Directed Functional Connectivity of Posterior Cingulate Cortex and Whole Brain in Alzheimer's Disease and Mild Cognitive Impairment

2017 ◽  
Vol 14 (6) ◽  
pp. 628-635 ◽  
Author(s):  
Enyan Yu ◽  
Zhengluan Liao ◽  
Dewang Mao ◽  
Qi Zhang ◽  
Gongjun Ji ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Whole Brain ◽  
Posterior Cingulate

IC-P2-087: Posterior cingulate cortex atrophy and regional cingulum disruption in mild cognitive impairment and Alzheimer's disease

2008 ◽  
Vol 4 ◽  
pp. T42-T43 ◽  
Author(s):  
Il Han Choo ◽  
Dong Young Lee ◽  
Jungsu S. Oh ◽  
Jae Sung Lee ◽  
Dong Soo Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Posterior Cingulate

scholarly journals Analysis of the posterior cingulate cortex with [ 18 F]FDG-PET and Naa/mI in mild cognitive impairment and Alzheimer's disease: Correlations and differences between the two methods

2015 ◽  
Vol 9 (4) ◽  
pp. 385-393 ◽  
Author(s):  
Artur M.N. Coutinho ◽  
Fábio H.G. Porto ◽  
Poliana F. Zampieri ◽  
Maria C. Otaduy ◽  
Tíbor R. Perroco ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Fdg Pet ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Cognitively Normal ◽  
Posterior Cingulate ◽  
18F Fdg

ABSTRACT Reduction of regional brain glucose metabolism (rBGM) measured by [18F]FDG-PET in the posterior cingulate cortex (PCC) has been associated with a higher conversion rate from mild cognitive impairment (MCI) to Alzheimer's disease (AD). Magnetic Resonance Spectroscopy (MRS) is a potential biomarker that has disclosed Naa/mI reductions within the PCC in both MCI and AD. Studies investigating the relationships between the two modalities are scarce. OBJECTIVE To evaluate differences and possible correlations between the findings of rBGM and NAA/mI in the PCC of individuals with AD, MCI and of cognitively normal volunteers. METHODS Patients diagnosed with AD (N=32) or MCI (N=27) and cognitively normal older adults (CG, N=28), were submitted to [18F]FDG-PET and MRS to analyze the PCC. The two methods were compared and possible correlations between the modalities were investigated. RESULTS The AD group exhibited rBGM reduction in the PCC when compared to the CG but not in the MCI group. MRS revealed lower NAA/mI values in the AD group compared to the CG but not in the MCI group. A positive correlation between rBGM and NAA/mI in the PCC was found. NAA/mI reduction in the PCC differentiated AD patients from control subjects with an area under the ROC curve of 0.70, while [18F]FDG-PET yielded a value of 0.93. CONCLUSION rBGM and Naa/mI in the PCC were positively correlated in patients with MCI and AD. [18F]FDG-PET had greater accuracy than MRS for discriminating AD patients from controls.

Posterior cingulate cortex atrophy and regional cingulum disruption in mild cognitive impairment and Alzheimer's disease

2010 ◽  
Vol 31 (5) ◽  
pp. 772-779 ◽  
Author(s):  
IL Han Choo ◽  
Dong Young Lee ◽  
Jungsu S. Oh ◽  
Jae Sung Lee ◽  
Dong Soo Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Posterior Cingulate

scholarly journals Precuneus and Cingulate Cortex Atrophy and Hypometabolism in Patients with Alzheimer’s Disease and Mild Cognitive Impairment: MRI and18F-FDG PET Quantitative Analysis Using FreeSurfer

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Matthieu Bailly ◽  
Christophe Destrieux ◽  
Caroline Hommet ◽  
Karl Mondon ◽  
Jean-Philippe Cottier ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Regions Of Interest ◽  
Posterior Cingulate ◽  
Amnestic Mci ◽  
Prodromal Ad

Objective.The objective of this study was to compare glucose metabolism and atrophy, in the precuneus and cingulate cortex, in patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI), using FreeSurfer.Methods.47 individuals (17 patients with AD, 17 patients with amnestic MCI, and 13 healthy controls (HC)) were included. MRI and PET images using18F-FDG (mean injected dose of 185 MBq) were acquired and analyzed using FreeSurfer to define regions of interest in the hippocampus, amygdala, precuneus, and anterior and posterior cingulate cortex. Regional volumes were generated. PET images were registered to the T1-weighted MRI images and regional uptake normalized by cerebellum uptake (SUVr) was measured.Results.Mean posterior cingulate volume was reduced in MCI and AD. SUVr were different between the three groups: mean precuneus SUVr was 1.02 for AD, 1.09 for MCI, and 1.26 for controls (p<0.05); mean posterior cingulate SUVr was 0.96, 1.06, and 1.22 for AD, MCI, and controls, respectively (p<0.05).Conclusion.We found graduated hypometabolism in the posterior cingulate cortex and the precuneus in prodromal AD (MCI) and AD, whereas atrophy was not significant. This suggests that the use of18F-FDG in these two regions could be a neurodegenerative biomarker.

O3-09-01: Differential functional disruption, hypometabolism, and atrophy between ventral and dorsal posterior cingulate cortex networks in mild cognitive impairment and Alzheimer's disease

2015 ◽  
Vol 11 (7S_Part_5) ◽  
pp. P237-P237 ◽  
Author(s):  
Justine Mutlu ◽  
Robin de Flores ◽  
Clémence Tomadesso ◽  
Brigitte Landeau ◽  
Florence Mézenge ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Posterior Cingulate

scholarly journals P1-340: Posterior cingulate cortex atrophy and regional cingulum disruption in mild cognitive impairment and Alzheimer's disease

2008 ◽  
Vol 4 ◽  
pp. T318-T318
Author(s):  
Il Han Choo ◽  
Dong Young Lee ◽  
Jungsu S. Oh ◽  
Jae Sung Lee ◽  
Dong Soo Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Posterior Cingulate

Functional connectivity change between posterior cingulate cortex and ventral attention network relates to the impairment of orientation for time in Alzheimer’s disease patients

2018 ◽  
Vol 13 (1) ◽  
pp. 154-161 ◽  
Author(s):  
Ken-ichiro Yamashita ◽  
Taira Uehara ◽  
Pukovisa Prawiroharjo ◽  
Koji Yamashita ◽  
Osamu Togao ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Attention Network ◽  
Posterior Cingulate

Aberrant functional connectivity differentiates retrosplenial cortex from posterior cingulate cortex in prodromal Alzheimer's disease

2016 ◽  
Vol 44 ◽  
pp. 114-126 ◽  
Author(s):  
Kim N.H. Dillen ◽  
Heidi I.L. Jacobs ◽  
Juraj Kukolja ◽  
Boris von Reutern ◽  
Nils Richter ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Retrosplenial Cortex ◽  
Posterior Cingulate ◽  
Prodromal Alzheimer’S Disease
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