:
Trans-resveratrol (RESV), pterostilbene, trans-piceid and trans-viniferins are bioactive stilbenes present in
grapes and other plants. Several groups applied biotechnology to introduce their synthesis in plant crops. Biochemical
interaction with enzymes, regulation of non-coding RNAs, and activation of signaling pathways and transcription factors
are among the main effects described in literature. However, solubility in ethanol, short half-life, metabolism by gut
bacteria, make difficult to achieve the concentration responsible for the effects observed in cultured cells. Derivatives
obtained by synthesis, trans-resveratrol analogs and methoxylated stilbenes show to be more stable and allow the
synthesis of bioactive compounds with higher bioavailability. However, changes in chemical structure may require testing
for toxicity. Thus, delivery of RESV and its natural analogs incorporated into liposomes or nanoparticles, is the best
choice to ensure stability during administration and appropriate absorption. The application of -RESV and its derivatives
with anti-inflammatory and anticancer activity is presented with description of novel clinical trials.