Choroid Plexus Carcinoma in the Lateral Ventricle

A red, firm 3.5x3.0x3.0cm mass was found within the right lateral ventricle, compressing the hippocampus and thalamus of the brain of a 4-year-old cow. The pituitary was enlarged and firm. Histologically, both the brain and pituitary masses consisted of moderately pleomorphic epithelial cells arranged as rosettes or sheets supported by a delicate fibrovascular stroma. Based on anatomical localization, histopathological and immunohistochemical findings, a diagnosis of choroid plexus carcinoma with pituitary metastasis was made.

Download Full-text

A Case Report of a Choroid Plexus Carcinoma Spontaneously Occurring in the Right Lateral Ventricle of a 14-Week-Old, Female Donryu Rat

Toxicologic Pathology ◽

10.1080/01926230490274326 ◽

2004 ◽

Vol 32 (2) ◽

pp. 264-268 ◽

Cited By ~ 6

Author(s):

Takasumi Shimomoto ◽

Midori Yoshida ◽

Masakazu Takahashi ◽

Fumiyuki Uematsu ◽

Akihiko Maekawa ◽

...

Keyword(s):

Choroid Plexus ◽

Lateral Ventricle ◽

World Literature ◽

S100 Protein ◽

Protein A ◽

Choroid Plexus Carcinoma ◽

Ependymal Cells ◽

Cell Layers ◽

The Right ◽

Donryu Rat

We encountered a brain tumor arising in the right lateral ventricle of a 14-week-old, female Donryu rat and investigated its histological and immunohistochemical characteristics. Macroscopically, the tumor appeared as a grayish mass with a size of 10 mm in diameter, present in front of the right hemicerebrum and well circumscribed on the cut surface. Histological examination revealed the tumor to be a hypercellular mass occupying the front part of the right lateral ventricle and expanding into the area in front of the hemicerebrum, continuing to the ependymal area at its edge. The tumor was constituted by columnar- or pleomorphic-shaped, highly atypical cells of epithelial origin surrounding fibrovascular cores as single or multiple cell layers. Growth was papillary with high proliferating activity. Immunohistochemically, the tumor cells proved positive for cytokeratin but negative for vimentin, S100 protein or glial fibrillary acidic protein, a profile characteristic for the epithelial cells of the choroid plexus, whereas the ependymal cells were found to be positive for all 4 items. In conclusion, the present tumor was diagnosed as a rat choroid plexus carcinoma, only the third such case to be reported in the world literature, with particular features.

Download Full-text

Preoperative Devascularization of Choroid Plexus Tumors: Specific Issues about Anatomy and Embolization Technique

Brain Sciences ◽

10.3390/brainsci11050540 ◽

2021 ◽

Vol 11 (5) ◽

pp. 540

Author(s):

Valentina Baro ◽

Joseph Domenico Gabrieli ◽

Giacomo Cester ◽

Ignazio D’Errico ◽

Andrea Landi ◽

...

Keyword(s):

Choroid Plexus ◽

Lateral Ventricle ◽

Choroid Plexus Carcinoma ◽

Embolic Agent ◽

Preoperative Embolization ◽

Anterior Choroidal Artery ◽

Choroid Plexus Tumors ◽

Occlusion Time ◽

Anterior Choroidal ◽

Choroidal Artery

(1) Background: Surgical treatment of choroid plexus tumors is challenging, burdened by a notable risk of bleeding. Neoadjuvant chemotherapy and preoperative embolization have been attempted, with encouraging results; however, the consensus on these procedures is lacking. (2) Methods: We present a case of a 10-month-old girl who underwent preoperative embolization of a hemorrhagic choroid plexus carcinoma of the lateral ventricle via the anterior choroidal artery, followed by total resection. (3) Results: The endovascular procedure was successfully completed, despite the rectification of the anterior choroidal artery associated with the absence of flow proximal to the plexal point. Minimal bleeding was observed during resection and the patient remained neurologically intact. (4) Conclusions: The time from entrance to exit in the anterior choroidal artery should be monitored and regarded as a potential ‘occlusion time’ in this specific group of patients. Nevertheless, our case supports the feasibility and effectiveness of preoperative embolization of a choroid plexus carcinoma of the lateral ventricle via the anterior choroidal artery, without complications. Furthermore, we suggest the use of a fast-embolic agent, such as N-butyl cyanoacrylate glue, as the preferred agent for this specific pathology and patient population.

