Synthesis and Bioevaluation of Shikonin Derivatives

2018 ◽  
Vol 15 (9) ◽  
pp. 945-950
Author(s):  
Sufen Cao ◽  
Jiangang Zhang ◽  
Wenhu Duan
Keyword(s):  
Shikonin Derivatives

Shikonin derivatives from the roots of Onosma nigricaule (Boraginaceae)

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
U Özgen ◽  
G Bulut ◽  
C Kazaz ◽  
H Seçen
Keyword(s):  
Shikonin Derivatives

The shikonin derivatives and pyrrolizidine alkaloids in hairy root cultures of Lithospermum canescens (Michx.) Lehm.

2006 ◽  
Vol 25 (10) ◽  
pp. 1052-1058 ◽  
Author(s):  
A. Pietrosiuk ◽  
K. Sykłowska-Baranek ◽  
H. Wiedenfeld ◽  
R. Wolinowska ◽  
M. Furmanowa ◽  
...  
Keyword(s):  
Hairy Root ◽  
Pyrrolizidine Alkaloids ◽  
Hairy Root Cultures ◽  
Root Cultures ◽  
Shikonin Derivatives ◽  
Lithospermum Canescens

The effects of CA2+ during the elicitation of shikonin derivatives inOnosma paniculatum cells

1998 ◽  
Vol 34 (3) ◽  
pp. 261-265 ◽  
Author(s):  
Wen Ning ◽  
Jin-Xi Wang ◽  
Yong-Ming Liu ◽  
Ning Li ◽  
Ri-Qiang Cao
Keyword(s):  
Shikonin Derivatives

Production of shikonin derivatives by cell suspension cultures of Lithospermum erythrorhizon

1987 ◽  
Vol 6 (3) ◽  
pp. 197-199 ◽  
Author(s):  
Hiroshi Deno ◽  
Chuzo Suga ◽  
Teijiro Morimoto ◽  
Yasuhiro Fujita
Keyword(s):  
Cell Suspension ◽  
Cell Suspension Cultures ◽  
Suspension Cultures ◽  
Lithospermum Erythrorhizon ◽  
Shikonin Derivatives

scholarly journals Inhibition on platelet activation by shikonin derivatives isolated from Arnebia euchroma

1995 ◽  
Vol 1268 (3) ◽  
pp. 329-334 ◽  
Author(s):  
Feng-Nien Ko ◽  
Yi-San Lee ◽  
Sheng-Chu Kuo ◽  
Yuan-Shium Chang ◽  
Che-Ming Teng
Keyword(s):  
Platelet Activation ◽  
Arnebia Euchroma ◽  
Shikonin Derivatives

scholarly journals Anti-tumor effects of shikonin derivatives on human medullary thyroid carcinoma cells

2017 ◽  
Vol 6 (2) ◽  
pp. 53-62 ◽  
Author(s):  
Carina Hasenoehrl ◽  
Gert Schwach ◽  
Nassim Ghaffari-Tabrizi-Wizsy ◽  
Robert Fuchs ◽  
Nadine Kretschmer ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Thyroid Carcinoma ◽  
Cell Viability ◽  
Medullary Thyroid Carcinoma ◽  
Petroleum Ether Extract ◽  
Migration And Invasion ◽  
Normal Human Skin ◽  
Medullary Thyroid ◽  
Shikonin Derivatives

New treatment options are needed for medullary thyroid carcinoma (MTC), a highly metastasizing neuroendocrine tumor that is resistant to standard radiotherapy and chemotherapy. We show that the following shikonin derivatives inhibit cell proliferation and cell viability of the MTC cell line TT: acetylshikonin, β,β-dimethylacrylshikonin, shikonin and a petroleum ether extract of the roots of Onosma paniculata containing several shikonin derivatives. The unsubstituted shikonin derivative was found to be the most effective compound with an IC50 of 1.1 µM. The cell viability of normal human skin fibroblasts, however, was not affected by the tested substances, indicating that shikonin derivatives might be selectively toxic for cancer cells. We further report that migration and invasion of TT cells were inhibited at non-toxic concentrations. Finally, shikonin was tested in vivo using the chick chorioallantoic membrane assay, where it significantly reduced tumor growth by inhibiting cell proliferation and inducing apoptosis. In summary, our results suggest that shikonin derivatives have the potential for the treatment of medullary thyroid carcinomas.

Shikonin Derivatives. V. Chemical Investigations ofArnebia decumbens

1986 ◽  
Vol 50 (3) ◽  
pp. 759-760
Author(s):  
Mohammad Afzal ◽  
Galib Al-Oriqat
Keyword(s):  
Shikonin Derivatives
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