scholarly journals Confocal Laser Endomicroscopy and Optical Coherence Tomography for the Diagnosis of Prostate Cancer: A Needle-Based, In Vivo Feasibility Study Protocol (IDEAL Phase 2A)

2018 ◽  
Vol 7 (5) ◽  
pp. e132 ◽  
Author(s):  
Abel Swaan ◽  
Christophe K Mannaerts ◽  
Matthijs JV Scheltema ◽  
Jakko A Nieuwenhuijzen ◽  
C Dilara Savci-Heijink ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Optical Coherence Tomography ◽  
Feasibility Study ◽  
Study Protocol ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Optical Coherence

scholarly journals Confocal Laser Endomicroscopy and Optical Coherence Tomography for the Diagnosis of Prostate Cancer: A Needle-Based, In Vivo Feasibility Study Protocol (IDEAL Phase 2A) (Preprint)

2018 ◽  
Author(s):  
Abel Swaan ◽  
Christophe K Mannaerts ◽  
Matthijs J V Scheltema ◽  
Jakko A Nieuwenhuijzen ◽  
C Dilara Savci-Heijink ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Optical Coherence Tomography ◽  
Real Time ◽  
Imaging Modality ◽  
Imaging Techniques ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Optical Coherence ◽  
Optical Coherence Tomography Imaging

BACKGROUND Focal therapy for prostate cancer has been proposed as an alternative treatment to whole-gland therapies in selected men to diminish side effects in localized prostate cancer. As nowadays imaging cannot offer complete prostate cancer disease characterization, multicore systematic biopsies are recommended (transrectal or transperineal). Optical imaging techniques such as confocal laser endomicroscopy and optical coherence tomography allow in vivo, high-resolution imaging. Moreover, they can provide real-time visualization and analysis of tissue and have the potential to offer additive diagnostic information. OBJECTIVE This study has 2 separate primary objectives. The first is to assess the technical feasibility and safety of in vivo focal imaging with confocal laser endomicroscopy and optical coherence tomography. The second is to identify and define characteristics of prostate cancer and normal prostate tissue in confocal laser endomicroscopy and optical coherence tomography imaging by comparing these images with the corresponding histopathology. METHODS In this prospective, in vivo feasibility study, needle-based confocal laser endomicroscopy and optical coherence tomography imaging will be performed before transperineal template mapping biopsy or radical prostatectomy. First, confocal laser endomicroscopy and optical coherence tomography will be performed in 4 patients (2 for each imaging modality) undergoing transperineal template mapping biopsy to assess the feasibility and safety of confocal laser endomicroscopy and optical coherence tomography. If proven to be safe and feasible, confocal laser endomicroscopy and optical coherence tomography will be performed in 10 patients (5 for each imaging modality) undergoing radical prostatectomy. Confocal laser endomicroscopy and optical coherence tomography images will be analyzed by independent, blinded observers. Confocal laser endomicroscopy– and optical coherence tomography–based qualitative and quantitative characteristics and histopathology will be compared. The study complies with the IDEAL (Idea, Development, Exploration, Assessment, Long-term study) stage 2a recommendations. RESULTS At present, the study is enrolling patients and results and outcomes are expected in 2019. CONCLUSIONS Confocal laser endomicroscopy and optical coherence tomography are promising optical imaging techniques that can visualize and analyze tissue structure, possible tumor grade, and architecture in real time. They can potentially provide real-time, high-resolution microscopic imaging and tissue characteristics of prostate cancer in conjunction with magnetic resonance imaging or transrectal ultrasound fusion-guided biopsy procedures. This study will provide insight into the feasibility and tissue-specific characteristics of confocal laser endomicroscopy and optical coherence tomography for real-time optical analysis of prostate cancer. CLINICALTRIAL ClinicalTrials.gov NCT03253458; https://clinicaltrials.gov/ct2/show/NCT03253458 (Archived by WebCite at http://www.webcitation.org/6z9owM66B) REGISTERED REPORT IDENTIFIER RR1-10.2196/9813

Visualization of brain microvasculature and blood flow in vivo: Feasibility study using confocal laser endomicroscopy

2021 ◽  
Author(s):  
Evgenii Belykh ◽  
Xiaochun Zhao ◽  
Brandon Ngo ◽  
Dara S. Farhadi ◽  
Adam Kindelin ◽  
...  
Keyword(s):  
Blood Flow ◽  
Feasibility Study ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Brain Microvasculature

In vivo characterisation of superficial colorectal neoplastic lesions with high-resolution probe-based confocal laser endomicroscopy in combination with video-mosaicing: A feasibility study to enhance routine endoscopy

2010 ◽  
Vol 42 (11) ◽  
pp. 791-797 ◽  
Author(s):  
Giovanni D. De Palma ◽  
Stefania Staibano ◽  
Saverio Siciliano ◽  
Marcello Persico ◽  
Stefania Masone ◽  
...  
Keyword(s):  
High Resolution ◽  
Feasibility Study ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Video Mosaicing ◽  
Neoplastic Lesions

scholarly journals Advances in Optical Coherence Tomography and Confocal Laser Endomicroscopy in Pulmonary Diseases

Respiration ◽  
2019 ◽  
Vol 99 (3) ◽  
pp. 190-205 ◽  
Author(s):  
Annika Goorsenberg ◽  
Kirsten A. Kalverda ◽  
Jouke Annema ◽  
Peter Bonta
Keyword(s):  
Optical Coherence Tomography ◽  
Pulmonary Diseases ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Optical Coherence

Tu1154 Cost-Utility Analysis for Surveillance of Barrett's Esophagus Evaluating Standard Biopsies Compared to Optical Coherence Tomography and Confocal Laser Endomicroscopy

2017 ◽  
Vol 85 (5) ◽  
pp. AB559-AB560 ◽  
Author(s):  
Monica Saumoy ◽  
Yecheskel Schneider ◽  
Aleksey A. Novikov ◽  
Amy Tyberg ◽  
Michel Kahaleh ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Cost Utility ◽  
Cost Utility Analysis ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Optical Coherence ◽  
Utility Analysis

Optical coherence tomography and confocal laser endomicroscopy in pulmonary diseases

2017 ◽  
Vol 23 (3) ◽  
pp. 275-283 ◽  
Author(s):  
Lizzy Wijmans ◽  
Julia N.S. d’Hooghe ◽  
Peter I. Bonta ◽  
Jouke T. Annema
Keyword(s):  
Optical Coherence Tomography ◽  
Pulmonary Diseases ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Optical Coherence

Optical coherence tomography (OCT) for investigating main pancreatic duct strictures: A pilot “in vivo” feasibility study

2006 ◽  
Vol 38 ◽  
pp. S40
Author(s):  
A. Mariani ◽  
B. Mangiavillano ◽  
P.G. Arcidiacono ◽  
E. Masci ◽  
S. Di Pietro ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Pancreatic Duct ◽  
Feasibility Study ◽  
Main Pancreatic Duct ◽  
Optical Coherence
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