Differentiation Between Hepatocellular Carcinoma Showing Hyperintensity on the Hepatobiliary Phase of Gadoxetic Acid–Enhanced MRI and Focal Nodular Hyperplasia by CT and MRI

2018 ◽  
Vol 211 (2) ◽  
pp. 347-357 ◽  
Author(s):  
Azusa Kitao ◽  
Osamu Matsui ◽  
Norihide Yoneda ◽  
Ryuichi Kita ◽  
Kazuto Kozaka ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Focal Nodular Hyperplasia ◽  
Gadoxetic Acid ◽  
Hepatobiliary Phase ◽  
Enhanced Mri ◽  
Nodular Hyperplasia ◽  
Ct And Mri

Gadoxetic Acid–Enhanced Hepatobiliary-Phase Magnetic Resonance Imaging for Delineation of Focal Nodular Hyperplasia

2018 ◽  
Vol 42 (5) ◽  
pp. 667-674 ◽  
Author(s):  
Ruofan Sheng ◽  
Viktoria Palm ◽  
Philipp Mayer ◽  
Theresa Mokry ◽  
Anne Katrin Berger ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Focal Nodular Hyperplasia ◽  
Gadoxetic Acid ◽  
Hepatobiliary Phase ◽  
Resonance Imaging ◽  
Nodular Hyperplasia

Value of Texture Analysis on Gadoxetic Acid–Enhanced MRI for Differentiating Hepatocellular Adenoma From Focal Nodular Hyperplasia

2019 ◽  
Vol 212 (3) ◽  
pp. 538-546 ◽  
Author(s):  
Roberto Cannella ◽  
Balasubramanya Rangaswamy ◽  
Marta I. Minervini ◽  
Amir A. Borhani ◽  
Allan Tsung ◽  
...  
Keyword(s):  
Texture Analysis ◽  
Focal Nodular Hyperplasia ◽  
Hepatocellular Adenoma ◽  
Gadoxetic Acid ◽  
Enhanced Mri ◽  
Nodular Hyperplasia

Noninvasive diagnosis of hepatocellular carcinoma on gadoxetic acid-enhanced MRI: can hypointensity on the hepatobiliary phase be used as an alternative to washout?

2015 ◽  
Vol 25 (10) ◽  
pp. 2859-2868 ◽  
Author(s):  
Ijin Joo ◽  
Jeong Min Lee ◽  
Dong Ho Lee ◽  
Ju Hyeon Jeon ◽  
Joon Koo Han ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gadoxetic Acid ◽  
Noninvasive Diagnosis ◽  
Hepatobiliary Phase ◽  
Enhanced Mri

scholarly journals Diagnostic Per-Patient Accuracy of an Abbreviated Hepatobiliary Phase Gadoxetic Acid–Enhanced MRI for Hepatocellular Carcinoma Surveillance

2015 ◽  
Vol 204 (3) ◽  
pp. 527-535 ◽  
Author(s):  
Robert M. Marks ◽  
Andrew Ryan ◽  
Elhamy R. Heba ◽  
An Tang ◽  
Tanya J. Wolfson ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gadoxetic Acid ◽  
Hepatobiliary Phase ◽  
Enhanced Mri ◽  
Hepatocellular Carcinoma Surveillance

Histopathologically confirmed focal nodular hyperplasia of the liver: Gadoxetic acid-enhanced MRI characteristics

2013 ◽  
Vol 31 (5) ◽  
pp. 755-760 ◽  
Author(s):  
Christian Grieser ◽  
Ingo G. Steffen ◽  
Daniel Seehofer ◽  
Incken-Birthe Kramme ◽  
Robert Uktolseya ◽  
...  
Keyword(s):  
Focal Nodular Hyperplasia ◽  
Gadoxetic Acid ◽  
Enhanced Mri ◽  
Nodular Hyperplasia ◽  
Mri Characteristics

Hepatobiliary phase images of gadoxetic acid-enhanced MRI may improve accuracy of predicting the size of hepatocellular carcinoma at pathology

2021 ◽  
pp. 028418512110141
Author(s):  
San-Yuan Dong ◽  
Yu-Tao Yang ◽  
Wen-Tao Wang ◽  
Shuo Zhu ◽  
Wei Sun ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Correlation Coefficient ◽  
Tumor Size ◽  
Pearson Correlation ◽  
Gadoxetic Acid ◽  
Arterial Phase ◽  
Hepatobiliary Phase ◽  
Enhanced Mri ◽  
Phase Images ◽  
Mri Sequences

