuadorica extract in phthalic-anhydride-induced atopic dermatitis of IL-4/Luc/CNS-1 transgenic mice

2020 ◽  
Vol 58 (1) ◽  
pp. 1263-1276
Author(s):  
Bo Ram Song ◽  
Su Jin Lee ◽  
Ji Eun Kim ◽  
Hyeon Jun Choi ◽  
Su Ji Bae ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Transgenic Mice ◽  
Phthalic Anhydride ◽  
Anti Inflammatory
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