scholarly journals Complex Nature of Neural Tube Defects: A Regional Experience

2018 ◽  
Vol 24 (3) ◽  
pp. 119
Author(s):  
Emrah Turhan ◽  
Fusun G Varol ◽  
Hakan Gurkan ◽  
Cenk N. Sayin
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Neural Tube Defect ◽  
Methylenetetrahydrofolate Reductase ◽  
Maternal Serum ◽  
Northwestern Region ◽  
Zinc Levels ◽  
Serum Folic Acid

<p><strong>Objective:</strong> The underlying gene-environment interaction of fetal neural tube defects is affected by several factors including geography, ethnicity and time. Local features of fetal neural tube defects were described.<br /><strong></strong></p><p><strong>Study Design:</strong> A prospective cohort study of 48 fetal neural tube defects in a single tertiary medical center at the northwestern region of Turkey (2013-2015) was done via ultrasound, magnetic resonance imaging (MRI), conventional karyotyping, maternal methylenetetrahydrofolate reductase c.677C&gt;T (rs1801133) single-nucleotide polymorphism and maternal serum levels of folic acid, vitamin B12 and zinc. For comparison of means, a Student’s T-Test was used.</p><p><strong>Results:</strong> The prevalence of neural tube defects was 11.4 per 10000 births (48/42000) in northwestern Turkey. The defects on the cranium (n=23; 47.9%) and spine (n=25; 52.1%) were ultrasonographically detected. MRI did not give additional benefit over the ultrasonography. The ratio of associated anomalies in neural tube defect group was 25%. Two fetal neural tube defects with Down syndrome were remarkable. The rate of homozygous methylenetetrahydrofolate reductase c.677C &gt; T SNPs among the mothers of neural tube defect fetuses (n=20) was 15%. Comparing with gestationally matched healthy pregnancies, although maternal BMIs and periconceptional folate intake of neural tube defect group were significantly different, maternal serum folic acid, vitamin B12 and zinc levels were similar.</p><p><strong>Conclusion:</strong> The northwestern region appeared to be a relatively low prevalence area of Turkey for fetal neural tube defects. Any association with maternal serum folic acid, vitamin B12 and zinc levels could not be shown in this region.</p>

scholarly journals Maternal Vitamin B12 Status and Risk of Neural Tube Defects in a Population With High Neural Tube Defect Prevalence and No Folic Acid Fortification

PEDIATRICS ◽  
2009 ◽  
Vol 123 (3) ◽  
pp. 917-923 ◽  
Author(s):  
A. M. Molloy ◽  
P. N. Kirke ◽  
J. F. Troendle ◽  
H. Burke ◽  
M. Sutton ◽  
...  
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Neural Tube Defect ◽  
Folic Acid Fortification ◽  
Maternal Vitamin

Drug and Environmental Factors Associated with Adverse Pregnancy Outcomes Part III: Folic Acid: Pharmacology, Therapeutic Recommendations, and Economics

1998 ◽  
Vol 32 (10) ◽  
pp. 1087-1095 ◽  
Author(s):  
Dale P Lewis ◽  
Don C Van Dyke ◽  
Phyllis J Stumbo ◽  
Mary J Berg
Keyword(s):  
Folic Acid ◽  
Mechanism Of Action ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Neural Tube Defect ◽  
Methylenetetrahydrofolate Reductase ◽  
Folate Intake ◽  
Cardiovascular Morbidity And Mortality ◽  
Cereal Grain ◽  
Therapeutic Recommendations

OBJECTIVE: To review folic acid's mechanism of action, adverse effects, therapeutic recommendations, compliance, and cost. DATA SOURCES: A MEDLINE search was conducted through December 1997. Additional sources were obtained from Current Contents and citations from the references obtained. Search terms included folate, folic acid, neural tube defect, homocysteine, and methylenetetrahydrofolate reductase. STUDY SELECTION: Animal and human studies examining the effects of folate were reviewed. DATA EXTRACTION: Data collected included mechanism of action, safety issues, dosing recommendations, compliance with recommendations, and economics. DATA SYNTHESIS: Folic acid decreases neural tube defect risk through an effect on methionine–homocysteine metabolism. In addition, increased folate intake may reduce cardiovascular morbidity and mortality. Since toxicity is minimal, everyone can potentially benefit from increased folate consumption. To help achieve this, the Food and Drug Administration has mandated that cereal grain be fortified with 140 μg of folic acid per 100 g of grain, which will add approximately 0.1 mg of folate to the average diet. Studies recommend supplementing with 0.2 mg to promote optimal homocysteine concentrations and for preventing neural tube defects. CONCLUSIONS: Despite fortification, most women will still receive less folate than the 0.4 mg/d recommended by the Public Health Service. All population groups would benefit from increased folate intake. Current studies indicate 200 μg/d may be the minimum effective amount of fortification needed for normalizing homocysteine concentrations and preventing a significant number of neural tube defects; thus, a higher level of food fortification may be warranted.

scholarly journals Level of Folic Acid and Vitamin B12 in Mothers and Children with Neural Tube Defect

2015 ◽  
Vol 8 (1-3) ◽  
pp. 14-18
Author(s):  
Amalia Tri Utami ◽  
Siti Chandra Windu Baktiyani ◽  
Moch. Istiadjid Eddy Santosa
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Neural Tube ◽  
Neural Tube Defect ◽  
Mothers And Children

