Comparison of Bone Uptake in Bone Scan and Ga-68 PSMA PET/CT Images in Patients with Prostate Cancer

2019 ◽  
Vol 15 (6) ◽  
pp. 589-594
Author(s):  
Emine Acar ◽  
Recep Bekiş ◽  
Berna Polack
Keyword(s):  
Prostate Cancer ◽  
Bone Metastases ◽  
Bone Scintigraphy ◽  
Bone Scan ◽  
Ct Images ◽  
Additional Contribution ◽  
Psma Pet ◽  
Pet Ct ◽  
Increased Activity ◽  
Psma Expression

Objective: The aim of this study was to compare images from Tc-99m MDP bone scan (BS) and Ga-68 PSMA PET/CT of patients with prostate cancer in terms of bone metastases. Methods: Overall, 34 patients exhibited a mean age of 66 ± 9.5 (50-88) years, mean PSA of 51 ± 159ng/ml (0-912), and mean Gleason score of 8 (6-9). BS and Ga-68 PSMA PET/CT were applied to 34 patients within 30 days, and the results were evaluated, retrospectively. In both tests, radiopharmaceutical uptake in bones were compared. Results: In 7 patients (20.5%), uptake was not significant on BS and Ga-68 PSMA PET / CT images, which is related to metastasis. In 14 (41%) patients, bone metastases were observed in both examinations. However, more metastatic lesions were observed in the Ga-68 PSMA PET/CT of 3 patients and in the bone scintigraphy of 2 patients. PSMA expression was not observed on Ga-68 PSMA PET / CT in 13 (38%) patients with increased activity in bone scintigraphy. Two (6%) of these patients were thought to be metastatic, 2 (6%) were suspicious for metastasis, and 9 (26%) had no metastasis. When a lesion-based evaluation was performed, a total of 480 activities were evaluated: increased activity uptake was found in 305 BS, and 427 PSMA expression activity was detected. Furthermore, 435 of these activities were evaluated as metastatic. Conclusion: Ga-68 PSMA PET/CT provides an additional contribution to the BS evaluation of activity areas because of the presence of PSMA expression and anatomical lesions. In 6% of the patients, activity on BS and metastatic appearance in CT images were observed and the presence of lesions in the absence of PSMA was determined. This suggests that bone metastases without PSMA expression may also be present.

Diffuse bone metastases on 68Ga-PSMA PET-CT in a patient with prostate cancer and normal bone scan

2016 ◽  
Vol 43 (8) ◽  
pp. 1563-1564 ◽  
Author(s):  
J. Lavalaye ◽  
P. Kaldeway ◽  
H. H. E. van Melick
Keyword(s):  
Prostate Cancer ◽  
Bone Metastases ◽  
Bone Scan ◽  
Normal Bone ◽  
Psma Pet ◽  
Pet Ct

scholarly journals Machine learning for differentiating metastatic and completely responded sclerotic bone lesion in prostate cancer: a retrospective radiomics study

2019 ◽  
Vol 92 (1101) ◽  
pp. 20190286 ◽  
Author(s):  
Emine Acar ◽  
Asım Leblebici ◽  
Berat Ender Ellidokuz ◽  
Yasemin Başbınar ◽  
Gamze Çapa Kaya
Keyword(s):  
Prostate Cancer ◽  
Machine Learning ◽  
Texture Analysis ◽  
Area Under The Curve ◽  
Ct Images ◽  
Metastatic Lesions ◽  
Psma Pet ◽  
Pet Ct ◽  
Sclerotic Lesions ◽  
Psma Expression

Objective:Using CT texture analysis and machine learning methods, this study aims to distinguish the lesions imaged via 68Ga-prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/CT as metastatic and completely responded in patients with known bone metastasis and who were previously treated.Methods:We retrospectively reviewed the 68Ga-PSMA PET/CT images of 75 patients after treatment, who were previously diagnosed with prostate cancer and had known bone metastasis. A texture analysis was performed on the metastatic lesions showing PSMA expression and completely responded sclerotic lesions without PSMA expression through CT images. Textural features were compared in two groups. Thus, the distinction of metastasis/completely responded lesions and the most effective parameters in this issue were determined by using various methods [decision tree, discriminant analysis, support vector machine (SVM), k-nearest neighbor (KNN), ensemble classifier] in machine learning.Results:In 28 of the 35 texture analysis findings, there was a statistically significant difference between the two groups. The Weighted KNN method had the highest accuracy and area under the curve, has been chosen as the best model. The weighted KNN algorithm was succeeded to differentiate sclerotic lesion from metastasis or completely responded lesions with 0.76 area under the curve. GLZLM_SZHGE and histogram-based kurtosis were found to be the most important parameters in differentiating metastatic and completely responded sclerotic lesions.Conclusions:Metastatic lesions and completely responded sclerosis areas in CT images, as determined by 68Ga-PSMA PET, could be distinguished with good accuracy using texture analysis and machine learning (Weighted KNN algorithm) in prostate cancer.Advances in knowledge:Our findings suggest that, with the use of newly emerging software, CT imaging can contribute to identifying the metastatic lesions in prostate cancer.

