Preparation, Characterization and In-Vivo Evaluation of Raloxifene Hydrochloride Solid Lipid Nanoparticles

2012 ◽  
Vol 1 (1) ◽  
pp. 68-77 ◽  
Author(s):  
Vijaykumar Nekkanti ◽  
Vobalaboina Venkateshwarlu ◽  
Raviraj Pillai
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
In Vivo Evaluation ◽  
Solid Lipid ◽  
Raloxifene Hydrochloride

Solid Lipid Nanoparticles (SLNs) Gels for Topical Delivery of Aceclofenac in vitro and in vivo Evaluation

2013 ◽  
Vol 10 (6) ◽  
pp. 656-666 ◽  
Author(s):  
Sandipan Dasgupta ◽  
Surajit Ghosh ◽  
Subhabrata Ray ◽  
Bhaskar Mazumder
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Topical Delivery ◽  
Lipid Nanoparticles ◽  
In Vivo Evaluation ◽  
Solid Lipid

Erythropoietin-loaded solid lipid nanoparticles: Preparation, optimization, and in vivo evaluation

2019 ◽  
Vol 178 ◽  
pp. 307-316 ◽  
Author(s):  
Tahereh Dara ◽  
Alireza Vatanara ◽  
Mohsen Nabi Meybodi ◽  
Molood Alsadat Vakilinezhad ◽  
Soroor Sadegh Malvajerd ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
In Vivo Evaluation ◽  
Solid Lipid

Solid lipid nanoparticles for delivery of andrographolide across the blood-brain barrier: in vitro and in vivo evaluation

2018 ◽  
Vol 161 ◽  
pp. 302-313 ◽  
Author(s):  
Giulia Graverini ◽  
Vieri Piazzini ◽  
Elisa Landucci ◽  
Daniela Pantano ◽  
Pamela Nardiello ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Brain Barrier ◽  
In Vivo Evaluation ◽  
Solid Lipid ◽  
Blood Brain

A comparative in vivo evaluation of anti-alzheimer activity of bacopa extract and its solid lipid nanoparticles

2020 ◽  
Vol 16 ◽  
Author(s):  
Rajesh Kumar ◽  
Rajeev Garg ◽  
Navneet Khurana
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Solid Lipid Nanoparticles ◽  
Extended Period ◽  
Lipid Nanoparticles ◽  
Nootropic Activity ◽  
Active Constituent ◽  
In Vivo Evaluation ◽  
Solid Lipid

Purpose: Bacopa monnieri (Brahmi; family Scrophulariaceae) is a well-known plant known for its nootropic activity. Delivery of Bacosides (active constituent) is limited at the site of action owing to the existence of blood-brain barrier (BBB). In order to take the bacoside rich extract (BRE) across BBB, formulated solid lipid nanoparticles (SLNs) were used. Objective: The objective of this work was to evaluate the pharmacokinetic and pharmacodynamic behavior (in vivo potential) of the prepared SLNs containing BRE in comparison to BRE alone for the treatment of Alzheimer’s disease. Methods: Swiss albino male mice (25-30 gm) were used for the study. The pharmacokinetic as well as pharmacodynamic evaluation of formulated SLNs was performed in comparison to BRE in scopolamine-induced amnesia model. Results: BRE-loaded SLNs were found to be significantly more effective than BRE in alleviating the neurodegeneration. The pharmacokinetic study revealed the improved bioavailability of prepared SLNs with the potential of sustaining the drug release in mice for an extended period of time. Conclusion: The results demonstrated that the SLNs may be considered a potential delivery system for taking BRE across BBB to treat Alzheimer’s disease.

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