Extensive Coronary Thrombosis in a COVID-19 Patient

SummaryIn the present paper described is a simple test for detecting soluble fibrin monomer complexes (SFMC) in blood. The test consists in mixing 1% protamine sulphate with diluted oxalated plasma or serum and reading the optical density at 6190 Å. In experiments with dog plasma, enriched with soluble fibrin complexes, it was shown that OD read in PS test is proportional to the amount of fibrin recovered from the precipitate. It was found that SFMC level in plasma increases in rabbits infused intravenously with thrombin and decreases after injection of plasmin with streptokinase. In both cases PS precipitable protein in serum is elevated indicating enhanced fibrinolysis. In healthy human subjects the mean value of OD readings in plasma and sera were found to be 0.30 and 0.11, while in patients with coronary thrombosis they are 0.64 and 0.05 respectively. The origin of SFMC in circulation under physiological and pathological conditions is discussed.

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Release of Platelet Factor 4 in Vivo during Intravascular Coagulation and in Thrombotic States

Thrombosis and Haemostasis ◽

10.1055/s-0038-1651237 ◽

1968 ◽

Vol 19 (03/04) ◽

pp. 578-583 ◽

Cited By ~ 11

Author(s):

R Farbiszewski ◽

S Niewiarowski ◽

K Worowski ◽

B Lipiński

Keyword(s):

Coronary Thrombosis ◽

Laboratory Diagnosis ◽

Tolerance Test ◽

Platelet Factor 4 ◽

Thrombin Time ◽

Significant Elevation ◽

Platelet Factor ◽

Thrombotic Diseases ◽

Disseminated Intravascular Clotting

SummaryPlatelet factor 4 released from platelets into the circulating blood was determined using both the heparin thrombin time and paracoagulation methods. It has been found that thrombin injected intravenously into rabbits releases large amounts of this factor. Infusion of plasmin does not release this factor and this finding may be of importance for the differential diagnosis between disseminated intravascular clotting and primary fibrinolysis. PF4 is not released during the hyper coagulable condition induced by HgCl2 intoxication. Only small amounts of this factor are released after contact factor infusion.A significant elevation of extraplatelet PF4 was found in 23 patients with fresh coronary thrombosis and in 9 patients with thrombophlebitis and thromboembolic complications.The significance of the above findings for the pathogenesis, treatment and laboratory diagnosis of thrombotic diseases with particular reference to heparin tolerance test is discussed.

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The Association of Hyperestrogenemia With Coronary Thrombosis in Men

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/01.atv.16.11.1383 ◽

1996 ◽

Vol 16 (11) ◽

pp. 1383-1387 ◽

Cited By ~ 27

Author(s):

Gerald B. Phillips ◽

Bruce H. Pinkernell ◽

Tian-Yi Jing

Keyword(s):

Coronary Thrombosis

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THE FATTY MEAL, AND CORONARY THROMBOSIS

The Medical Journal of Australia ◽

10.5694/j.1326-5377.1960.tb23959.x ◽

1960 ◽

Vol 2 (24) ◽

pp. 955-955 ◽

Cited By ~ 1

Keyword(s):

Coronary Thrombosis ◽

Fatty Meal

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Diagnosing coronary thrombosis using multiphase post-mortem CT angiography (MPMCTA): A case study

Medicine Science and the Law ◽

10.1177/0025802420923175 ◽

2021 ◽

Vol 61 (1_suppl) ◽

pp. 77-81

Author(s):

Camatti Jessika ◽

Santunione Anna Laura ◽

Draisci Stefano ◽

Gangi Bruno Giuliano ◽

Bisceglia Marco ◽

...

Keyword(s):

Ct Angiography ◽

Coronary Thrombosis ◽

Filling Defect ◽

Forensic Radiology ◽

Criminal Court ◽

Post Mortem ◽

Reference Standard ◽

Solid Foundation ◽

Court Proceedings

While post-mortem angiography (PMA) is gradually establishing its role in Forensic Radiology, the available literature in Italy lacks a solid foundation, particularly regarding its use in criminal court proceedings. An illustrative example of multiphase post-mortem CT angiography (MPMCTA) is presented here to encourage the systematic implementation of PMA methods. To demonstrate concordance between MPMCTA and the reference standard (autopsy and histology) in a case of acute coronary thrombosis, we report a case where MPMCTA, autopsy, histological and toxicological analyses were performed on a previously healthy 51-year-old man. MPMCTA detected a right coronary artery filling defect that could be ascribed to coronary thrombosis, which was later confirmed by autopsy and histological examinations.

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