Study on Medicinal Chemistry of K203 in Wistar Rats and Beagle Dogs

2013 ◽  
Vol 20 (16) ◽  
pp. 2137-2144 ◽  
Author(s):  
H. Kalasz ◽  
P. Szegi ◽  
G. Janoki ◽  
L. Balogh ◽  
Z. Postenyi ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Medicinal Chemistry ◽  
Beagle Dogs

Spontaneous lesions in endocrine glands of experimental Wistar rats and beagle dogs

2016 ◽  
Vol 68 (1) ◽  
pp. 1-13 ◽  
Author(s):  
G.J. Nataraju ◽  
Ramchandra K. Ranvir ◽  
Viren R. Kothule ◽  
Shekhar B. Kadam ◽  
B.V. Ravichandra ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Endocrine Glands ◽  
Beagle Dogs

Preclinical 28-Day Inhalation Toxicity Assessment of S-Nitrosoglutathione in Beagle Dogs and Wistar Rats

2011 ◽  
Vol 30 (5) ◽  
pp. 466-477 ◽  
Author(s):  
Dorothy B. Colagiovanni ◽  
Daxa Borkhataria ◽  
Doug Looker ◽  
Detlef Schuler ◽  
Corinna Bachmann ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Therapeutic Agent ◽  
Recovery Period ◽  
Clinical Pathology ◽  
Toxicity Assessment ◽  
Clinical Development ◽  
Inhalation Toxicity ◽  
Toxicity Profile ◽  
Beagle Dogs ◽  
Related Compounds

To support clinical development of S-nitrosoglutathione (GSNO) as a therapeutic agent, 28-day toxicology studies in rats and dogs were conducted. Rats (21-25/sex) and dogs (3-5/sex) were exposed for 4 hours or 1 hour, respectively, to inhaled GSNO (0, 3, 9.3, 19, and 28 mg/kg per d in rats and 0, 4.6, 9.0, and 16.2 mg/kg per d in dogs) or vehicle daily via a nebulizer. Animals were monitored throughout the 28-day dosing period and during a postexposure recovery period. Complete necropsy and tissue examinations were performed. Experimental end points included clinical pathology, toxicokinetics, and immunotoxicology. No biologically significant adverse findings were noted in either species, and the no observed adverse effect levels (NOAELs) under these conditions were the highest achieved doses (28 and 16.2 mg/kg per d in rats and dogs, respectively). These data demonstrate that GSNO is well tolerated in rodents and dogs and predict a favorable toxicity profile in humans, thus supporting future clinical development of GSNO or closely related compounds.

Chronic Toxicity Studies with Thiram in Wistar Rats and Beagle Dogs

1991 ◽  
Vol 16 (4) ◽  
pp. 667-686 ◽  
Author(s):  
K. MAITA ◽  
S. TSUDA ◽  
Y. SHIRASU
Keyword(s):  
Wistar Rats ◽  
Chronic Toxicity ◽  
Beagle Dogs ◽  
Toxicity Studies

Carcinogenicity and chronic toxicity of copovidone (Kollidon VA 64) in Wistar rats and Beagle dogs

2004 ◽  
Vol 42 (10) ◽  
pp. 1573-1587 ◽  
Author(s):  
W. Mellert ◽  
K. Deckardt ◽  
C. Gembardt ◽  
B. Hildebrand ◽  
S. Schulte
Keyword(s):  
Wistar Rats ◽  
Chronic Toxicity ◽  
Beagle Dogs

The ferret, Mustela putorius furo, as a new species in toxicology

1979 ◽  
Vol 13 (2) ◽  
pp. 119-124 ◽  
Author(s):  
P. C. Thornton ◽  
Pauline A. Wright ◽  
P. J. Sacra ◽  
T. E. W. Goodier
Keyword(s):  
New Species ◽  
Wistar Rats ◽  
Serum Chemistry ◽  
Beagle Dogs ◽  
Weight Changes ◽  
Mustela Putorius ◽  
Serum Electrolytes ◽  
Glucose Levels ◽  
A New Species ◽  
Common Laboratory

Summary Comprehensive studies on the haematology, urine chemistry, serum chemistry and gross pathology have been carried out and reported. Seasonal weight changes were confirmed and were initiated, together with sexual activity, when ferrets were brought in to a constant temperature (18–19°C) and 14–hour daylight cycle during the winter months. Levels of haemoglobin, erythrocytes and haematocrit were higher than in most common laboratory species. Similarly, serum electrolytes and glucose levels were higher than in Wistar rats or beagle dogs. Ovaries, uteri and testes displayed a seasonal maturation and atrophy. All other parameters were similar to common laboratory species.

The Clinical, Roentgenological and Morphological Effects of an Acute Exposure of Phosgene on the Lungs of Dogs

1971 ◽  
Vol 29 ◽  
pp. 236-237
Author(s):  
R. F. Bils ◽  
W. F. Diller ◽  
F. Huth
Keyword(s):  
Latent Period ◽  
Chemical Industry ◽  
Toxic Substance ◽  
Lung Edema ◽  
X Rays ◽  
Beagle Dogs ◽  
Male And Female ◽  
Morphological Alterations ◽  
Before And After ◽  
Electron Microscopes

Phosgene still plays an important role as a toxic substance in the chemical industry. Thiess (1968) recently reported observations on numerous cases of phosgene poisoning. A serious difficulty in the clinical handling of phosgene poisoning cases is a relatively long latent period, up to 12 hours, with no obvious signs of severity. At about 12 hours heavy lung edema appears suddenly, however changes can be seen in routine X-rays taken after only a few hours' exposure (Diller et al., 1969). This study was undertaken to correlate these early changes seen by the roengenologist with morphological alterations in the lungs seen in the'light and electron microscopes.Forty-two adult male and female Beagle dogs were selected for these exposure experiments. Treated animals were exposed to 94.5-107-5 ppm phosgene for 10 min. in a 15 m3 chamber. Roentgenograms were made of the thorax of each animal before and after exposure, up to 24 hrs.

Ultrastructural Investigation of Spontaneous Pituitary Adenomas in Aging Sprague-Dawley Rats

1982 ◽  
Vol 40 ◽  
pp. 216-217
Author(s):  
D. J. McComb ◽  
J. Beri ◽  
F. Zak ◽  
K. Kovacs
Keyword(s):  
Microscopic Study ◽  
Pituitary Adenomas ◽  
Wistar Rats ◽  
Microscopic Level ◽  
Sprague Dawley ◽  
Prolactin Cells ◽  
Light Microscopic Level ◽  
Ultrastructural Investigation ◽  
Sprague Dawley Rats ◽  
Long Evans

Investigation of the spontaneous pituitary adenomas in rat have been limited mainly to light microscopic study. Furth et al. (1973) described them as chromophobic, secreting prolactin. Kovacs et al. (1977) in an ul trastructural investigation of adenomas of old female Long-Evans rats, found that they were composed of prolactin cells. Berkvens et al. (1980) using immunocytochemistry at the light microscopic level, demonstrated that some spontaneous tumors of old Wistar rats could contain GH, TSH or ACTH as well as PRL.

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