Role of Ultrasonoraphy in Gall bladder Dyskinsia as a cause of Functional Dyspepsia Symptoms

Abstract Background Although gall bladder perforation (GBP) is not common, it is considered a life-threating condition, and the possibility of occurrence in cases of acute cholecystitis must be considered. The aim of this study was to assess the role of multi-slice computed tomography (MSCT) in the assessment of GBP. Results It is a retrospective study including 19 patients that had GBP out of 147, there were 11 females (57.8%) and 8 males (42.1%), aged 42 to 79 year (mean age 60) presented with acute abdomen or acute cholecystitis. All patients were examined with abdominal ultrasonography and contrast-enhanced abdominal MSCT after written informed consent was obtained from the patients. This study was between January and December 2018. Patients with contraindications to contrast-enhanced computed tomography (CT) (pregnancy, acute kidney failure, or allergy to iodinated contrast agents) who underwent US only were excluded. Patients with other diagnoses, such as acute diverticulitis of the right-sided colon or acute appendicitis, were excluded. The radiological findings were evaluated such as GB distention; stones; wall thickening, enhancement, and defect; pericholecystic free fluid or collection; enhancement of liver parenchyma; and air in the wall or lumen. All CT findings are compared with the surgical results. Our results revealed that the most important and diagnostic MSCT finding in GBP is a mural defect. Nineteen patients were proved surgically to have GBP. Conclusion GBP is a rare but very serious condition and should be diagnosed and treated as soon as possible to decrease morbidity and mortality. The most accurate diagnostic tool is the CT, MSCT findings most specific and sensitive for the detection of GBP and its complications.

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Late Port Site Metastasis from Occult Gall Bladder Carcinoma After Laparoscopic Cholecystectomy for Cholelithiasis: The Role of 18F-FDG PET/CT

Nuclear Medicine and Molecular Imaging ◽

10.1007/s13139-014-0294-0 ◽

2014 ◽

Vol 48 (4) ◽

pp. 317-320 ◽

Cited By ~ 3

Author(s):

Punit Sharma ◽

Piyali Chatterjee

Keyword(s):

Laparoscopic Cholecystectomy ◽

Gall Bladder ◽

Bladder Carcinoma ◽

Fdg Pet ◽

Port Site Metastasis ◽

Gall Bladder Carcinoma ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Role of Combination Chemotherapy with 5-Fluorouracil, Cisplatin and Paclitaxel for Advanced Gall Bladder Cancer

Journal of Cancer Therapy ◽

10.4236/jct.2014.53032 ◽

2014 ◽

Vol 05 (03) ◽

pp. 246-252 ◽

Cited By ~ 1

Author(s):

Mumtaz Ahmad Ansari ◽

Satyendra K. Tiwary ◽

Uday Pratap Shahi ◽

Vijay K. Shukla

Keyword(s):

Bladder Cancer ◽

Gall Bladder ◽

Combination Chemotherapy ◽

Gall Bladder Cancer ◽

Advanced Gall Bladder Cancer

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Role of Hepatobiliary Scintigraphy and Ultrasonography in the Diagnosis of Biliary Atresia in Infant with Neonatal Jaundice – Experiences in NINMAS

Bangladesh Journal of Nuclear Medicine ◽

10.3329/bjnm.v18i1.34935 ◽

2017 ◽

Vol 18 (1) ◽

pp. 51-53

Author(s):

Nasreen Sultana ◽

Zeenat Jabin ◽

Md Bashir ◽

Rahima Parveen ◽

Shamim MF Begum ◽

...

Keyword(s):

