Preparation and Clinical Use of Autologous Platelet Rich Plasma Eye Drops in Dogs

Purpose. To evaluate the efficacy of autologous platelet-rich plasma (E-PRP) eye drops for the treatment of chronic ocular surface syndrome (OSS) following laser in situ keratomileusis (LASIK).Methods. This prospective interventional consecutive clinical study include 156 eyes of 80 patients affected by post-LASIK chronic OSS who were treated with autologous E-PRP 6 times a day as monotherapy for 6 weeks.Results. Dry eye symptoms improved in 85% of the cases. A decrease in at least one quadrant to total disappearance on CFS was observed in 89.6% of the patients who had positive CFS before treatment. Three eyes presented severe punctate keratitis (1.9%) at baseline, all of which healed completely. Conjunctival hyperemia improved in 93.3% of the patients with previous signs of ocular surface inflammation. There was a significant improvement in logMAR CDVA from 0.14 ± 0.19 to 0.06 ± 0.12 (p=0.000), and 74 (71.4%) eyes improved at least 1 line in CDVA.Conclusion. Monotherapy with autologous E-PRP is a well-tolerated, safe, and effective treatment for the management of post-LASIK ocular surface syndrome.Precis. Monotherapy with autologous platelet-rich plasma eye drops has been shown to be an adequate option for the treatment of post-LASIK chronic ocular surface syndrome. This trial is registered withNCT03322917.

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Autologous platelet-rich plasma eye drops accelerate re-epithelialization of post-keratoplasty persistent corneal epithelial defects

Journal of Ophthalmic and Vision Research ◽

10.4103/jovr.jovr_279_17 ◽

2019 ◽

Vol 14 (2) ◽

pp. 131

Author(s):

MozhganRezaei Kanavi ◽

Shaban Alizadeh ◽

Sahar Balagholi ◽

Alireza Baradaran-Rafii ◽

Siamak Delfaza-Baher ◽

...

Keyword(s):

Platelet Rich Plasma ◽

Eye Drops ◽

Corneal Epithelial ◽

Autologous Platelet Rich Plasma ◽

Autologous Platelet

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Treatment with platelet-rich plasma of surgically related dormant corneal ulcers

European Journal of Ophthalmology ◽

10.1177/1120672117747042 ◽

2018 ◽

Vol 28 (5) ◽

pp. 515-520 ◽

Cited By ~ 11

Author(s):

Jorge L Alio ◽

Alejandra E Rodriguez ◽

Pablo De Arriba ◽

Sandra Gisbert ◽

Ahmed A Abdelghany

Keyword(s):

Platelet Rich Plasma ◽

Corneal Edema ◽

Rank Test ◽

Eye Drops ◽

Corneal Surgery ◽

Corneal Ulcers ◽

Signed Rank Test ◽

Autologous Platelet Rich Plasma ◽

A Prospective Study ◽

Autologous Platelet

Purpose: To assess the effectiveness of autologous platelet-rich plasma for the treatment of dormant corneal ulcers secondary to corneal surgery and unresponsive to conventional treatment. Setting: VISSUM, Ophthalmology Institute of Alicante, Alicante, Spain. Design: Prospective nonrandomized, observational consecutive study. Methods: A total of 44 eyes of 28 patients with dormant corneal ulcers secondary to corneal surgery were included in a prospective study and treated with autologous platelet-rich plasma during 6 weeks. Wilcoxon signed-rank test was used to compare the effect of the treatment. Results: In all, 28 patients (65.1%) improved their visual acuity at least one line in Snellen chart, 26 (59.09%) had a decrease in the size of the ulcer or even a total closure, and 40 (90.9%) experienced an improvement in their symptoms. The results are also provided for the four groups of patients (keratoplasty, refractive surgery, cross-linking, and chronic postsurgical corneal edema). Conclusion: Platelet-rich plasma eye drops shows to be a good option for the treatment of dormant corneal ulcers secondary to corneal surgery.

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