Novel Peptide Mimetics Based on N-protected Amino Acids Derived from Isomannide as Potential Inhibitors of NS3 Serine Protease of Hepatitis C Virus

2012 ◽  
Vol 9 (4) ◽  
pp. 239-249 ◽  
Author(s):  
Thalita G. Barros ◽  
Bruna C. Zorzanelli ◽  
Sergio Pinheiro ◽  
Monique A. de Brito ◽  
Amilcar Tanuri ◽  
...  
Keyword(s):  
Amino Acids ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Serine Protease ◽  
Peptide Mimetics ◽  
Potential Inhibitors

NS3 is a serine protease required for processing of hepatitis C virus polyprotein.

1993 ◽  
Vol 67 (7) ◽  
pp. 4017-4026 ◽  
Author(s):  
L Tomei ◽  
C Failla ◽  
E Santolini ◽  
R De Francesco ◽  
N La Monica
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Serine Protease ◽  
Virus Polyprotein

Discovery and structural diversity of the hepatitis C virus NS3/4A serine protease inhibitor series leading to clinical candidate IDX320

2015 ◽  
Vol 25 (22) ◽  
pp. 5427-5436 ◽  
Author(s):  
Christophe C. Parsy ◽  
François-René Alexandre ◽  
Valérie Bidau ◽  
Florence Bonnaterre ◽  
Guillaume Brandt ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Protease Inhibitor ◽  
Serine Protease ◽  
Structural Diversity ◽  
Serine Protease Inhibitor ◽  
Clinical Candidate

Structure-based design of inhibitors of NS3 serine protease of hepatitis C virus

2004 ◽  
Vol 22 (3) ◽  
pp. 209-220 ◽  
Author(s):  
Vladimı́r Frecer ◽  
Martin Kabeláč ◽  
Piergiuseppe De Nardi ◽  
Sabrina Pricl ◽  
Stanislav Miertuš
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Serine Protease

scholarly journals Branched‐chain amino acids reduce hepatic iron accumulation and oxidative stress in hepatitis C virus polyprotein‐expressing mice

2014 ◽  
Vol 35 (4) ◽  
pp. 1303-1314 ◽  
Author(s):  
Masaaki Korenaga ◽  
Sohji Nishina ◽  
Keiko Korenaga ◽  
Yasuyuki Tomiyama ◽  
Naoko Yoshioka ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Amino Acids ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Branched Chain Amino Acids ◽  
Iron Accumulation ◽  
Hepatic Iron ◽  
Branched Chain ◽  
Virus Polyprotein ◽  
And Oxidative Stress

Syntheses of nucleosides with 2′-spirolactam and 2′-spiropyrrolidine moieties as potential inhibitors of hepatitis C virus NS5B polymerase

2014 ◽  
Vol 55 (28) ◽  
pp. 3813-3816 ◽  
Author(s):  
Qun Dang ◽  
Zhibo Zhang ◽  
Bingyu Tang ◽  
Yang Song ◽  
Ling Wu ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Potential Inhibitors ◽  
Ns5b Polymerase
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