Synthesis, Characterization and Biological Evaluation Study of Cephalexin (Ceph) and Isatin Schiff base and Its Complexation with Some Divalent Metal Ions

Metal complexes of some divalent metal ions (Co, Ni, Cu and Zn) with 3-(?- acetylethylidenehydrazino)-5,6-diphenyl-1,2,4-triazine (AHDT) as a Schiff-base have been investigated potentiometrically and spectrophotometrically and found to have the stoichiometric formulae 1:1 and 1:2 (M:L). The formation constants of the proton-ligand and metal-ligand complexes have been determined potentiometrically at different temperatures (10, 20, 30, 40 and 50?C) at an ionic strength of 0.1MKNO3 in 75%(v/v) dioxane-water solution. The standard thermodynamic parameters, viz. ?Go, ?Ho, and ?So, for the proton-ligand and the stepwise metal-ligand complexes have been evaluated.

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Spectroscopic and thermodynamic studies of complexation of some divalent metal ions with isatin-β-thiosemicarbazone

Chemical Papers ◽

10.2478/s11696-007-0066-8 ◽

2007 ◽

Vol 61 (6) ◽

Cited By ~ 1

Author(s):

S. Konstantinović ◽

B. Radovanović ◽

Z. Todorović ◽

S. Ilić ◽

B. Konstantinović

Keyword(s):

Schiff Base ◽

Metal Ions ◽

Metal Complexes ◽

Dissociation Constants ◽

Water Solution ◽

Molecular Complexes ◽

Formation Constants ◽

Divalent Metal ◽

Divalent Metal Ions ◽

Different Temperatures

AbstractMetal complexes of some divalent metal ions (Co, Ni, Cu, Zn, Hg, and Pd) with isatin-β-thiosemicarbazone (ITS) as the Schiff base have been investigated potentiometrically and spectrophotometrically. The dissociation constants of the ligand and formation constants of the metal complexes, as well as the corresponding thermodynamic functions (ΔG, ΔH and ΔS) have been determined at different temperatures in ethanol—water solution. The full stability constants were also evaluated spectrophotometrically by the Job method. The experimental results indicate that Cu(II), Zn(II), Pd(II), and Hg(II) form one-to-one molecular complexes (ML) with the studied ligand, whereas Co(II) and Ni(II) form both ML and ML2 species.

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Interaction of divalent metal ions with the NADP+-malic enzyme from maize leaves

Physiologia Plantarum ◽

10.1034/j.1399-3054.1991.810403.x ◽

1991 ◽

Vol 81 (4) ◽

pp. 462-466 ◽

Cited By ~ 2

Author(s):

Maria Fabiana Drincovich ◽

Alberto A. Iglesias ◽

Carlos S. Andreo

Keyword(s):

Metal Ions ◽

Malic Enzyme ◽

Divalent Metal ◽

Divalent Metal Ions ◽

Maize Leaves

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Synthesis, Characterization and in vitro Biological Evaluation of a New Schiff Base Derived from Drug and its Complexes with Transition Metal Ions

Revista de Chimie ◽

10.37358/rc.18.7.6393 ◽

2018 ◽

Vol 69 (7) ◽

pp. 1678-1681

Author(s):

Amina Mumtaz ◽

Tariq Mahmud ◽

M. R. J. Elsegood ◽

G. W. Weaver

Keyword(s):

Schiff Base ◽

Transition Metal ◽

Metal Ions ◽

Metal Complexes ◽

Transition Metal Complexes ◽

Free Ligand ◽

Transition Metal Ions ◽

Biological Evaluation ◽

Pyridoxal Hydrochloride

New series of copper (II), cobalt (II), zinc (II), nickel (II), manganese (II), iron (II) complexes of a novel Schiff base were prepared by the condensation of sulphadizine and pyridoxal hydrochloride. The ligand and metal complexes were characterized by utilizing different instrumental procedures like microanalysis, thermogravimetric examination and spectroscopy. The integrated ligand and transition metal complexes were screened against various bacteria and fungus. The studies demonstrated the enhanced activity of metal complexes against reported microbes when compared with free ligand.

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