Ligand Based-Pharmacophore Modeling and Extended Bi oactivity Prediction for Salinosporamide A, B and C from Marine Actino mycetes Salinispora tropica

2017 ◽  
Vol 20 (1) ◽  
pp. 3-19 ◽  
Author(s):  
Kesavan Dineshkumar ◽  
Aparna Vasudevan ◽  
Waheeta Hopper
Keyword(s):  
Pharmacophore Modeling ◽  
Salinosporamide A ◽  
Salinispora Tropica

Exploration and engineering of biosynthetic pathways in the marine actinomycete Salinispora tropica

2009 ◽  
Vol 81 (6) ◽  
pp. 1075-1084 ◽  
Author(s):  
Markus Nett ◽  
Bradley S. Moore
Keyword(s):  
Natural Products ◽  
Metabolic Pathways ◽  
Anticancer Agent ◽  
Complex Molecules ◽  
Dna Cleaving ◽  
Metabolic Plasticity ◽  
Salinosporamide A ◽  
Salinispora Tropica ◽  
Marine Actinomycete ◽  
Key Genes

In recent years, members of the marine actinomycete genus Salinispora have proven to be a precious source of structurally diverse secondary metabolites, including the potent anticancer agent salinosporamide A and the enediyne-derived sporolides. The tremendous potential of these marine-dwelling microbes for natural products biosynthesis, however, was not fully realized until sequencing of the Salinispora tropica genome revealed the presence of numerous orphan biosynthetic loci besides a plethora of rare metabolic pathways. This contribution summarizes the biochemical exploration of this prolific organism, highlighting studies in which genome-based information was exploited for the discovery of new enzymatic processes and the engineering of unnatural natural products. Inactivation of key genes within the salinosporamide pathway has expanded its inherent metabolic plasticity and enabled access to various salinosporamide derivatives by mutasynthesis. New insights into the biosynthesis of the sporolides allowed us to increase production titers of these structurally complex molecules, thereby providing the means to search for the DNA cleaving presporolide enediyne.

scholarly journals Coupled Biosynthesis of Volatiles and Salinosporamide A in Salinispora tropica

ChemBioChem ◽  
2016 ◽  
Vol 17 (20) ◽  
pp. 1978-1985 ◽  
Author(s):  
Ulrike Groenhagen ◽  
Ana Ligia Leandrini De Oliveira ◽  
Elisha Fielding ◽  
Bradley S. Moore ◽  
Stefan Schulz
Keyword(s):  
Salinosporamide A ◽  
Salinispora Tropica

scholarly journals Antileukemic Activity and Mechanism of Drug Resistance to the Marine Salinispora tropica Proteasome Inhibitor Salinosporamide A (Marizomib)

2014 ◽  
Vol 86 (1) ◽  
pp. 12-19 ◽  
Author(s):  
Denise Niewerth ◽  
Gerrit Jansen ◽  
Lesley F. V. Riethoff ◽  
Johan van Meerloo ◽  
Andrew J. Kale ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Proteasome Inhibitor ◽  
Antileukemic Activity ◽  
Salinosporamide A ◽  
Salinispora Tropica

Discovery of Novel NAMPT Inhibitors Based on Pharmacophore Modeling and Virtual Screening Techniques

2015 ◽  
Vol 17 (10) ◽  
pp. 868-878 ◽  
Author(s):  
Qianying Yi ◽  
Lu Zhou ◽  
Xin Shao ◽  
Taijin Wang ◽  
Guangkai Bao ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Pharmacophore Modeling ◽  
Screening Techniques

Validation of TZD Scaffold as Potential ARIs: Pharmacophore Modeling, Atom-based 3D QSAR and Docking Studies

2017 ◽  
Vol 20 (4) ◽  
Author(s):  
Lalita Dahiya ◽  
Manoj Kumar Mahapatra ◽  
Ramandeep Kaur ◽  
Vipin Kumar ◽  
Manoj Kumar
Keyword(s):  
3D Qsar ◽  
Pharmacophore Modeling ◽  
Docking Studies
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