Inhibitors of Acyl-Coenzyme A: Cholesterol Acyltransferase

2005 ◽  
Vol 5 (6) ◽  
pp. 463-469 ◽  
Author(s):  
Akira Miyazaki ◽  
Tomoko Kanome ◽  
Takuya Watanabe
Keyword(s):  
Coenzyme A ◽  
Cholesterol Acyltransferase ◽  
Acyl Coenzyme A

Ontogeny of acyl-CoA: cholesterol acyltransferase in rat liver, intestine, and adipose tissue

1992 ◽  
Vol 262 (4) ◽  
pp. G599-G602
Author(s):  
M. T. Little ◽  
P. Hahn
Keyword(s):  
Adipose Tissue ◽  
Rat Liver ◽  
Animal Studies ◽  
Coenzyme A ◽  
Cholesterol Metabolism ◽  
Cholesterol Acyltransferase ◽  
Dietary Manipulation ◽  
Acat Activity ◽  
Brown Adipose ◽  
Acyl Coenzyme A

The development of acyl-coenzyme A: cholesterol acyltransferase (ACAT), was determined in the rat liver, intestine, and white (WAT) and brown adipose tissue (BAT). Animal studies have shown that dietary manipulation of cholesterol metabolism during an animal's early development can have persistent and permanent effects. Therefore it is important that the ontogeny of ACAT, one of the key enzymes in cholesterol metabolism, be clearly established. White Wistar rats were killed on day 21 of gestation, at birth, and on postnatal days 10, 14, 18, 21, 22, 25, 30, and 60. The tissues were rapidly excised, microsomes were prepared, and the activity of ACAT was measured as the rate of incorporation of [1-14C]oleoyl coenzyme A into cholesterol esters. Age-specific changes were observed in three of the four tissues investigated. Rat liver and intestine possess significant amounts of ACAT activity throughout development with marked variations in activity during this time. ACAT activity in BAT is low and variable throughout development with the exception of high activity noted in the adult animal. WAT contained little or no ACAT activity during development.

Localization of acyl-coenzyme A: Cholesterol acyltransferase-1 (ACAT-1) in macrophages and other various type cells of human tissues

2000 ◽  
Vol 151 (1) ◽  
pp. 292
Author(s):  
N. Sakashita ◽  
A. Miyazaki ◽  
M. Takeya ◽  
S. Horiuchi ◽  
C.C.Y. Chang ◽  
...  
Keyword(s):  
Coenzyme A ◽  
Cholesterol Acyltransferase ◽  
Human Tissues ◽  
Acyl Coenzyme A

scholarly journals Regulation of Rabbit Intestinal Acyl Coenzyme A-Cholesterol Acyltransferase In Vivo and In Vitro

1982 ◽  
Vol 83 (4) ◽  
pp. 873-880 ◽  
Author(s):  
F. Jeffrey Field ◽  
Allen D. Cooper ◽  
Sandra K. Erickson
Keyword(s):  
Coenzyme A ◽  
Cholesterol Acyltransferase ◽  
Acyl Coenzyme A
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