A Computational Study of Three Frequent Mutations of EGFR and their Effects on Protein Dimer Formation and Non-Small Cell Lung Cancer Drug Resistance

2016 ◽  
Vol 11 (3) ◽  
pp. 382-391
Author(s):  
Zhiyong Shen ◽  
Debby D. Wang ◽  
Lichun Ma ◽  
Hong Yan ◽  
Maria P. Wong ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Computational Study ◽  
Small Cell ◽  
Cancer Drug ◽  
Small Cell Lung ◽  
Dimer Formation ◽  
Cancer Drug Resistance ◽  
Protein Dimer ◽  
Frequent Mutations

scholarly journals Computational methods for the analysis and prediction of drug resistance in EGFR-mutated non-small cell lung cancer patients

2021 ◽  
Author(s):  
Rizwan Qureshi
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Computational Methods ◽  
Review Paper ◽  
Small Cell ◽  
Cancer Drug ◽  
Small Cell Lung ◽  
Lung Cancer Patients ◽  
Cancer Drug Resistance ◽  
Egfr Mutated

This is a review paper for the analysis and prediction of lung cancer drug resistance. We explore several computational methods, that can provide, biological insights for the analysis, visualization and prediction of lung cancer drug resistance.

scholarly journals Computational methods for the analysis and prediction of drug resistance in EGFR-mutated non-small cell lung cancer patients

2021 ◽  
Author(s):  
Rizwan Qureshi
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Computational Methods ◽  
Review Paper ◽  
Small Cell ◽  
Cancer Drug ◽  
Small Cell Lung ◽  
Lung Cancer Patients ◽  
Cancer Drug Resistance ◽  
Egfr Mutated

This is a review paper for the analysis and prediction of lung cancer drug resistance. We explore several computational methods, that can provide, biological insights for the analysis, visualization and prediction of lung cancer drug resistance.

Integrated clinical and basic studies related to circumventing non-small cell lung cancer drug resistance

Lung Cancer ◽  
1994 ◽  
Vol 10 ◽  
pp. S73-S81 ◽  
Author(s):  
James L. Mulshine ◽  
Bruce E. Johnson ◽  
Adi F. Gazdar ◽  
Gail L. Shaw ◽  
Barnett S. Kramer ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Cancer Drug ◽  
Small Cell Lung ◽  
Cancer Drug Resistance ◽  
Basic Studies

circSNX6 (hsa_circ_0031608) enhances drug resistance of non-small cell lung cancer (NSCLC) via miR-137

2021 ◽  
Vol 567 ◽  
pp. 79-85
Author(s):  
Koujun Zhu ◽  
Jun Zhu ◽  
Jichun Geng ◽  
Yongjian Zhang ◽  
Yan Qin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals Expression Profiles of microRNAs in Drug-Resistant Non-Small Cell Lung Cancer Cell Lines Using microRNA Sequencing

2018 ◽  
Vol 51 (6) ◽  
pp. 2509-2522 ◽  
Author(s):  
Shousen Hu ◽  
Yongliang Yuan ◽  
Zhizhen Song ◽  
Dan Yan ◽  
Xiangzhen Kong
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Small Cell Lung Cancer ◽  
Cell Lines ◽  
Cell Lung Cancer ◽  
Expression Profiles ◽  
Small Cell ◽  
Nsclc Cell ◽  
Drug Resistant ◽  
Small Cell Lung

Background/Aims: Drug resistance remains a main obstacle to the treatment of non- small cell lung cancer (NSCLC). The aim of this study was to identify the expression profiles of microRNAs (miRNAs) in drug-resistant NSCLC cell lines. Methods: The expression profiles of miRNAs in drug-resistant NSCLC cell lines were examined using miRNA sequencing, and the common dysregulated miRNAs in these cell lines were identified and analyzed by bioinformatics methods. Results: A total of 29 upregulated miRNAs and 36 downregulated miRNAs were found in the drug-resistant NSCLC cell lines, of which 26 upregulated and 36 downregulated miRNAs were found to be involved in the Ras signaling pathway. The expression levels, survival analysis, and receiver operating characteristic curve of the dysregulated miRNAs based on The Cancer Genome Atlas database for lung adenocarcinoma showed that hsa-mir-192, hsa-mir-1293, hsa-mir-194, hsa-mir-561, hsa-mir-205, hsa-mir-30a, and hsa-mir-30c were related to lung cancer, whereas only hsa-mir-1293 and hsa-mir-561 were not involved in drug resistance. Conclusion: The results of this study may provide novel biomarkers for drug resistance in NSCLC and potential therapies for overcoming drug resistance, and may also reveal the potential mechanisms underlying drug resistance in this disease.

scholarly journals Small cell lung cancer transformation during antitumor therapies: A systematic review

Open Medicine ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 1160-1167
Author(s):  
Xing Chai ◽  
Xinru Zhang ◽  
Wenqian Li ◽  
Jin Chai
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Treatment Strategies ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancers ◽  
Histological Transformation ◽  
Nsclc Patients

Abstract Lung cancer is the most common cause of cancer-related death. Non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) are the two major histological categories of lung cancers. Drug resistance is a great challenge for cancer treatment, and histological transformation from NSCLC to SCLC is one of the mechanisms underlying drug resistance in NSCLC patients. SCLC-transformed patients show combined characteristics of NSCLC and SCLC; however, they lack timely diagnoses and effective treatment strategies. Thus, we reviewed the clinical characteristics of SCLC transformation patients with a literature search to enhance clinical consciousness, diagnosis, and personalized treatment for patients with it.

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