Prenatal and postnatal treatment of 3-phosphoglycerate-dehydrogenase deficiency with L-serine improved fetal brain growth

2004 ◽  
Vol &NA; (1468) ◽  
pp. 18
Author(s):  
&NA;
Keyword(s):  
Dehydrogenase Deficiency ◽  
Fetal Brain ◽  
Brain Growth ◽  
Postnatal Treatment ◽  
Phosphoglycerate Dehydrogenase

Prenatal and early postnatal treatment in 3-phosphoglycerate-dehydrogenase deficiency

The Lancet ◽  
2004 ◽  
Vol 364 (9452) ◽  
pp. 2221-2222 ◽  
Author(s):  
TJ de Koning ◽  
LWJ Klomp ◽  
ACC van Oppen ◽  
FA Beemer ◽  
L Dorland ◽  
...  
Keyword(s):  
Dehydrogenase Deficiency ◽  
Postnatal Treatment ◽  
Phosphoglycerate Dehydrogenase

scholarly journals Neuroplacentology in congenital heart disease: placental connections to neurodevelopmental outcomes

2021 ◽  
Author(s):  
Rachel L. Leon ◽  
Imran N. Mir ◽  
Christina L. Herrera ◽  
Kavita Sharma ◽  
Catherine Y. Spong ◽  
...  
Keyword(s):  
Brain Development ◽  
Congenital Heart ◽  
Fetal Brain ◽  
In Utero ◽  
Structure And Function ◽  
Brain Growth ◽  
Neurodevelopmental Outcomes ◽  
Fetal Brain Development ◽  
And Function

Abstract Children with congenital heart disease (CHD) are living longer due to effective medical and surgical management. However, the majority have neurodevelopmental delays or disorders. The role of the placenta in fetal brain development is unclear and is the focus of an emerging field known as neuroplacentology. In this review, we summarize neurodevelopmental outcomes in CHD and their brain imaging correlates both in utero and postnatally. We review differences in the structure and function of the placenta in pregnancies complicated by fetal CHD and introduce the concept of a placental inefficiency phenotype that occurs in severe forms of fetal CHD, characterized by a myriad of pathologies. We propose that in CHD placental dysfunction contributes to decreased fetal cerebral oxygen delivery resulting in poor brain growth, brain abnormalities, and impaired neurodevelopment. We conclude the review with key areas for future research in neuroplacentology in the fetal CHD population, including (1) differences in structure and function of the CHD placenta, (2) modifiable and nonmodifiable factors that impact the hemodynamic balance between placental and cerebral circulations, (3) interventions to improve placental function and protect brain development in utero, and (4) the role of genetic and epigenetic influences on the placenta–heart–brain connection. Impact Neuroplacentology seeks to understand placental connections to fetal brain development. In fetuses with CHD, brain growth abnormalities begin in utero. Placental microstructure as well as perfusion and function are abnormal in fetal CHD.

scholarly journals Association of Prenatal Maternal Psychological Distress With Fetal Brain Growth, Metabolism, and Cortical Maturation

2020 ◽  
Vol 3 (1) ◽  
pp. e1919940 ◽  
Author(s):  
Yao Wu ◽  
Yuan-Chiao Lu ◽  
Marni Jacobs ◽  
Subechhya Pradhan ◽  
Kushal Kapse ◽  
...  
Keyword(s):  
Psychological Distress ◽  
Fetal Brain ◽  
Brain Growth ◽  
Maternal Psychological Distress ◽  
Growth Metabolism ◽  
Cortical Maturation

Maternal Immune Activation in the Rat Alters Maternofetal Leucine Transport and Fetal Brain Growth

Placenta ◽  
2021 ◽  
Vol 112 ◽  
pp. e13
Author(s):  
Hager M. Kowash ◽  
Harry G. Potter ◽  
Nick Ashton ◽  
Reinmar Hager ◽  
Joanna C. Neill ◽  
...  
Keyword(s):  
Immune Activation ◽  
Fetal Brain ◽  
Brain Growth ◽  
Maternal Immune Activation ◽  
Leucine Transport

scholarly journals Folic Acid Intake, Fetal Brain Growth, and Maternal Smoking in Pregnancy: A Randomized Controlled Trial

2019 ◽  
Vol 3 (6) ◽  
Author(s):  
Korede K Yusuf ◽  
Hamisu M Salihu ◽  
Roneé Wilson ◽  
Alfred Mbah ◽  
William Sappenfield ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Folic Acid ◽  
Maternal Smoking ◽  
Controlled Trial ◽  
Fetal Brain ◽  
Brain Growth ◽  
Folic Acid Intake ◽  
Randomized Controlled ◽  
Smoking In Pregnancy ◽  
In Pregnancy

scholarly journals Expanding the clinical spectrum of 3-phosphoglycerate dehydrogenase deficiency

2010 ◽  
Vol 34 (1) ◽  
pp. 181-184 ◽  
Author(s):  
L. Tabatabaie ◽  
L. W. J. Klomp ◽  
M. E. Rubio-Gozalbo ◽  
L. J. M. Spaapen ◽  
A. A. M. Haagen ◽  
...  
Keyword(s):  
Dehydrogenase Deficiency ◽  
Clinical Spectrum ◽  
Phosphoglycerate Dehydrogenase

Normative fetal brain growth by quantitative in vivo magnetic resonance imaging

2012 ◽  
Vol 206 (2) ◽  
pp. 173.e1-173.e8 ◽  
Author(s):  
Cedric Clouchoux ◽  
Nicolas Guizard ◽  
Alan Charles Evans ◽  
Adre Jacques du Plessis ◽  
Catherine Limperopoulos
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Fetal Brain ◽  
Brain Growth ◽  
Resonance Imaging

scholarly journals Molecular Characterization of 3-Phosphoglycerate Dehydrogenase Deficiency—a Neurometabolic Disorder Associated with Reduced L-Serine Biosynthesis

2000 ◽  
Vol 67 (6) ◽  
pp. 1389-1399 ◽  
Author(s):  
Leo W.J. Klomp ◽  
Tom J. de Koning ◽  
Helga E.M. Malingré ◽  
Ellen A.C.M. van Beurden ◽  
Miny Brink ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Dehydrogenase Deficiency ◽  
Neurometabolic Disorder ◽  
Phosphoglycerate Dehydrogenase ◽  
Serine Biosynthesis
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