Mechanism of Action of Antitumor Drugs that Interact with Microtubules and Tubulin

2012 ◽  
Vol 2 (1) ◽  
pp. 1-17 ◽  
Author(s):  
M. Jordan
Keyword(s):  
Mechanism Of Action ◽  
Antitumor Drugs

Structure-based rationalization of antitumor drugs mechanism of action by a MIF approach

2004 ◽  
Vol 39 (3) ◽  
pp. 281-289 ◽  
Author(s):  
Gabriele Cruciani ◽  
Paolo Benedetti ◽  
Gianluigi Caltabiano ◽  
Daniele F Condorelli ◽  
Cosimo G Fortuna ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Antitumor Drugs

Pyrrolo[2,1-a]isoquinoline scaffold in drug discovery: advances in synthesis and medicinal chemistry

2019 ◽  
Vol 11 (20) ◽  
pp. 2735-2755 ◽  
Author(s):  
Maria D Matveeva ◽  
Rosa Purgatorio ◽  
Leonid G Voskressensky ◽  
Cosimo D Altomare
Keyword(s):  
Multidrug Resistance ◽  
Drug Discovery ◽  
Tumor Cells ◽  
Mechanism Of Action ◽  
Biological Activities ◽  
Antitumor Drugs ◽  
Antitumor Activities ◽  
Structure Activity ◽  
Synthetic Approaches ◽  
Potential Exploitation

Pyrrolo[2,1- a]isoquinoline (PIq) is a nitrogen heterocyclic scaffold of diverse alkaloids endowed with several biological activities, including antiretroviral and antitumor activities. Several 5,6-dihydro-PIq (DHPIq) alkaloids, belonging to the lamellarins’ family, have proved to be cytotoxic to tumor cells, as well as reversers of multidrug resistance. In this review, we provide an overview of the main achievements over the last decade in the synthetic approaches to access libraries of PIq compounds along with a survey, as comprehensive as possible, of bioactivity, mechanism of action, pharmacophore and structure–activity relationships of synthetic analogs of DHPIq-based alkaloids. The focus is mainly on the potential exploitation of the (DH)PIq scaffold in design and development of novel antitumor drugs.

scholarly journals Resorthiomycin, a novel antitumor antibiotic. III. Potentiation of antitumor drugs and its mechanism of action.

1990 ◽  
Vol 43 (2) ◽  
pp. 138-142 ◽  
Author(s):  
MAKOTO TAHARA ◽  
AKIHIRO TOMIDA ◽  
TOSHIO NISHIMURA ◽  
HIDEYO YAMAGUCHI ◽  
HIDEO SUZUKI
Keyword(s):  
Mechanism Of Action ◽  
Antitumor Drugs ◽  
Antitumor Antibiotic

Mindfulness as Mechanism of Action for Stress and Well-Being Improvements

2007 ◽  
Author(s):  
Shauna L. Shapiro ◽  
Doug Oman ◽  
Carl E. Thoresen ◽  
Thomas G. Plante ◽  
Tim Flinders
Keyword(s):  
Mechanism Of Action ◽  
Well Being

Anti-diabetic effect and mechanism of action of MaEsil (Prunus mume) extract

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
JT Hwang ◽  
HJ Yang ◽  
HJ Hur ◽  
JH Park
Keyword(s):  
Mechanism Of Action ◽  
Prunus Mume
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