O5-03-01: Decreased resting-state functional connectivity of posterior cingulate cortex in amnestic MCI-to-Alzheimer's disease converters and non-converters

2013 ◽  
Vol 9 ◽  
pp. P832-P833
Author(s):  
Ying Han
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Resting State ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Resting State Functional Connectivity ◽  
Posterior Cingulate ◽  
Amnestic Mci

scholarly journals Neural basis underlying the trait of attachment anxiety and avoidance revealed by the amplitude of low-frequency fluctuations and resting-state functional connectivity

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Min Deng ◽  
Xing Zhang ◽  
Xiaoyan Bi ◽  
Chunhai Gao
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Low Frequency ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Attachment Anxiety ◽  
Frequency Fluctuation ◽  
Resting State Functional Connectivity ◽  
Attachment Avoidance ◽  
Posterior Cingulate

Abstract Background Attachment theory demonstrates that early attachment experience shapes internal working models with mental representations of self and close relationships, which affects personality traits and interpersonal relationships in adulthood. Although research has focused on brain structural and functional underpinnings to disentangle attachment styles in healthy individuals, little is known about the spontaneous brain activity associated with self-reported attachment anxiety and avoidance during the resting state. Methods One hundred and nineteen individuals participated in the study, completing the Experience in Close Relationship scale immediately after an 8-min fMRI scanning. We used the resting-state functional magnetic resonance imaging (rs-fMRI) signal of the amplitude of low-frequency fluctuation and resting-state functional connectivity to identify attachment-related regions and networks. Results Consequently, attachment anxiety is closely associated with the amplitude of low-frequency fluctuations in the right posterior cingulate cortex, over-estimating emotional intensity and exaggerating outcomes. Moreover, the functional connectivity between the posterior cingulate cortex and fusiform gyrus increases detection ability for potential threat or separation information, facilitating behavior motivation. The attachment avoidance is positively correlated with the amplitude of low-frequency fluctuation in the bilateral lingual gyrus and right postcentral and negatively correlated with the bilateral orbital frontal cortex and inferior temporal gyrus. Functional connection with attachment avoidance contains critical nodes in the medial temporal lobe memory system, frontal-parietal network, social cognition, and default mode network necessary to deactivate the attachment system and inhibit attachment-related behavior. Conclusion and implications These findings clarify the amplitude of low-frequency fluctuation and resting-state functional connectivity neural signature of attachment style, associated with attachment strategies in attachment anxiety and attachment avoidance individuals. These findings may improve our understanding of the pathophysiology of the attachment-related disorder.

scholarly journals Altered resting-state functional connectivity in emotion-processing brain regions in adults who were born very preterm

2016 ◽  
Vol 46 (14) ◽  
pp. 3025-3039 ◽  
Author(s):  
C. Papini ◽  
T. P. White ◽  
A. Montagna ◽  
P. J. Brittain ◽  
S. Froudist-Walsh ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Emotion Processing ◽  
Recognition Task ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Resting State Functional Connectivity ◽  
Dynamic Stimuli ◽  
Posterior Cingulate ◽  
Very Preterm

BackgroundVery preterm birth (VPT; <32 weeks of gestation) has been associated with impairments in emotion regulation, social competence and communicative skills. However, the neuroanatomical mechanisms underlying such impairments have not been systematically studied. Here we investigated the functional integrity of the amygdala connectivity network in relation to the ability to recognize emotions from facial expressions in VPT adults.MethodThirty-six VPT-born adults and 38 age-matched controls were scanned at rest in a 3-T MRI scanner. Resting-state functional connectivity (rs-fc) was assessed with SPM8. A seed-based analysis focusing on three amygdalar subregions (centro-medial/latero-basal/superficial) was performed. Participants’ ability to recognize emotions was assessed using dynamic stimuli of human faces expressing six emotions at different intensities with the Emotion Recognition Task (ERT).ResultsVPT individuals compared to controls showed reduced rs-fc between the superficial subregion of the left amygdala, and the right posterior cingulate cortex (p = 0.017) and the left precuneus (p = 0.002). The VPT group further showed elevated rs-fc between the left superficial amygdala and the superior temporal sulcus (p = 0.008). Performance on the ERT showed that the VPT group was less able than controls to recognize anger at low levels of intensity. Anger scores were significantly associated with rs-fc between the superficial amygdala and the posterior cingulate cortex in controls but not in VPT individuals.ConclusionsThese findings suggest that alterations in rs-fc between the amygdala, parietal and temporal cortices could represent the mechanism linking VPT birth and deficits in emotion processing.

