Malignant Skin and Subcutaneous Neoplasms in Adults: Multimodality Imaging With CT, MRI, and18F-FDG PET/CT

Since its introduction into clinical practice, multimodality imaging has revolutionized diagnostic imaging for both oncologic and non-oncologic pathologies. 18F-fluorodeoxyglucose (18F-FDG) PET/CT imaging which takes advantage of increased anaerobic glycolysis that occurs in tumor cells (Warburg effect) has gained significant clinical relevance in the management of most, if not all oncologic conditions. Because FDG is taken by both normal and abnormal tissues, PET/CT imaging may demonstrate several normal variants and imaging pitfalls. These may ultimately impact disease detection and diagnostic accuracy. Imaging specialists (nuclear medicine physicians and radiologists) must demonstrate a thorough understanding of normal and physiologic variants in the distribution of 18F-FDG; including potential imaging pitfalls and technical artifacts to minimize misinterpretation of images. The normal physiologic course of 18F-FDG results in a variable degree of uptake in the stomach, liver, spleen, small and large bowel. Urinary excretion results in renal, ureteric, and urinary bladder uptake. Technical artifacts can occur due to motion, truncation as well as the effects of contrast agents and metallic hardware. Using pictorial illustrations, this paper aims to describe the variants of physiologic 18F-FDG uptake that may mimic pathology as well as potential benign conditions that may result in misinterpretation of PET/CT images in common oncologic conditions of the abdomen and pelvis.

Download Full-text

Cardiovascular Mechanisms In Covid-19: Methodology of A Prospective Observational Multimodality Imaging Study (COSMIC-19 study)

10.21203/rs.3.rs-77405/v1 ◽

2020 ◽

Author(s):

Shirjel Alam ◽

Anoop Shah ◽

Kevin Onyinkwa ◽

Edward Nganga ◽

Samuel Gitau ◽

...

Keyword(s):

Computed Tomography ◽

Fdg Pet ◽

Clinical Decision Making ◽

Multimodality Imaging ◽

Cardiac Injury ◽

Imaging Study ◽

Clinical Decision ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

Abstract Background: 8-28% of patients infected with COVID-19 have evidence of cardiac injury, and this is associated with an adverse prognosis. The cardiovascular mechanisms of injury are poorly understood and speculative. We aim to use multimodality cardiac imaging including cardiac magnetic resonance (CMR) imaging, computed tomography coronary angiography (CTCA) and positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro- D-glucose integrated with computed tomography (18F-FDG-PET/CT) to identify the cardiac pathophysiological mechanisms related to COVID-19 infections.Methods: This is a single-centre exploratory observational study aiming to recruit 50 patients with COVID-19 infection who will undergo cardiac biomarker sampling. Of these, 30 patients will undergo combined CTCA & 18F-FDG-PET/CT, followed by CMR. Prevalence of obstructive and non-obstructive atherosclerotic coronary disease will be assessed using CTCA. CMR will be used to identify and characterise myocardial disease including presence of cardiac dysfunction, myocardial fibrosis, myocardial oedema and myocardial infarction. 18F-FDG-PET/CT will identify vascular and cardiac inflammation. Primary endpoint will be the presence of cardiovascular pathology and the association with troponin levels.Discussion: The results of the study will identify the presence and modality of cardiac injury associated COVID-19 infection, and the utility of multi-modality imaging in diagnosing such injury. This will further inform clinical decision making during the pandemic.TRIAL REGISTRATION: This study has been retrospectively registered at the ISRCTN registry (ID ISRCTN12154994) on 14th August 2020. Accessible at www.isrctn.com/ISRCTN12154994

Download Full-text

A pictoral review on somatostatin receptor scintigraphy in neuroendocrine tumors: The role of multimodality imaging with SRS and GLUT receptor imaging with FDG PET-CT

Indian Journal of Radiology and Imaging ◽

10.4103/0971-3026.111478 ◽

2012 ◽

Vol 22 (4) ◽

pp. 267 ◽

Cited By ~ 3

Author(s):

Venkatesh Rangarajan ◽

Sneha Shah ◽

Nilendu Purandare ◽

Archi Agrawal

Keyword(s):

Neuroendocrine Tumors ◽

Fdg Pet ◽

Multimodality Imaging ◽

Somatostatin Receptor ◽

Somatostatin Receptor Scintigraphy ◽

Receptor Imaging ◽

Pet Ct ◽

Receptor Scintigraphy ◽

Fdg Pet Ct

Download Full-text

CardiOvaScular Mechanisms In Covid-19: methodology of a prospective observational multimodality imaging study (COSMIC-19 study)

BMC Cardiovascular Disorders ◽

10.1186/s12872-021-02027-0 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Shirjel R. Alam ◽

Anoop S. V. Shah ◽

Kevin O. Ombati ◽

Edward Nganga ◽

Samuel Gitau ◽

...