scholarly journals Added value of 68Ga-PSMA PET/CT for the detection of bone metastases in patients with newly diagnosed prostate cancer and a previous 99mTc bone scintigraphy

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Helle D. Zacho ◽  
Søren Ravn ◽  
Ali Afshar-Oromieh ◽  
Joan Fledelius ◽  
June A. Ejlersen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Metastases ◽  
Bone Scintigraphy ◽  
Added Value ◽  
Newly Diagnosed ◽  
Psma Pet ◽  
Pet Ct

scholarly journals Assessment of Bone Metastases in Patients with Prostate Cancer—A Comparison between 99mTc-Bone-Scintigraphy and [68Ga]Ga-PSMA PET/CT

2017 ◽  
Vol 10 (4) ◽  
pp. 68 ◽  
Author(s):  
Lena Thomas ◽  
Caroline Balmus ◽  
Hojjat Ahmadzadehfar ◽  
Markus Essler ◽  
Holger Strunk ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Metastases ◽  
Bone Scintigraphy ◽  
Psma Pet ◽  
Pet Ct

Bone scintigraphy as a gatekeeper for the detection of bone metastases in patients with prostate cancer: comparison with Ga-68 PSMA PET/CT

2020 ◽  
Vol 34 (12) ◽  
pp. 932-941
Author(s):  
Meltem Caglar ◽  
Murat Tuncel ◽  
Egemen Yildiz ◽  
Erdem Karabulut
Keyword(s):  
Prostate Cancer ◽  
Bone Metastases ◽  
Bone Scintigraphy ◽  
Psma Pet ◽  
Pet Ct

Comparison of PSMA-PET/CT, choline-PET/CT, NaF-PET/CT, MRI, and bone scintigraphy in the diagnosis of bone metastases in patients with prostate cancer: a systematic review and meta-analysis

2019 ◽  
Vol 48 (12) ◽  
pp. 1915-1924 ◽  
Author(s):  
Jing Zhou ◽  
Zhengxing Gou ◽  
Renhui Wu ◽  
Yuan Yuan ◽  
Guiquan Yu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Systematic Review ◽  
Bone Metastases ◽  
Bone Scintigraphy ◽  
Meta Analysis ◽  
Choline Pet ◽  
Psma Pet ◽  
Pet Ct

scholarly journals Nuclear Imaging for Bone Metastases in Prostate Cancer: The Emergence of Modern Techniques Using Novel Radiotracers

Diagnostics ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 117
Author(s):  
Wietske I. Luining ◽  
Dennie Meijer ◽  
Max R. Dahele ◽  
André N. Vis ◽  
Daniela E. Oprea-Lager
Keyword(s):  
Prostate Cancer ◽  
Computed Tomography ◽  
Bone Metastases ◽  
Bone Scintigraphy ◽  
Nuclear Imaging ◽  
Prostate Specific Membrane Antigen ◽  
Conventional Imaging ◽  
Psma Pet ◽  
Pet Ct ◽  
Specific Membrane

Accurate staging of prostate cancer (PCa) at initial diagnosis and at biochemical recurrence is important to determine prognosis and the optimal treatment strategy. To date, treatment of metastatic PCa has mostly been based on the results of conventional imaging with abdominopelvic computed tomography (CT) and bone scintigraphy. However, these investigations have limited sensitivity and specificity which impairs their ability to accurately identify and quantify the true extent of active disease. Modern imaging modalities, such as those based on the detection of radioactively labeled tracers with combined positron emission tomography/computed tomography (PET/CT) scanning have been developed specifically for the detection of PCa. Novel radiotracers include 18F-sodium fluoride (NaF), 11C-/18F-fluorocholine (FCH), 18F-fluordihydrotestosterone (FDHT), 68Gallium and 18F-radiolabeled prostate-specific membrane antigen (e.g., 68Ga-PSMA-11, 18F-DCFPyL). PET/CT with these tracers outperforms conventional imaging. As a result of this, although their impact on outcome needs to be better defined in appropriate clinical trials, techniques like prostate-specific membrane antigen (PSMA) PET/CT have been rapidly adopted into clinical practice for (re)staging PCa. This review focuses on nuclear imaging for PCa bone metastases, summarizing the literature on conventional imaging (focusing on CT and bone scintigraphy—magnetic resonance imaging is not addressed in this review), highlighting the prognostic importance of high and low volume metastatic disease which serves as a driver for the development of better imaging techniques, and finally discussing modern nuclear imaging with novel radiotracers.

scholarly journals Prospective comparative study of 18F-sodium fluoride PET/CT and planar bone scintigraphy for treatment response assessment of bone metastases in patients with prostate cancer

2018 ◽  
Vol 57 (8) ◽  
pp. 1063-1069 ◽  
Author(s):  
Randi Fuglsang Fonager ◽  
Helle Damgaard Zacho ◽  
Niels Christian Langkilde ◽  
Joan Fledelius ◽  
June Anita Ejlersen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Comparative Study ◽  
Bone Metastases ◽  
Treatment Response ◽  
Bone Scintigraphy ◽  
Sodium Fluoride ◽  
Response Assessment ◽  
Pet Ct ◽  
Prospective Comparative Study ◽  
Treatment Response Assessment
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