Pan-Proteomics to Analyze the Functional Complexity of Organisms

2021 ◽  
pp. 81-98
Author(s):  
Muhammad Tahir ul Qamar ◽  
Barira Zahid ◽  
Fatima Khalid ◽  
Anam Naz ◽  
Jia-Ming Song ◽  
...  
2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Eveling Garzón Fontalvo

AbstractThis paper deals with the category of number in Latin, specifically with the different meanings of the plural with verbal nouns. In the first section, I establish a reference framework on the concept of number, and in particular the so-called “number anomalies”. The second part of the paper addresses the functional complexity of the category of number itself, so it presents and exemplifies the four different meanings of plural forms with verbal nouns and explains them in light of the concepts of prototype and recategorization. The third section aims to identify the factors yielding a determined plural reading; in this way, I explain the connection between some meanings of the plural and the types of events that verbal nouns describe. Lastly, in the final section, I discuss the main results of this study.


Land ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 398
Author(s):  
Eliza Sochacka ◽  
Magdalena Rzeszotarska-Pałka

A growing number of urban interventions, such as culture-led regeneration strategies, has emerged alongside growing awareness of the concept of re-urbanization. These interventions evolve to create a holistic urban vision, with aims to promote social cohesion and strengthen local identity as opposed to traditional goals of measuring the economic impact of new cultural developments. Szczecin’s, Poland urban strategy is focused on the expansion of culture—a condition for improving the quality of life and increasing the city’s attractiveness. This article assesses the potential for re-urbanization of Szczecin’s flagship cultural developments. Questionnaire surveys and qualitative research methods were used to assess the characteristics that distinguish cultural projects in the formal, location-related, functional, and symbolic layers, as well as examining their social perception. The results show that the strength of these indicators of urbanscape identity affects how the cultural developments are assessed by the society. Semiotic coherence and functional complexity of the structures have a significant impact on the sense of identification, while their monumentality and exposure contribute to the assessment of the impact on their surroundings. A development with a firm identity, embedded in the city’s tradition not only preserves the cultural heritage of the city but also makes inhabitants feel association with the new project.


Genetics ◽  
1998 ◽  
Vol 149 (3) ◽  
pp. 1407-1426 ◽  
Author(s):  
Lee A Smith ◽  
Alexandre A Peixoto ◽  
Elena M Kramer ◽  
Adriana Villella ◽  
Jeffrey C Hall

Abstract We show by molecular analysis of behavioral and physiological mutants that the Drosophila Dmca1A calcium-channel α1 subunit is encoded by the cacophony (cac) gene and that nightblind-A and lethal(1)L13 mutations are allelic to cac with respect to an expanded array of behavioral and physiological phenotypes associated with this gene. The cacS mutant, which exhibits defects in the patterning of courtship lovesong and a newly revealed but subtle abnormality in visual physiology, is mutated such that a highly conserved phenylalanine (in one of the quasi-homologous intrapolypeptide regions called IIIS6) is replaced by isoleucine. The cacH18 mutant exhibits defects in visual physiology (including complete unresponsiveness to light in certain genetic combinations) and visually mediated behaviors; this mutant (originally nbAH18) has a stop codon in an alternative exon (within the cac ORF), which is differentially expressed in the eye. Analysis ofthe various courtship and visual phenotypes associated with this array ofcac mutants demonstrates that Dmca1A calcium channels mediate multiple, separable biological functions; these correlate in part with transcript diversity generated via alternative splicing.


RSC Advances ◽  
2018 ◽  
Vol 8 (57) ◽  
pp. 32440-32453 ◽  
Author(s):  
Kornphimol Kulthong ◽  
Loes Duivenvoorde ◽  
Barbara Z. Mizera ◽  
Deborah Rijkers ◽  
Guillaume ten Dam ◽  
...  

Novel microfluidic technologies allow the manufacture ofin vitroorgan-on-a-chip systems that hold great promise to adequately recapitulate the biophysical and functional complexity of organs foundin vivo.


Author(s):  
Ioan Florin GHIURCO ◽  
Aurel DAMIAN ◽  
Vasile Florin RUS ◽  
Cristian MARTONOS ◽  
Maria Cătălina MATEI ◽  
...  

Hepatocytes represent the majority of the liver cell population and are arranged in the form of cords placed in intimate contact with the sinusoidal capillaries. The functional complexity corroborated with the intensity of the activity of hepatocytes requires large amounts of energy. The organelles involved in the production of chemical energy used in the activity of hepatocytes are the mitochondria. The purpose of this study was to verify the mitochondrial load of hepatocytes in all areas of the classical hepatic lobules, in order to indirectly assess the intensity of hepatocyte activity in each area. Materials and Methods Five fresh corpses of chinchilla (Chinchilla lanigera) from an independent breeder from Bistrița-Năsăud county were used. Liver fragments were harvested and fixated in Kolster’s solution for 24 hours, stained with Heidenhain ferric hematoxylin, and assessed using Olympus BX41 microscope. Fixation with Kolster's solution and the staining with Heidenhain's iron hematoxylin clearly shows the hepatocytic mitochondria in shades from gray to black. The liver lobules displayed an uneven distribution of mitochondria depending on the area. In zone 1 of the classical hepatic lobule, the degree of loading of hepatocytes with mitochondria is larger than in zone 2 and much larger than in zone 3. Morphological features of the hepatocytes, including the number and distribution of mitochondria in the hepatic lobules, should improve the understanding of the physiology and pathology of the liver.


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