Influence of a Fourier-domain OCT software version development on the detection of ganglion cell complex changes due to cataract surgery

ABSTRACT: PURPOSE: To study the changes in Ganglion Cell Complex as measured on OCT after phacoemulsification with intra ocular lens implantation. STUDY DESIGN: Quasi experimental study PLACE AND DURATION OF STUDY: Department of Ophthalmology, Lahore General Hospital, Lahore from 1-3-2017 to 30-4-2018 MATERIALS AND METHODS: Ethical approval of the study was obtained from ‘’Ethical Review Committee’’ of Lahore General Hospital, Lahore. Patients presenting to the Eye OPD Lahore General Hospital were assessed for inclusion and exclusion criteria. All patients (n=64) diagnosed with cataract requiring surgery were included in study. Patients having any coexisting ocular pathology hindering the OCT measurement i.e. Corneal opacity, Vitreous hemorrhage, Retinal detachment were excluded from study. Retinal Ganglion Cell Complex thickness was measured in Superior, Inferior, Supero-Nasal, Supero-Temporal, Infero-Nasal and Infero-Temporal quadrants. Besides that Signal Strength on OCT was also documented. Pre-Operatively, Visual acuity was measured and OCT performed and the findings were recorded on a designed proforma. Post-Operatively, the patients were called for follow-up after one month at which time Visual acuity was again measured and OCT performed and findings recorded in the proforma. All the surgeries were performed by single surgeon. RESULTS: The thickness of Ganglion Cell Complex increased significantly (p<0.001) one month after cataract surgery. CONCLUSION: Cataract surgery does affect the measurement of Retinal Ganglion Cell Complex thickness on OCT.

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Effect of myopia on ganglion cell complex and peripapillary retinal nerve fibre layer measurements: a Fourier-domain optical coherence tomography study of young Chinese persons

Clinical and Experimental Ophthalmology ◽

10.1111/ceo.12045 ◽

2013 ◽

Vol 41 (6) ◽

pp. 561-566 ◽

Cited By ~ 18

Author(s):

Zhennan Zhao ◽

Chunhui Jiang

Keyword(s):

Optical Coherence Tomography ◽

Ganglion Cell ◽

Nerve Fibre ◽

Retinal Nerve Fibre Layer ◽

Cell Complex ◽

Ganglion Cell Complex ◽

Fourier Domain ◽

Optical Coherence ◽

Fibre Layer ◽

Nerve Fibre Layer

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Changes in Ganglion Cell Complex and Peripapillary Retinal Nerve Fiber Layer after Femtosecond Laser-Assisted Cataract Surgery Compared to Manual Phacoemulsification in Patients Receiving a Trifocal Intraocular Lens

Journal of Ophthalmology ◽

10.1155/2020/8626495 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Carmen Sánchez-Sánchez ◽

Laureano A. Rementería-Capelo ◽

Virginia Carrillo ◽

Juan Pérez-Lanzac ◽

Inés Contreras

Keyword(s):

Femtosecond Laser ◽

Cataract Surgery ◽

Ganglion Cell ◽

Nerve Fiber ◽

Intraocular Lens ◽

Retinal Nerve Fiber Layer ◽

Cell Complex ◽

Ganglion Cell Complex ◽

Fiber Layer ◽

Nerve Fiber Layer

Introduction. During femtosecond laser-assisted cataract surgery (FLACS), there is a significant increase in intraocular pressure, which might lead to ganglion cell damage. We aimed to determine whether there were differences in the changes produced in the ganglion cell complex (GCC) and peripapillary retinal nerve fiber layer (pRNFL) thickness, as evaluated with optical coherence tomography (OCT), between phacoemulsification and FLACS, after implantation of a trifocal intraocular lens (IOL). Methods. Patients with no coexistent pathologies undergoing cataract surgery with implantation of a PanOptix IOL were explored with the Cirrus-OCT before and three months after surgery. GCC values were obtained from the built-in software. The differences between pre- and postoperative GCC and pRNFL thicknesses after phacoemulsification were compared to differences after FLACS. Results. A total of 171 eyes were included, 74 undergoing FLACS and 97 phacoemulsification. For both groups, there was a statistically significant increase in GCC values after cataract surgery, except for the inferior and inferonasal sectors. There were no statistically significant differences between FLACS and phacoemulsification. Mean change in average GCC and minimum GCC were 1.08 ± 1.40 µm (range −1 to +6 µm) and 1.69 ± 2.54 µm (range −3 to +11 µm) after FLACS and 0.99 ± 1.67 µm (range −5 to +6 µm) and 2.02 ± 3.54 µm (−6 to +18 µm) after phacoemulsification. These values are similar to those previously reported after phacoemulsification with monofocal IOL implantation. No significant changes after surgery were detected for the pRNFL, with no differences between groups. Discussion. There were no differences in the changes produced by FLACS and phacoemulsification in either GCC or pRNFL values. Although mean change was small, the range of variation was wide. Therefore, it is necessary to establish a new baseline for GCC and pRNFL thicknesses after cataract surgery in order to monitor any subsequent changes.

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