A STUDY OF ASSOCIATION OF SERUM FOLIC ACID LEVEL WITH PRE ECLAMPSIA IN DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY AT SMS MEDICAL COLLEGE, JAIPUR

Background: In this study was carried out to determine the relation between serum levels of Folic Acid and preeclampsia among pregnant women. Methods: Methods- Hospital based comparative study was conducted at Department of Obstetrics and Gynaecology, SMS medical college, Jaipur. Results: In PIH group, 20.00% women folic acid level was 3.1-7.8 ng/ml, 40.00% women folic acid level was 7.9-12.6 ng/ml, 35.00% women folic acid level was 12.7-17.5 ng/ml and 5.00% women folic acid level was 17.6-20.00 ng/ml. In normotensive group, 5.00% women folic acid level was 3.1-7.8 ng/ml, 25.00% women folic acid level was 7.9-12.6 ng/ml, 50.00% women folic acid level was 12.7-17.5 ng/ml and 20.00% women folic acid level was 17.6-20.00 ng/ml. Conclusion: We conclude that folic acid is not the only element in preventing the preeclampsia, however, its serum level in case group is significantly less than control group. Keywords: Eclampsia, Folic acid, Hypertension

Congenital Isolated Folic Acid Malabsorption: Case Report

We report the case of a female child with congenital isolated malabsorption of folic acid. The patient was referred to our hospital for pancytopenia and a tendency to various infections, but with no neurological disturbances. A bone marrow aspiration demonstrated megalobastic anemia and serum folic acid was low. An immunodeficiency test was therefore performed, which revealed impairment of both cellular and humoral immunity. The defect persisted after considerable doses of folate were administered orally to the patient. However, parenteral administration of folic acid removed pancytopenia, and restored normal levels of T CD8+, NK, B and immunoglobulins. Our patient, responded only to parenteral folate and her immunologic recovery after parenteral folate repletion was dramatic and provides strong in vivo evidence of the importance of folates for lymphocyte function in humans. Our patient’s history shows that while it is easy to reverse the systemic consequences of folate deficiency, patients must not stop taking their folate supplementation because they believe that their disorder disappeared.