Vitamin B12 and the Risk of Neural Tube Defects in a Folic-Acid-Fortified Population

Epidemiology ◽  
2007 ◽  
Vol 18 (3) ◽  
pp. 362-366 ◽  
Author(s):  
Joel G. Ray ◽  
Philip R. Wyatt ◽  
Miles D. Thompson ◽  
Marian J. Vermeulen ◽  
Chris Meier ◽  
...  
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Neural Tube ◽  
Neural Tube Defects

Relation Between the Levels of Folic Acid, Vitamin B12 and Maternal Homocysteine With Neural Tube Defects and Cleft Lip

Epidemiology ◽  
2006 ◽  
Vol 17 (Suppl) ◽  
pp. S320 ◽  
Author(s):  
D V Chávez-Corral ◽  
M DR Velazco-Campos ◽  
L H Sanin ◽  
M Levario-Carrillo ◽  
A A Aguirre-Rodríguez ◽  
...  
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Cleft Lip

Folate Supplements Should Be Appropriately Labeled to Protect Consumers

PEDIATRICS ◽  
1994 ◽  
Vol 93 (4) ◽  
pp. 694-695
Author(s):  
Victor Herbert
Keyword(s):  
Folic Acid ◽  
Disease Control ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Neural Tube Defect ◽  
Folate Supplementation ◽  
Over The Counter ◽  
Control And Prevention ◽  
Centers For Disease Control ◽  
September Issue

Caveats are needed regarding the Academy of Pediatrics policy statement1 (in the September issue of Pediatrics) advising all women capable of becoming pregnant to take a daily over-the-counter multivitamin containing 0.4 mg of folic acid to reduce the frequency of neural tube defect (NTD) babies. I provided similar advice in my 1992 paper, "Folate and Neural Tube Defects".2 However, in that paper I discussed important caveats. I repeated and extended those caveats at the August 12, 1993, Centers for Disease Control and Prevention (CDC) meeting on monitoring the effects of folate supplementation.

scholarly journals Balanced Essential Micronutrients during Pregnancy: High Concern

2018 ◽  
Vol 4 (2) ◽  
pp. 259-261
Author(s):  
Srilatha Bashetti ◽  
Kumar SaiSailesh ◽  
Aparna Varma ◽  
Rajagopalan Vijayaraghavan
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Carbon Metabolism ◽  
Strong Predictor ◽  
Fetal Loss ◽  
Folate Deficiency ◽  
Cobalamin Deficiency ◽  
One Carbon Metabolism

Nutrition and epigenetic changes is the emerging topic of interest in the present scenario to understand the effects of increased supplementation of micronutrients like Folic Acid (FA). The study is taken up in the public health interest, to evaluate the importance of balancing the different micronutrients in the diet to avoid unbalanced nutritional disorders and other health complications later in life. It has been hypothesized that disease risks after birth or later in life can be determined by paternal or maternal diet. This raised an interest to study in-utero effects of environmental exposures like air pollution, toxins, nutrition, etc. It had been assumed that during embryonic period most of the dividing tissues get exposed to the environmental insults and that change results in predisposition of cancer or other health outcomes. There could be the possibility of maternal exposures like nutrition may alter the intrauterine one-carbon metabolism or the precursor milieu and may be involved in the disruption of one-carbon metabolism in developing offspring. Modification in methyl me of offspring with subsequent changes in phenotypes has been noted in the preliminary studies with increased folic acid (FA) supplementation during pregnancy. Maternal folate deficiency has been implicated as a cause of prematurity and both folate deficiency and cobalamin deficiency have been implicated in recurrent fetal loss and neural tube defects. Folic acid supplementation at the time of conception and in the first 12 weeks of pregnancy is expected to reduce by 70% the incidence of neural tube defects (NTDs) (meningomyelocele, encephalocele and spina bifida) in the fetus. Most of the protective effect can be achieved by taking folic acid, 0.4 mg daily at the time of conception. However there is no clear relationship between maternal folatestatus and the fetal abnormalities. It has been observed that, the lower the maternal folate, the greater the risk to the fetus. On the other hand maternal cobalamin status is a strong predictor of vitamin B12 in breastfed infants up to at least 6 months of age. Because of the transfer from mother to offspring during pregnancy and lactation, maternal requirements during this period are increased and deficiency may occur. The influence of low vitamin B12 during pregnancy may have cognitive ability of children later in life. Hypothyroidism is caused by insufficient production of thyroid hormones by the thyroid gland. In females, hypothyroidism is associated mainly with oligomenorrhea.

scholarly journals Neural Tube Defects: A case report

2018 ◽  
Vol 14 (4) ◽  
pp. 228-230
Author(s):  
Bishnu Gautam
Keyword(s):  
Folic Acid ◽  
Case Report ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Neural Tube Defect ◽  
Prenatal Counseling ◽  
Folic Acid Supplement ◽  
Folic Acid Supplements ◽  
Period Of Gestation

Neural tube defect is rare congenital defect of fetus. I have a case of 13 weeks period of gestation with meningomeyelocele came for termination of pregnancy. The diagnosis was confirmed by ultrasonography. History suggests that patient had previous neural tube defect baby, non-compliance to folic acid supplements. It is concluded that prenatal counseling, adherence to folic acid supplement and regular follow-up can prevent further complication.

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