scholarly journals Нелинейная динамика паттернов импульсной активности ноцицептивных нейронов при коррекции повреждающего болевого воздействия

2019 ◽  
Vol 89 (3) ◽  
pp. 465
Author(s):  
О.Е. Дик
Keyword(s):  
Bifurcation Analysis ◽  
Active Ingredient ◽  
Activity Pattern ◽  
Neuron Model ◽  
Nociceptive Neuron ◽  
Firing Activity ◽  
Comenic Acid ◽  
Pain Stimulation ◽  
Activation Gating ◽  
Nonopioid Analgesic

AbstractA bifurcation analysis of a nociceptive neuron model was performed to study how the firing activity pattern changes when an antinociceptive response to damaging pain stimulation arises in rat dorsal ganglia. Ectopic train activity was found to arise in the model. Suppression of train activity was demonstrated to proceed solely through modification of the activation gating structure of the Na _ V 1.8 slow sodium channel in response to comenic acid, which exerts an analgesic effect and is an active ingredient of the new nonopioid analgesic Anoceptin.

Bifurcation analysis and circuit implementation for a tabu learning neuron model

2020 ◽  
Vol 121 ◽  
pp. 153235 ◽  
Author(s):  
Bocheng Bao ◽  
Liping Hou ◽  
Yongxin Zhu ◽  
Huagan Wu ◽  
Mo Chen
Keyword(s):  
Bifurcation Analysis ◽  
Neuron Model ◽  
Circuit Implementation

scholarly journals THE GABA-ERGIC SYSTEM DOES NOT CONTROL THE NOCICEPTIVE RESPONSES OF PRIMARY SENSORY NEURON

2019 ◽  
Vol 19 (1S) ◽  
pp. 44-45
Author(s):  
V A Penniyaynen ◽  
S A Podzorova ◽  
S G Terekhin ◽  
B V Krylov ◽  
V B Plakhova
Keyword(s):  
Sensory Neuron ◽  
Sensory Neurons ◽  
Nervous Tissue ◽  
Molecular Mechanisms ◽  
Primary Sensory Neuron ◽  
Nociceptive Neuron ◽  
Wide Range ◽  
Nociceptive Responses ◽  
Activation Gating

The aim of the study was to elucidate the molecular mechanisms of the interconnection of the GABA-ergic and nociceptive systems at the level of the peripheral division of the CNS. The data obtained indicate that GABA does not affect the activation gating device of the NaV1.8 channel of the primary sensory neuron responsible for coding pain signals.This agent in a wide range of concentrations also does not affect the growth of neurites of sensory neurons of embryonic nervous tissue. These results confirm our assumption, expressed earlier that the asynaptic membrane of the primary nociceptive neuron is not under the control of the GABA-ergic system.

scholarly journals Hopf Bifurcation Analysis in a Tabu Learning Neuron Model with Two Delays

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Yingguo Li
Keyword(s):  
Hopf Bifurcation ◽  
Theoretical Analysis ◽  
Bifurcation Analysis ◽  
Neuron Model ◽  
Dynamical Behavior ◽  
Bifurcation Parameter ◽  
Nonlinear Dynamical ◽  
Numerical Examples ◽  
Two Delays

We consider the nonlinear dynamical behavior of a tabu leaning neuron model with two delays. By choosing the sum of the two delays as a bifurcation parameter, we prove that Hopf bifurcation occurs in the neuron. Some numerical examples are also presented to verify the theoretical analysis.

Bifurcation analysis of a thalamic relay neuron model

2009 ◽  
Author(s):  
Huibing Yin ◽  
Charles L. Cox ◽  
Prashant G. Mehta ◽  
Uday V. Shanbhag
Keyword(s):  
Bifurcation Analysis ◽  
Neuron Model ◽  
Relay Neuron ◽  
Thalamic Relay
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