Can Colorectal Cancer be Prevented or Treated by Oral Hormone Replacement Therapy?

2009 ◽  
Vol 2 (3) ◽  
pp. 285-292
Author(s):  
P. Li ◽  
J. Lin ◽  
S. Schulz ◽  
G. Pitari ◽  
S. Waldman
Keyword(s):  
Colorectal Cancer ◽  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Hormone Replacement

scholarly journals Hormone replacement therapy, body mass, and the risk of colorectal cancer among postmenopausal women from Germany

2007 ◽  
Vol 97 (11) ◽  
pp. 1486-1492 ◽  
Author(s):  
M Hoffmeister ◽  
E Raum ◽  
J Winter ◽  
J Chang-Claude ◽  
H Brenner
Keyword(s):  
Colorectal Cancer ◽  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Hormone Replacement

The effect of opposed versus unopposed hormone replacement therapy (HRT) on the risk of colorectal cancer (CRC).

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. 3619-3619
Author(s):  
K. Lin ◽  
W. Y. Cheung ◽  
J. Y. Lai ◽  
E. L. Giovannucci
Keyword(s):  
Colorectal Cancer ◽  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Hormone Replacement

Hormone replacement therapy and the risk of colorectal cancer: a meta-analysis

1998 ◽  
Vol 5 (4) ◽  
pp. 165
Author(s):  
Kavita Nanda ◽  
Lori A. Bastian ◽  
Victor Hasselblad ◽  
David L. Simel
Keyword(s):  
Colorectal Cancer ◽  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Meta Analysis ◽  
Hormone Replacement

The Hormone Replacement Therapy of Risk and Survival in Colorectal Cancer: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Kefeng Liu ◽  
Yaodong Song ◽  
Xianzhuo Zhang ◽  
Yongjie Yang ◽  
Kunfeng Du ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Meta Analysis ◽  
Hormone Replacement

scholarly journals Oral contraceptives, hormone replacement therapy and the risk of colorectal cancer

1996 ◽  
Vol 73 (11) ◽  
pp. 1431-1435 ◽  
Author(s):  
E Fernandez ◽  
C La Vecchia ◽  
B D'Avanzo ◽  
S Franceschi ◽  
E Negri ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Oral Contraceptives ◽  
Hormone Replacement

scholarly journals Association of hormone replacement therapy with mortality in colorectal cancer survivor: a systematic review and meta-analysis

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Yeu-Chai Jang ◽  
Hsi-Lan Huang ◽  
Chi Yan Leung
Keyword(s):  
Colorectal Cancer ◽  
Hormone Replacement Therapy ◽  
Cancer Survivors ◽  
Replacement Therapy ◽  
Meta Analysis ◽  
Hormone Replacement ◽  
Colorectal Cancer Survivors ◽  
Specific Mortality ◽  
Cancer Specific Mortality ◽  
Overall Mortality

Abstract Background Hormone replacement therapy (HRT) use has shown to be associated with a reduced risk of colorectal cancer, however, its impact on survival among women with colorectal cancer remains uncertain. This meta-analysis aimed to systematically assess the survival benefit of HRT use in patients with colorectal cancer. Methods PRISMA guidelines for the reporting of meta-analyses were followed. We systematically searched PubMed, Embase, Cochrane library, Scopus, and PsycINFO from inception to 12 January 2019, with no language restrictions, for randomized controlled trials and cohort studies reporting the association between hormone replacement therapy and risk of colorectal cancer mortality or all-cause mortality in colorectal cancer survivors. We used the Newcastle-Ottawa Scale to assess the risk of bias of the included studies. We summarized the association as hazard ratio (HR; 95% CI) using random-effects meta-analysis. The study protocol was registered in PROSPERO (CRD42017071914). Results Of 1648 articles identified, five cohorts including 10,013 colorectal cancer survivors were included in this meta-analysis. Compared with women with no prior use of HRT, those reporting current use of HRT had lower risks of colorectal cancer-specific mortality (HR, 0.71 [95% CI, 0.62–0.80], I2 = 0%) and overall mortality (HR, 0.74 [95% CI, 0.67–0.81], I2 = 0%). Low between-study variance was also suggested by the narrow prediction interval for colorectal cancer-specific mortality (0.58–0.86) and overall mortality (0.63–0.87), which indicated that a future study will show survival benefits in women with current HRT use compared with those with no HRT exposure. Inverse associations with colorectal cancer-specific (HR, 1.02 [95% CI, 0.82–1.28], I2 = 0%) and overall mortality (HR, 1.07 [95% CI, 0.90–1.27], I2 = 0%) were not observed for former users of HRT. Sensitivity analyses revealed no differences in the risk estimates between two groups. Conclusions The findings suggest that the current use of HRT is associated with lower risks of colorectal cancer-specific and overall mortality in patients with colorectal cancer. Further investigations to elucidate the underlying mechanism are warranted.

Sign in / Sign up

Export Citation Format

Share Document