Download Full-text

Choroid plexus carcinoma of the lateral ventricle.

American Journal of Roentgenology ◽

10.2214/ajr.169.5.9353468 ◽

1997 ◽

Vol 169 (5) ◽

pp. 1400-1400 ◽

Cited By ~ 3

Author(s):

L A Grygotis ◽

F S Chew

Keyword(s):

Choroid Plexus ◽

Lateral Ventricle ◽

Choroid Plexus Carcinoma

Download Full-text

Choroid plexus carcinoma of the lateral ventricle report of a case in an adult

Clinical Neurology and Neurosurgery ◽

10.1016/0303-8467(94)90029-9 ◽

1994 ◽

Vol 96 (1) ◽

pp. 47-51 ◽

Cited By ~ 6

Author(s):

Mustafa K. Başkaya ◽

Selim Erekul ◽

Nihat Egemen ◽

Hamit Z. Gökalp ◽

Ayşe Sertçelik

Keyword(s):

Choroid Plexus ◽

Lateral Ventricle ◽

Choroid Plexus Carcinoma

Download Full-text

ATRT-04. INHERITED RHABDOID PREDISPOSITION SYNDROME: A CASE OF CHOROID PLEXUS CARCINOMA AND ATYPICAL TERATOID RHABDOID TUMOR IN SIBLINGS

Neuro-Oncology ◽

10.1093/neuonc/noaa222.004 ◽

2020 ◽

Vol 22 (Supplement_3) ◽

pp. iii276-iii276

Author(s):

Alexis Judd ◽

Erin Wright ◽

Sarah Rush

Keyword(s):

Overall Survival ◽

Choroid Plexus ◽

Disease Recurrence ◽

Genetic Alterations ◽

Rhabdoid Tumor ◽

Choroid Plexus Carcinoma ◽

High Dose ◽

Atypical Teratoid Rhabdoid Tumor ◽

Increased Risk ◽

Atypical Teratoid

Abstract Choroid plexus carcinoma (CPC) and Atypical teratoid/rhabdoid tumor (ATRT) are aggressive, malignant brain cancers most commonly arising in children less than 3 years of age. These tumors often have genetic alterations in the tumor suppressor gene SMARCB1/INI1. Rhabdoid predisposition syndrome (RTPS) categorizes patients with germline mutations in SMARCB1 or SMARCA4, leading to a markedly increased risk of developing rhabdoid tumors. Both CPC and ATRT have been demonstrated in patients with these rhabdoid predisposition syndromes. In general, these tumors tend to have a poor prognosis. However, with the presence of a SMARCB1 mutation they may have improved overall survival. We present two interesting cases of siblings with maternally inherited SMARCB1 mutations: one a 21-month-old male who presented with an ATRT and another a 10 month old female who presented with a CPC. The ATRT was treated as per the Children’s Oncology Group study ACNS0333 with high dose chemotherapy and stem cell rescue as well as cranial radiation. The CPC was treated as per CPT-SIOP 2009 with etoposide, cyclophosphamide and vincristine. Unlike other patients with these aggressive tumors, both of these patients are alive without evidence of disease recurrence 8 and 7 years post therapy, respectively. Additional genomic testing on both tumors is currently pending in order to potentially identify other mutations that may impact survival. These cases further illustrate the similar profile of two very different tumors with improved overall survival that may be secondary to mutations in SMARCB1 in RTPS.

Download Full-text