A Novel Amino Acid Properties Selection Method for Protein Fold Classification

2020 ◽  
Vol 27 (4) ◽  
pp. 287-294 ◽  
Author(s):  
Lichao Zhang ◽  
Liang Kong

Background: Amino acid physicochemical properties encoded in protein primary structure play a crucial role in protein folding. However, it is not yet clear which of the properties are the most suitable for protein fold classification. Objective: To avoid exhaustively searching the total properties space, an amino acid properties selection method was proposed in this study to rapidly obtain a suitable properties combination for protein fold classification. Method: The proposed amino acid properties selection method was based on sequential floating forward selection strategy. Beginning with an empty set, variable number of features were added iteratively until achieving the iteration termination condition. Results: The experimental results indicate that the proposed method improved prediction accuracies by 0.26-5% on a widely used benchmark dataset with appropriately selected amino acid properties. Conclusion: The proposed properties selection method can be extended to other biomolecule property related classification problems in bioinformatics.

2013 ◽  
Vol 804 ◽  
pp. 70-75 ◽  
Author(s):  
Jian-Hua Huang ◽  
Hua-Lin Xie ◽  
Jun Yan ◽  
Hong-Mei Lu ◽  
Qing-Song Xu ◽  
...  

Biochimie ◽  
2014 ◽  
Vol 103 ◽  
pp. 1-6 ◽  
Author(s):  
Jian-Hua Huang ◽  
Ming Wen ◽  
Li-Juan Tang ◽  
Hua-Lin Xie ◽  
Liang Fu ◽  
...  

Amino Acids ◽  
2008 ◽  
Vol 35 (3) ◽  
pp. 615-626 ◽  
Author(s):  
Tze-Chuen Lee ◽  
Ann S. G. Lee ◽  
Kuo-Bin Li

Sign in / Sign up

Export Citation Format

Share Document