scholarly journals Precuneus and Cingulate Cortex Atrophy and Hypometabolism in Patients with Alzheimer’s Disease and Mild Cognitive Impairment: MRI and18F-FDG PET Quantitative Analysis Using FreeSurfer

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Matthieu Bailly ◽  
Christophe Destrieux ◽  
Caroline Hommet ◽  
Karl Mondon ◽  
Jean-Philippe Cottier ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Regions Of Interest ◽  
Posterior Cingulate ◽  
Amnestic Mci ◽  
Prodromal Ad

Objective.The objective of this study was to compare glucose metabolism and atrophy, in the precuneus and cingulate cortex, in patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI), using FreeSurfer.Methods.47 individuals (17 patients with AD, 17 patients with amnestic MCI, and 13 healthy controls (HC)) were included. MRI and PET images using18F-FDG (mean injected dose of 185 MBq) were acquired and analyzed using FreeSurfer to define regions of interest in the hippocampus, amygdala, precuneus, and anterior and posterior cingulate cortex. Regional volumes were generated. PET images were registered to the T1-weighted MRI images and regional uptake normalized by cerebellum uptake (SUVr) was measured.Results.Mean posterior cingulate volume was reduced in MCI and AD. SUVr were different between the three groups: mean precuneus SUVr was 1.02 for AD, 1.09 for MCI, and 1.26 for controls (p<0.05); mean posterior cingulate SUVr was 0.96, 1.06, and 1.22 for AD, MCI, and controls, respectively (p<0.05).Conclusion.We found graduated hypometabolism in the posterior cingulate cortex and the precuneus in prodromal AD (MCI) and AD, whereas atrophy was not significant. This suggests that the use of18F-FDG in these two regions could be a neurodegenerative biomarker.

scholarly journals Functional connectivity between the entorhinal and posterior cingulate cortices associated with navigation impairment following path integration in at-genetic-risk Alzheimer’s disease

2019 ◽  
Author(s):  
Gillian Coughlan ◽  
Peter Zhukovsky ◽  
Vaisakh Puthusseryppady ◽  
Rachel Gillings ◽  
Anne-Marie Minihane ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Genetic Risk ◽  
Path Integration ◽  
Amyloid Plaque ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Classification Model ◽  
Posterior Cingulate

ABSTRACTNavigation processes mediated selectively by the entorhinal cortex (EC) may be impaired in individuals with suspected preclinical Alzheimer’s disease (AD), but the clinical utility of navigation tests to detect such impairments remains to be established. In a sample of 64 individuals (32 e3e3 and 32 e3e4), we tested whether an existing paradigm, the Virtual Supermarket Test (VST), can reliably detect the presence or absence of the APOE e4 allele which accelerates amyloid plaque deposition in the brain. The present study assessed four major navigational processes that are subserved by functionally specialised cell groups located in AD vulnerable regions including the EC and examined the relationship between navigation process and regional functional connectivity (FC) given FC is a marker early AD-related tau seeding. While heading direction and spatial memory were unaffected by at-risk AD, clear altered navigational strategies following path integration were found on the VST in the e3e4 group. The APOE-sensitive VST measure correctly classified 77% of the APOE cohort. Including resting-state FC between the EC and the posterior cingulate cortex, a correlate of the path integration deficit in the APOE e4 group, the classification model increased the accuracy to 85%. Our findings show that at-genetic-risk AD selectively impairs path integration and biases self-reported spatial locations away from the centre and towards the boundary of a virtual environment. Importantly, this impairment is associated with reduced FC between the EC and the posterior cingulate cortex, which in turn informs the neurobiological mechanisms of at-genetic-risk of AD.

Sign in / Sign up

Export Citation Format

Share Document