The Medicinal Chemistry of Structure-based Inhibitor/Drug Design: Current Progress and Future Prospective

2021 ◽  
Vol 21 (13) ◽  
pp. 1097-1098
Author(s):  
Guo-Ping Zhou
Keyword(s):  
Drug Design ◽  
Medicinal Chemistry ◽  
Inhibitor Drug

Physics and Its Interfaces with Medicinal Chemistry and Drug Design

2013 ◽  
Vol 43 (4) ◽  
pp. 268-280 ◽  
Author(s):  
Ricardo N. Santos ◽  
Adriano D. Andricopulo
Keyword(s):  
Drug Design ◽  
Medicinal Chemistry

Using Computer-aided Drug Design and Medicinal Chemistry Strategies in the Fight Against Diabetes

2011 ◽  
Vol 28 (5) ◽  
pp. 787-796 ◽  
Author(s):  
Evandro P. Semighini ◽  
Jonathan A. Resende ◽  
Peterson de Andrade ◽  
Pedro A. B. Morais ◽  
Ivone Carvalho ◽  
...  
Keyword(s):  
Drug Design ◽  
Medicinal Chemistry ◽  
Computer Aided Drug Design ◽  
Computer Aided

Using Free Computational Resources To Illustrate the Drug Design Process in an Undergraduate Medicinal Chemistry Course

2015 ◽  
Vol 92 (5) ◽  
pp. 827-835 ◽  
Author(s):  
Ricardo P. Rodrigues ◽  
Saulo F. Andrade ◽  
Susimaire P. Mantoani ◽  
Vera L. Eifler-Lima ◽  
Vinicius B. Silva ◽  
...  
Keyword(s):  
Drug Design ◽  
Design Process ◽  
Medicinal Chemistry ◽  
Computational Resources

scholarly journals Synthesis of Novel Schiff Base Derivates Containing a Fragment of the HIV Integrase Inhibitor Drug Raltegravir

Proceedings ◽  
2019 ◽  
Vol 41 (1) ◽  
pp. 5
Author(s):  
Jairo J. Rojas-Ortiz ◽  
Claudia Contreras-Celedón ◽  
Mario A. Gómez-Hurtado ◽  
Luis Chacón-García ◽  
Carlos J. Cortes-García
Keyword(s):  
Schiff Base ◽  
Medicinal Chemistry ◽  
Nitrogen Heterocycles ◽  
Integrase Inhibitor ◽  
Hiv Integrase ◽  
First Report ◽  
Biological Relevance ◽  
Inhibitor Drug

An eco-friendly methodology for the synthesis of novel Schiff base analogs of Raltegravir, an Integrase inhibitor drug is described. Pertinence of these imine derivatives is related to Medicinal Chemistry to develop new anti-VIH compounds. To our knowledge, this is the first report of the synthesis of Schiff base using a Raltegravir drug fragment as amino component. In addition, these Imines will be used as a synthetic precursor to prepare other nitrogen heterocycles of biological relevance such as 1,5-disubstituted Tetrazoles.

Recent Insights on the Medicinal Chemistry of Metal-Based Compounds: Hints for the Successful Drug Design

2010 ◽  
Vol 17 (31) ◽  
pp. 3739-3750 ◽  
Author(s):  
M. Z. Hernandes ◽  
F. J.de S. Pontes ◽  
L. C.D. Coelho ◽  
D. R.M. Moreira ◽  
V. R.A. Pereira ◽  
...  
Keyword(s):  
Drug Design ◽  
Medicinal Chemistry

Computer-Assisted Drug Design (CADD) The definition also appears in the Glossary of Terms used in Medicinal Chemistry.

2016 ◽  
Author(s):  
H. Van De Waterbeemd ◽  
R. E. Carter ◽  
G. Grassy ◽  
H. Kubinyi ◽  
Y. C. Martin ◽  
...  
Keyword(s):  
Drug Design ◽  
Medicinal Chemistry ◽  
Computer Assisted
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