scholarly journals Relation between Helicobacter pylori infection and severity of portal hypertensive gastropathy in cirrhotic patients

2021 ◽  
Vol 2 (2) ◽  
pp. 149-157
Author(s):  
Yasser El-Dessouky ◽  
Mohamed Sekeen ◽  
Gamal El-Morsy ◽  
Ahmed Elsayed
Keyword(s):  
Helicobacter Pylori ◽  
Helicobacter Pylori Infection ◽  
Portal Hypertensive Gastropathy ◽  
Cirrhotic Patients

scholarly journals Various aspects of peptic ulcer in patients with liver cirrhosis

2018 ◽  
Vol 71 (1-2) ◽  
pp. 27-32
Author(s):  
Zeljka Savic ◽  
Dragomir Damjanov ◽  
Vladimir Vracaric ◽  
Dijana Kosijer ◽  
Dimitrije Damjanov ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Liver Cirrhosis ◽  
Peptic Ulcer ◽  
Helicobacter Pylori Infection ◽  
Ulcer Bleeding ◽  
Peptic Ulcer Bleeding ◽  
Cirrhotic Patients ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Bleeding Ulcers

Introduction. The occurrence of peptic ulcer in patients with liver cirrhosis is intriguing due to its frequency and complexity. The aim of the present study was to investigate the incidence of peptic ulcer in patients with liver cirrhosis. Results. It was found that in these patients the usual aggressive factors of the gastric environment do not play a major role in ulcerogenesis; however, researches noticed the importance of reduced mucosal defense which, in portal hypertension, has the features of hypertensive portal gastropathy. The presence of Helicobacter pylori infection in these patients is lower, compared to other patients with peptic ulcer. The prevalence of Helicobacter pylori infection decreases with the severity of liver cirrhosis. Non-steroidal anti-inflammatory drugs play an important role in peptic ulcer bleeding in cirrhotic patients, but the data are limited and contradictory. Peptic ulcer bleeding is the most frequent etiology of nonvariceal bleeding and it is associated with a great number of complications. Conclusion. Helicobacter pylori infection cannot be considered the key risk factor for the development of peptic ulcer in patients with liver cirrhosis. The role of non-steroidal anti-inflammatory drugs is accepted, although the data are controversial. The treatment of peptic ulcer in cirrhotic patients is identical to the treatment of peptic ulcer in patients without liver cirrhosis, except in cases of bleeding ulcers. There are specific therapeutic protocols for peptic ulcer bleeding in patients with liver cirrhosis.

scholarly journals Helicobacter pylori Infection in Patients with Portal Hypertensive Gastropathy Owing to Liver Cirrhosis: Prevalence and Relation with Severity of Gastropathy

2017 ◽  
Vol 08 (03) ◽  
pp. 123-128
Author(s):  
Shekhar Puri ◽  
Mukesh Jain ◽  
Kumar Shwetanshu Narayan ◽  
Sudhakar Pandey ◽  
Sandeep Nijhawan
Keyword(s):  
Helicobacter Pylori ◽  
Liver Cirrhosis ◽  
Meld Score ◽  
Upper Gastrointestinal Endoscopy ◽  
Portal Hypertensive Gastropathy ◽  
Cirrhotic Patients ◽  
The Difference ◽  
H Pylori ◽  
Ctp Score ◽  
Upper Gastrointestinal

ABSTRACT Background and Aim: Helicobacter pylori is a major human pathogen. Its role in the pathogenesis of portal hypertensive gastropathy (PHG) is debated. The aim of this study was to evaluate the prevalence of this infection in patients with portal hypertension due to liver cirrhosis and its relation with severity of gastropathy. Patients and Methods: Sixty consecutive patients with liver cirrhosis were enrolled in the study. All patients were subjected to an upper gastrointestinal endoscopy (UGIE), and rapid urease testing for H. pylori was performed. The diagnosis and severity of PHG was evaluated on UGIE. ChildαTurcotteαPugh (CTP) and model for endαstage liver disease (MELD) scores were calculated to assess the severity of liver cirrhosis. Results: H. pylori infection was reported in 33 patients with overall prevalence 55%. The presence of H. pylori was observed in 26 (67%) cirrhotic patients with PHG compared to 7 (33%) cirrhotic patients without PHG. The risk estimate showed a significant association between H. pylori and PHG in cirrhotic patients (P = 0.0133, odds ratio [OR]: 4.00, 95% confidence interval [CI]: 1.298–12.325). Out of the 26 patients with PHG and H. pylori infection, 17 had severe PHG (65.3%) and 9 had mild PHG (34.6%) whereas 4 patients had severe PHG (30.8%) and 9 had mild PHG (69.2%%) in the group of H. pyloriαnegative patients. The difference was statistically significant (P = 0.04, OR: 4.25, 95% CI: 1.0188–17.729). Of the 39 patients with PHG, 21 (53.85%) had severe PHG and 18 (46.15%) had mild PHG. No significant relation was found between H. pylori infection and severity of liver cirrhosis as regards CTP score (P = 0.76) and MELD score (P = 0.56). Conclusion: Our results showed a significant association between H. pylori infection and the occurrence and also the severity of gastropathy in patients with liver cirrhosis. Yet, the severity of liver cirrhosis itself did not correlate with H. pylori or the severity of gastropathy.

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