Retrospective Study ◽

Gall Bladder ◽

Biliary Atresia ◽

False Positive ◽

Hepatic Dysfunction ◽

Hepatobiliary Scintigraphy ◽

Hida Scan ◽

Complementary Role

Objective: The purpose of this study was to determine whether gall bladder visualization can help to exclude the biliary atresia in hepatobiliary scintigraphic studies of infants with persistent jaundice.Methods: This is a retrospective study carried out at the National Institute of Nuclear Medicine and Allied Sciences (NINMAS). Study subjects include infants with neo-natal jaundice who underwent Hepatobiliary scintigraphies for suspected biliary atresia and study period was 2 years. Food was withheld for 4 hours before the examination. Anterior images of liver and gall bladder were taken after i/v administration of 2 -3 mci 99m Tc labeled Brida (HIDA) at 5 min interval for 2 hours then at 4 hours and 24 hours. Non-visualization of bowel activity in HIDA scan in 24hours delayed images was considered as cases of diagnosis of biliary atresia.Results: Thirty-six patients were included in this retrospective study. Patent biliary channels was seen by scintigraphies in 17(47%) patients and biliary atresia was seen in 19(52%) patients. By abdominal US non- visualization of gall bladder were found in 25(69%) cases and gall bladder visualized in 11(30%) cases. Eight (22%) of 36 patients had biopsy confirmed biliary atresia; all of these had positive scintigraphies and (60%) had positive sonographic findings. Among the 5 false-positive scintigraphies caused by hepatic dysfunction and 2 had normal sonography. Thirty-six patients had periscintigraphic sonography. There were 25/36 (61%) abnormal studies, which included cases with small gallbladder (n = 8) and non-visualized gallbladder (n = 17), but not periportal fibrosis.Conclusion: Gall bladder was usually visible on Hepatobiliary scintigraphy of fasting patients with biliary patency. Both hepatobiliary scintigraphy and sonography are currently the standard imaging investigations for suspected biliary atresia. The complementary role, in which scintigraphy and sonography are important, and recommend follow-up imaging reassessment before making definitive surgical decisions. This will serve to decrease the frequency of false-positive imaging diagnoses of biliary atresia, and hence, avoid unnecessary surgeries.Bangladesh J. Nuclear Med. 18(1): 51-53, January 2015

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The role of H. pylori infection in gall bladder cancer: clinicopathological study

Tumor Biology ◽

10.1007/s13277-015-3444-9 ◽

2015 ◽

Vol 36 (9) ◽

pp. 7093-7098 ◽

Cited By ~ 10

Author(s):

Ehsan Hassan Hassan ◽

Shawkat S. Gerges ◽

Kamal A. El-Atrebi ◽

Hala T. El-Bassyouni

Keyword(s):

Bladder Cancer ◽

Gall Bladder ◽

Gall Bladder Cancer ◽

Clinicopathological Study ◽

H Pylori

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Duodenal Dysbiosis and Relation to the Efficacy of Proton Pump Inhibitors in Functional Dyspepsia

International Journal of Molecular Sciences ◽

10.3390/ijms222413609 ◽

2021 ◽

Vol 22 (24) ◽

pp. 13609

Author(s):

Lucas Wauters ◽

Raúl Y. Tito ◽

Matthias Ceulemans ◽

Maarten Lambaerts ◽

Alison Accarie ◽

...

Keyword(s):

Functional Dyspepsia ◽

Proton Pump Inhibitors ◽

Proton Pump ◽

Potential Role ◽

Short Term ◽

Beneficial Effects ◽

Rrna Sequencing ◽

Before And After

Proton pump inhibitors (PPI) may improve symptoms in functional dyspepsia (FD) through duodenal eosinophil-reducing effects. However, the contribution of the microbiome to FD symptoms and its interaction with PPI remains elusive. Aseptic duodenal brushings and biopsies were performed before and after PPI intake (4 weeks Pantoprazole 40 mg daily, FD-starters and controls) or withdrawal (2 months, FD-stoppers) for 16S-rRNA sequencing. Between- and within-group changes in genera or diversity and associations with symptoms or duodenal factors were analyzed. In total, 30 controls, 28 FD-starters and 19 FD-stoppers were followed. Mucus-associated Porphyromonas was lower in FD-starters vs. controls and correlated with symptoms in FD and duodenal eosinophils in both groups, while Streptococcus correlated with eosinophils in controls. Although clinical and eosinophil-reducing effects of PPI therapy were unrelated to microbiota changes in FD-starters, increased Streptococcus was associated with duodenal PPI effects in controls and remained higher despite withdrawal of long-term PPI therapy in FD-stoppers. Thus, duodenal microbiome analysis demonstrated differential mucus-associated genera, with a potential role of Porphyromonas in FD pathophysiology. While beneficial effects of short-term PPI therapy were not associated with microbial changes in FD-starters, increased Streptococcus and its association with PPIeffects in controls suggest a role for duodenal dysbiosis after long-term PPI therapy.

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