Keyword(s):

Computed Tomography ◽

Fdg Pet ◽

Clinical Decision Making ◽

Multimodality Imaging ◽

Cardiac Injury ◽

Imaging Study ◽

Clinical Decision ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

Abstract Background 8–28% of patients infected with COVID-19 have evidence of cardiac injury, and this is associated with an adverse prognosis. The cardiovascular mechanisms of injury are poorly understood and speculative. We aim to use multimodality cardiac imaging including cardiac magnetic resonance (CMR) imaging, computed tomography coronary angiography (CTCA) and positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro-d-glucose integrated with computed tomography (18F-FDG-PET/CT) to identify the cardiac pathophysiological mechanisms related to COVID-19 infections. Methods This is a single-centre exploratory observational study aiming to recruit 50 patients with COVID-19 infection who will undergo cardiac biomarker sampling. Of these, 30 patients will undergo combined CTCA and 18F-FDG-PET/CT, followed by CMR. Prevalence of obstructive and non-obstructive atherosclerotic coronary disease will be assessed using CTCA. CMR will be used to identify and characterise myocardial disease including presence of cardiac dysfunction, myocardial fibrosis, myocardial oedema and myocardial infarction. 18F-FDG-PET/CT will identify vascular and cardiac inflammation. Primary endpoint will be the presence of cardiovascular pathology and the association with troponin levels. Discussion The results of the study will identify the presence and modality of cardiac injury associated COVID-19 infection, and the utility of multi-modality imaging in diagnosing such injury. This will further inform clinical decision making during the pandemic. Trial Registration: This study has been retrospectively registered at the ISRCTN registry (ID ISRCTN12154994) on 14th August 2020. Accessible at https://www.isrctn.com/ISRCTN12154994

Download Full-text

Multimodality imaging of atherosclerotic plaque activity and composition using FDG-PET/CT and MRI in carotid and femoral arteries

Atherosclerosis ◽

10.1016/j.atherosclerosis.2009.04.023 ◽

2009 ◽

Vol 207 (1) ◽

pp. 139-143 ◽

Cited By ~ 110

Author(s):

Stephane S. Silvera ◽

Hamza el Aidi ◽

James H.F. Rudd ◽

Venkatesh Mani ◽

Lingde Yang ◽

...

Keyword(s):

Atherosclerotic Plaque ◽

Fdg Pet ◽

Multimodality Imaging ◽

Femoral Arteries ◽

Pet Ct ◽

Fdg Pet Ct ◽

Ct And Mri

Download Full-text

FDG-PET/CT in a Patient with Poor-Risk Non-Seminoma Testis with Mature Teratoma and Secondary Gliosarcoma: Multimodality Imaging for Guiding Multimodality Treatment

Nuclear Medicine and Molecular Imaging ◽

10.1007/s13139-015-0321-9 ◽

2015 ◽

Vol 49 (3) ◽

pp. 237-240 ◽

Cited By ~ 3

Author(s):

Elske Quak ◽

Iringo Kovacs ◽

Wim J. G. Oyen ◽

Winette T. A. van der Graaf

Keyword(s):

Fdg Pet ◽

Multimodality Imaging ◽

Mature Teratoma ◽

Multimodality Treatment ◽

Poor Risk ◽

Pet Ct ◽

Fdg Pet Ct

Download Full-text

Role of 18F-FDG PET/CT in Erdheim–Chester Disease in the Era of Multimodality Imaging

Indian Journal of Radiology and Imaging ◽

10.1055/s-0041-1736164 ◽

2021 ◽

Author(s):

Bhargavi Jois ◽

Rupa Ananthasivan ◽

Parameswaran R. V. Sudarshan Rawat ◽

Susmita Rakshit

Keyword(s):

Fdg Pet ◽

Multimodality Imaging ◽

Disease Extent ◽

Ct Guided ◽

Erdheim Chester Disease ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct ◽

Erdheim Chester ◽

Chester Disease

AbstractErdheim–Chester disease is a rare disease with systemic non-Langerhans cell histiocytosis, the diagnosis of which with conventional imaging modalities is challenging. We describe a case of a 73-year-old woman who was referred with a progressive history of bilateral proptosis. The magnetic resonance imaging (MRI) orbit demonstrated bilateral orbital masses with optic nerve encasement. A subsequent 18F-FDG PET/CT scan showed multi-organ disease with involvement of the orbits, pericardium, aorta, pararenal fascia, and appendicular bones. Metabolically active, easily accessible areas were selected for CT-guided biopsy. The biopsy showed sheets of foamy histiocytes with the expression of CD 68 and CD 163 consistent with a diagnosis of Erdheim–Chester disease. The FDG PET/CT played a pivotal role in establishing the diagnosis with the assessment of disease extent and further guided in the targeted biopsy.

Download Full-text