Phosphorylation Processes Controlling Aromatase Activity in Br east Cancer: An Update

2016 ◽  
Vol 16 (9) ◽  
pp. 691-698 ◽  
Author(s):  
Stefania Catalano ◽  
Ines Barone ◽  
Stefania Marsico ◽  
Rosalinda Bruno ◽  
Sebastiano Andò
Keyword(s):  
Aromatase Activity

Rapid and Reversible Inhibition of Brain Aromatase Activity

2001 ◽  
Vol 13 (1) ◽  
pp. 63-73 ◽  
Author(s):  
J. Balthazart ◽  
M. Baillien ◽  
G. F. Ball
Keyword(s):  
Aromatase Activity ◽  
Reversible Inhibition ◽  
Brain Aromatase

scholarly journals Assessment of the Aromatase Inhibitory Activity of Ma-Huang-Tang (MHT) and Its Active Compounds

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Dong Ho Jung ◽  
Joo Tae Hwang ◽  
Bo-Jeong Pyun ◽  
Song Yi Yu ◽  
Byoung Seob Ko
Keyword(s):  
Herbal Medicines ◽  
Inhibitory Effect ◽  
Aromatase Activity ◽  
Cytochrome P450 Enzyme ◽  
Active Components ◽  
Glycyrrhizae Radix ◽  
Potent Inhibition ◽  
P450 Enzyme ◽  
Medicine Prescription ◽  
Ma Huang

Aromatase, a cytochrome P450 enzyme that converts androgens into estrogens, is an important drug target for hormone-dependent diseases. The purpose of this study was to elucidate the aromatase inhibitory effects of Ma-Huang-Tang (MHT), a traditional Korean herbal medicine prescription, and to identify its active ingredients. In this study, the inhibitory effect of MHT on aromatase activity was observed using dibenzylfluorescein (DBF) and KGN cells, and the dose-dependent effect of MHT was verified (IC50 values of 251 μg/mL and 246 μg/mL as determined by the two methods, respectively). Furthermore, among the six herbal medicines that constitute MHT, Ephedrae Herba, Cinnamomi Ramulus, and Glycyrrhizae Radix et Rhizoma showed the most potent inhibition of aromatase activity. Furthermore, upon identification of the active MHT compounds, three markers from Glycyrrhizae Radix et Rhizoma, liquiritin (5), liquiritin apioside (6), and liquiritigenin (7), were verified (IC50 values of 530 μM, 508 μM, and 1.611 mM and 499 μM, 522 μM, and 1.41 mM as determined by the two methods, respectively). In addition, their contents were confirmed to be 15.58, 19.80, and 2.22 mg/g, respectively, by HPLC/DAD analysis. These results indicate that the aromatase inhibitory effect of MHT results from the synergistic action of its active components and that MHT has potential as a preventive agent against aromatase activity.

Aromatase activity and interleukin-6 production by normal and malignant breast tissues.

1995 ◽  
Vol 80 (10) ◽  
pp. 3052-3058 ◽  
Author(s):  
A Purohit ◽  
M W Ghilchik ◽  
L Duncan ◽  
D Y Wang ◽  
A Singh ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Aromatase Activity ◽  
Malignant Breast ◽  
Breast Tissues

Influence of cell culture conditions on aromatase activity in human genital skin fibroblasts

1989 ◽  
Vol 25 (9) ◽  
pp. 806-812 ◽  
Author(s):  
Tarek Bisat ◽  
Terry R. Brown ◽  
Claude J. Migeon ◽  
Gary D. Berkovitz
Keyword(s):  
Cell Culture ◽  
Culture Conditions ◽  
Skin Fibroblasts ◽  
Aromatase Activity ◽  
Cell Culture Conditions

Aromatase activity of human granulosa cells in patients with polycystic ovaries treated with dexamethasone

1990 ◽  
Vol 54 (4) ◽  
pp. 597-600 ◽  
Author(s):  
David Bider ◽  
Clara Pariente ◽  
Jehoshua Dor ◽  
Mati Zolti ◽  
Shlomo Mashiach ◽  
...  
Keyword(s):  
Granulosa Cells ◽  
Aromatase Activity ◽  
Polycystic Ovaries ◽  
Human Granulosa Cells

Effects of Currently Used Pesticides in Assays for Estrogenicity, Androgenicity, and Aromatase Activity in Vitro

2002 ◽  
Vol 179 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Helle Raun Andersen ◽  
Anne Marie Vinggaard ◽  
Thomas Høj Rasmussen ◽  
Irene Marianne Gjermandsen ◽  
Eva Cecilie Bonefeld-Jørgensen
Keyword(s):  
Aromatase Activity

Demonstration of aromatase activity and its regulation in breast tumor and benign breast fibroblasts

1998 ◽  
Vol 49 (S1) ◽  
pp. S93-S99 ◽  
Author(s):  
R.J. Santen ◽  
J. Martel ◽  
M. Hoagland ◽  
F. Naftolin ◽  
L. Roa ◽  
...  
Keyword(s):  
Breast Tumor ◽  
Aromatase Activity ◽  
Breast Fibroblasts
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