A Review of 99mTc-labeled Tumor Metabolic Imaging Agents

2021 ◽  
Vol 21 ◽  
Author(s):  
Yilin Li ◽  
Junbo Zhang
Keyword(s):  
Nuclear Medicine ◽  
Amino Acid ◽  
Tumor Imaging ◽  
Low Cost ◽  
Metabolic Imaging ◽  
Imaging Agents ◽  
Amino Acid Derivatives ◽  
Nuclear Medicine Imaging ◽  
Convenient Preparation ◽  
Glucose Derivatives

: In recent years, with the development of nuclear medicine imaging technology, radionuclide-labeled tumor imaging agents have shown unique advantages in the early diagnosis of tumors. Due to the relatively low cost of SPECT in the clinic with the convenient preparation and suitable properties of 99mTc, 99mTc-labeled tumor metabolic imaging agents prepared based on principles of tumor metabolism have attracted considerable attention. This article briefly introduces the progress in the research of 99mTc-labeled glucose derivatives, amino acid derivatives, nucleotide derivatives and other tumor metabolic imaging agents and proposes the prospects for the development of 99mTc-labeled tumor metabolic imaging agents.

Patients with fever of unknown origin (FUO): diagnosis by nuclear medicine imaging

2001 ◽  
Vol 40 (03) ◽  
pp. 59-70 ◽  
Author(s):  
W. Becker ◽  
J. Meiler
Keyword(s):  
Nuclear Medicine ◽  
Fever Of Unknown Origin ◽  
Tumor Imaging ◽  
White Blood Cells ◽  
Unknown Origin ◽  
Final Diagnosis ◽  
Recurrent Fever ◽  
Nuclear Medicine Imaging

SummaryFever of unknown origin (FUO) in immunocompetent and non neutropenic patients is defined as recurrent fever of 38,3° C or greater, lasting 2-3 weeks or longer, and undiagnosed after 1 week of appropriate evaluation. The underlying diseases of FUO are numerous and infection accounts for only 20-40% of them. The majority of FUO-patients have autoimmunity and collagen vascular disease and neoplasm, which are responsible for about 50-60% of all cases. In this respect FOU in its classical definition is clearly separated from postoperative and neutropenic fever where inflammation and infection are more common. Although methods that use in-vitro or in-vivo labeled white blood cells (WBCs) have a high diagnostic accuracy in the detection and exclusion of granulocytic pathology, they are only of limited value in FUO-patients in establishing the final diagnosis due to the low prevalence of purulent processes in this collective. WBCs are more suited in evaluation of the focus in occult sepsis. Ga-67 citrate is the only commercially available gamma emitter which images acute, chronic, granulomatous and autoimmune inflammation and also various malignant diseases. Therefore Ga-67 citrate is currently considered to be the tracer of choice in the diagnostic work-up of FUO. The number of Ga-67-scans contributing to the final diagnosis was found to be higher outside Germany than it has been reported for labeled WBCs. F-l 8-2’-deoxy-2-fluoro-D-glucose (FDG) has been used extensively for tumor imaging with PET. Inflammatory processes accumulate the tracer by similar mechanisms. First results of FDG imaging demonstrated, that FDG may be superior to other nuclear medicine imaging modalities which may be explained by the preferable tracer kinetics of the small F-l 8-FDG molecule and by a better spatial resolution of coincidence imaging in comparison to a conventional gamma camera.

Synthesis and evaluation of macrocyclic amino acid derivatives for tumor imaging by gallium-68 positron emission tomography

2010 ◽  
Vol 18 (21) ◽  
pp. 7338-7347 ◽  
Author(s):  
Dinesh Shetty ◽  
Jae Min Jeong ◽  
Chang Hwan Ju ◽  
Young Ju Kim ◽  
Ji-Youn Lee ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Amino Acid ◽  
Tumor Imaging ◽  
Emission Tomography ◽  
Amino Acid Derivatives ◽  
Positron Emission ◽  
Gallium 68

Convenient preparation of amino acid derivatives with two 13C labels

1999 ◽  
Vol 40 (48) ◽  
pp. 8337-8341 ◽  
Author(s):  
Richard S. Fornicola ◽  
John Montgomery
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Convenient Preparation

A convenient synthesis of novel amino acid derivatives with potential antibacterial activity using sustainable materials

2017 ◽  
Vol 41 (5) ◽  
pp. 280-286
Author(s):  
Mohamed S. Behalo
Keyword(s):  
Antibacterial Activity ◽  
Amino Acid ◽  
Low Cost ◽  
Amino Acid Derivatives ◽  
Standard Drug ◽  
Chemical Structures ◽  
Coupling Reagent ◽  
Convenient Synthesis ◽  
Weak Activity ◽  
High Yields

Following the principles of green chemistry, cardanol derivatives have been used as renewable, low-cost and easily available natural starting materials to construct a variety of protected and unprotected amino acid derivatives. The reaction of cardanol derivatives with different phthalylamino acids including glycine, alanine, phenylalanine and valine in the presence of N,N′-dicyclohexylcarbodiimide (DCC) as coupling reagent yielded the target compounds in high yields. Deprotection of phthalylamino acid derivatives was achieved by heating with hydrazine hydrate. The chemical structures of all products were confirmed by spectral (FTIR, MS, 1H NMR, 13C NMR) and elemental analyses. The synthesised products were evaluated for their antibacterial activity, and the compounds exhibited potent to weak activity in comparison with a standard drug.

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