scholarly journals Duodenal Dysbiosis and Relation to the Efficacy of Proton Pump Inhibitors in Functional Dyspepsia

2021 ◽  
Vol 22 (24) ◽  
pp. 13609
Author(s):  
Lucas Wauters ◽  
Raúl Y. Tito ◽  
Matthias Ceulemans ◽  
Maarten Lambaerts ◽  
Alison Accarie ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Potential Role ◽  
Short Term ◽  
Beneficial Effects ◽  
Rrna Sequencing ◽  
Before And After

Proton pump inhibitors (PPI) may improve symptoms in functional dyspepsia (FD) through duodenal eosinophil-reducing effects. However, the contribution of the microbiome to FD symptoms and its interaction with PPI remains elusive. Aseptic duodenal brushings and biopsies were performed before and after PPI intake (4 weeks Pantoprazole 40 mg daily, FD-starters and controls) or withdrawal (2 months, FD-stoppers) for 16S-rRNA sequencing. Between- and within-group changes in genera or diversity and associations with symptoms or duodenal factors were analyzed. In total, 30 controls, 28 FD-starters and 19 FD-stoppers were followed. Mucus-associated Porphyromonas was lower in FD-starters vs. controls and correlated with symptoms in FD and duodenal eosinophils in both groups, while Streptococcus correlated with eosinophils in controls. Although clinical and eosinophil-reducing effects of PPI therapy were unrelated to microbiota changes in FD-starters, increased Streptococcus was associated with duodenal PPI effects in controls and remained higher despite withdrawal of long-term PPI therapy in FD-stoppers. Thus, duodenal microbiome analysis demonstrated differential mucus-associated genera, with a potential role of Porphyromonas in FD pathophysiology. While beneficial effects of short-term PPI therapy were not associated with microbial changes in FD-starters, increased Streptococcus and its association with PPIeffects in controls suggest a role for duodenal dysbiosis after long-term PPI therapy.

scholarly journals Do food bioactives play a role in attention-deficit/ hyperactivity disorder?

2018 ◽  
Vol 4 ◽  
Author(s):  
Klaus W. Lange
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Potential Role ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Short Term ◽  
Hyperactivity Disorder ◽  
Common Diagnosis

Attention-deficit/hyperactivity disorder (ADHD) is a common diagnosis in children, which may persist into adulthood. Short-term benefits of pharmacological treatment have been shown, but concerns regarding long-term efficacy and safety have led to a search for alternative treatments. Nutrition may be an important factor in psychiatric disorders. At group level, food bioactives do not appear to play a significant pathogenetic or therapeutic role in ADHD. Benefits of treatment with omega-3 fatty acids, vitamins and minerals may be confined to individuals deficient in these micronutrients. Dietary patterns may be of greater importance than individual nutrients. However, both diet and consumption of certain nutrients may be precursors or consequences of ADHD. The controversy surrounding the clinical and pathogenetic heterogeneity of ADHD complicates the assessment of food bioactives. The identification of a potential role of food bioactives in ADHD is hindered by the ill-defined nature of the disorder and the lack of biological markers underpinning its validity. The therapeutic efficacy of food bioactives cannot be tested by evaluating their effect on the pathophysiology of ADHD but only by observing their effects on symptom severity.

scholarly journals Role of Guanylate kinase 1 in SARS CoV-2 Replication and tumorigenesis: Potential Role for Amantadine and Novel Therapeutics in COVID-19 and Cancer Management.

2021 ◽  
Author(s):  
Mina Kelleni
Keyword(s):  
Crucial Role ◽  
Potential Role ◽  
Swot Analysis ◽  
Physiological Function ◽  
Potential Interaction ◽  
Short Term ◽  
Guanylate Kinase ◽  
Cancer Management

A recent study has suggested that guanylate kinase 1 (GK1) plays a crucial role in SARS CoV-2 replication and recommended to test GK 1 inhibitors for invitro experiments and previous studies have suggested a role in the pathogenesis of some neoplasms. We are providing a concise strengths, weaknesses, opportunities, and threats (SWOT) analysis of this hypothesis while discussing guanylate kinase physiological function, pharmacological importance. Importantly, we suggest assessing another potential interaction between SARS CoV-2 and the non-authentic membrane-associated guanylate kinases as we suggest this might add to consider the potential role of amantadine in COVID-19 management. Moreover, though GK1 role in SARS CoV-2 replication might prove valid, the available experimental inhibitors of GK 1 might not, at least for the short term, be safely used to manage COVID-19. Finally, we recommend conducting genetic, physiological, and immunological studies to explore the long-term potentials of GK-1 inhibitors suggesting they might eventually lead to a novel COVID-19 and cancer pharmacotherapeutics.

scholarly journals Adverse Effects of Proton Pump Inhibitors on Platelet Count: A Case Report and Review of the Literature

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Subhajit Mukherjee ◽  
Tanima Jana ◽  
Jen-Jung Pan
Keyword(s):  
Case Report ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Case Reports ◽  
Strong Association ◽  
Acute Interstitial Nephritis ◽  
Ulcer Disease ◽  
New Onset

Proton pump inhibitors (PPIs) are the most effective and preferred class of drugs used to treat peptic ulcer disease, gastroesophageal reflux disease, and other diseases associated with increased production of gastric acid. PPIs in general have an excellent long-term safety profile and are well-tolerated. However, studies have shown some adverse reactions (e.g., osteoporosis, Clostridium difficile-associated diarrhea, Vitamin B12 and iron deficiency, and acute interstitial nephritis) on long-term PPI use. Thrombocytopenia attributed to use of PPIs has been described in a few case reports and a retrospective study. In this case report, we describe a case of PPI-induced thrombocytopenia. In our patient, thrombocytopenia immediately developed after the initiation of PPI on two separate occasions and resolved after its discontinuation. The strong association found in our case implies the potential role of PPI in causing this rare but serious adverse reaction. Based on this case report and the observation from other studies, a PPI-induced adverse event should be considered as a possible etiology for new-onset idiopathic thrombocytopenia.

scholarly journals Repurposing Amantadine and Memantine for COVID-19: Guanylate Kinases Might Pave the Road towards Novel SARS CoV-2 and Anti Neoplastic Therapeutics.

2021 ◽  
Author(s):  
Mina Kelleni
Keyword(s):  
Potential Role ◽  
Swot Analysis ◽  
Physiological Function ◽  
Potential Interaction ◽  
Nmda Antagonists ◽  
Short Term ◽  
Guanylate Kinase ◽  
The Road

Guanylate kinase 1 (GK1) was suggested to play a crucial role in SARS CoV-2 replication and previous studies have suggested a role in the pathogenesis of some neoplasms. We are providing a concise strengths, weaknesses, opportunities, and threats (SWOT) analysis of this hypothesis while discussing guanylate kinase physiological function, pharmacological importance. Importantly, though GK1 role in SARS CoV-2 replication might prove valid, the available experimental inhibitors of GK 1 might not, at least for the short term, be safely used to manage COVID-19. However, we suggest assessing another potential interaction between SARS CoV-2 and the non-authentic membrane-associated guanylate kinases as we suggest this might add to consider the potential role of the NMDA antagonists amantadine and memantine in COVID-19 management for and we have recommended clinical trials for selected described COVID-19 patients. Finally, we also recommend conducting genetic, physiological, and immunological studies to explore the long-term potentials of novel GK-1 inhibitors suggesting they might eventually lead to a novel COVID-19 and cancer pharmacotherapeutics.

Impact of FII’s and FDI’s on Indian Stock Market

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Dr. Kamlesh Kumar Shukla
Keyword(s):  
Stock Market ◽  
Financial Markets ◽  
Global Economy ◽  
Short Term ◽  
Earnings Growth ◽  
The Past ◽  
Bull Market ◽  
Indian Stock Market

FIIs are companies registered outside India. In the past four years there has been more than $41 trillion worth of FII funds invested in India. This has been one of the major reasons on the bull market witnessing unprecedented growth with the BSE Sensex rising 221% in absolute terms in this span. The present downfall of the market too is influenced as these FIIs are taking out some of their invested money. Though there is a lot of value in this market and fundamentally there is a lot of upside in it. For long-term value investors, there’s little because for worry but short term traders are adversely getting affected by the role of FIIs are playing at the present. Investors should not panic and should remain invested in sectors where underlying earnings growth has little to do with financial markets or global economy.

Introduction: Kinship Bereavement in Later Life

1997 ◽  
Vol 35 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Brian De Vries
Keyword(s):  
Adult Child ◽  
Later Life ◽  
Short Term ◽  
Traumatic Grief ◽  
Death Of A Parent ◽  
De Vries ◽  
Longitudinal Effects ◽  
Analysis Of Variation

This article introduces a volume devoted to the examination of later-life bereavement: an analysis of variation in cause, course, and consequence. Six articles address and represent this variation and comprise this volume: 1) Prigerson et al. present case histories of the traumatic grief of spouses; 2) Hays et al. highlight the bereavement experiences of siblings in contrast to those spouses and friends; 3) Moss et al. address the role of gender in middle-aged children's responses to parent death; 4) Bower focuses on the language adopted by these adult children in accepting the death of a parent; 5) de Vries et al. explore the long-term, longitudinal effects on the psychological and somatic functioning of parents following the death of an adult child; and 6) Fry presents the short-term and longitudinal reactions of grandparents to the death of a grandchild. A concluding article is offered by de Vries stressing both the unique and common features of these varied bereavement experiences touching on some of the empirical issues and suggesting potential implications and applications.

scholarly journals Shades between Black and Green Investment: Balance or Imbalance?

2021 ◽  
Vol 13 (9) ◽  
pp. 5024
Author(s):  
 Vítor Manuel de Sousa Gabriel ◽  
María Mar Miralles-Quirós ◽  
José Luis Miralles-Quirós
Keyword(s):  
Risk Factor ◽  
Oil Prices ◽  
Oil Price ◽  
Short Term ◽  
Environmental Indices ◽  
Long Run ◽  
Green Investment ◽  
Bounds Test

This paper analyses the links established between environmental indices and the oil price adopting a double perspective, long-term and short-term relationships. For that purpose, we employ the Bounds Test and bivariate conditional heteroscedasticity models. In the long run, the pattern of behaviour of environmental indices clearly differed from that of the oil prices, and it was not possible to identify cointegrating vectors. In the short-term, it was possible to conclude that, in contemporaneous terms, the variables studied tended to follow similar paths. When the lag of the oil price variable was considered, the impacts produced on the stock market sectors were partially of a negative nature, which allows us to suppose that this variable plays the role of a risk factor for environmental investment.

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