Background Gadoxetic acid-enhanced magnetic resonance imaging (MRI) has been widely used in clinical practice. However, scientific evidence is lacking for recommending a particular sequence for measuring tumor size. Purpose To retrospectively compare the size of hepatocellular carcinoma (HCC) measured on different gadoxetic acid-enhanced MRI sequences using pathology as a reference. Material and Methods A total of 217 patients with single HCC who underwent gadoxetic acid-enhanced MRI before surgery were included. The size of the HCC was measured by two abdominal radiologists independently on the following sequences: T1-weighted; T2-weighted; b-500 diffusion-weighted imaging (DWI); and arterial, portal venous, transitional, and hepatobiliary phases. Tumor size measured on MRI was compared with pathological size by using Pearson correlation coefficient, independent-sample t test, and Bland–Altman plot. Agreement between two readers was evaluated with intraclass correlation coefficient (ICC). Results Correlation between the MR images and pathology was high for both readers (0.899–0.955). Absolute error between MRI and pathologic assessment was lowest on hepatobiliary phase images for both readers (reader 1, 2.8±4.2 mm; reader 2, 3.2±3.4 mm) and highest on arterial phase images for reader 1 (4.9±4.4 mm) and DWI phase images for reader 2 (5.1±4.9 mm). Absolute errors were significantly different for hepatobiliary phase compared with other sequences for both readers (reader 1, P≤0.012; reader 2, P≤0.037). Inter-reader agreements for all sequence measurements were strong (0.971–0.997). Conclusion The performance of gadoxetic acid-enhanced MRI sequences varied with HCC size, and the hepatobiliary phase may be optimal among these sequences.

scholarly journals Manifestations of Hepatic Focal Nodular Hyperplasia in Hepatobiliary Phase of Enhancement by Hepatocyte-specific Contrast Agent: Comparison With Pathologic Findings

2021 ◽  
Author(s):  
Jiangfeng Xu ◽  
Liqing Zhang ◽  
Jianxun Li ◽  
Xiaojian Cui ◽  
Qingping Jiang ◽  
...  
Keyword(s):  
Focal Nodular Hyperplasia ◽  
High Intensity ◽  
The Other ◽  
Hepatobiliary Phase ◽  
Imaging Data ◽  
Low Intensity ◽  
Enhanced Mri ◽  
Pathologic Findings ◽  
Nodular Hyperplasia ◽  
Fibrous Tissues

Abstract Background: To explore the signals and diagnostic value of hepatic focal nodular hyperplasia (FNH) in the hepatobiliary phase of gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA) enhanced MRI.Methods: Imaging data of 43 pathologically proven FNH lesions from 39 patients who underwent Gd-EOB-DTPA enhanced MRI scanning at our hospital between January 2016 and June 2019 were retrospectively analyzed. The signal characteristics in the hepatobiliary phase were analyzed and compared with the pathologic findings.Results: According to the characteristics of signals in the hepatobiliary phase, the signals were classified as follows: homogenous iso-high intensity signals in 20.93% (9/43) lesions, heterogeneous iso-high intensity signals in 67.44% (29/43) lesions, homogenous low-intensity signals in 4.65% (2/43) lesions, and heterogeneous low-intensity signals in 6.98% (3/43) lesions. Two patients were with multiple lesions, where one was with 2 lesions of heterogeneous high-intensity signals, and the other with 3 lesions of heterogeneous low-intensity signals. Pathologic findings were as follows: the slices of the 38 lesions with high-intensity signals in a hepatobiliary phase were with hyperplasic hepatocytes, inflammatory cell infiltration, and malformed blood vessels. Twenty-nine of the lesions were with fiber tissues of different degrees and were classified as classic type. The remaining 9 lesions were without fibrous scars and were classified as non-classic type. The other 5 of the 43 lesions were non-classic FNH with no evident fibrous tissues, while 4 of them were with >40% steatosis in the hyperplasic hepatocytes; the immunohistochemistry showed CK7(-)/CK19(-) in 1 lesion and β-catenin (nucleus +) in another lesion. Comparisons of pathologic with imaging findings were as follows: twenty-nine lesions were with heterogeneous iso-high intensity signals, of which the slices showed evident fibrous tissues of different degrees, and the slices of 9 lesions with homogenous iso-high intensity signals in the hepatobiliary phase showed no fibrous tissues. Three lesions with heterogeneous low-intensity signals in the hepatobiliary phase showed about 80% mixed steatosis in hyperplasic hepatocytes. The other two lesions both showed homogeneous low-intensity signals in the hepatobiliary phase, where 1 lesion was with >40% macrovesicular steatosis and CK7/CK19 (-), while the other only showed β-catenin (nucleus +) by immunohistochemistry. Conclusions: The signals of FNH in the hepatobiliary phase showed various characteristics, where the signal differences were mainly associated with the number of hyperplastic hepatocytes in lesions, presence of steatosis, fibrous scars, and conditions of small bile ducts, and potentially associated with β-catenin (nucleus+). Low-intensity signals were relatively rare for FNH, thus representing a relatively major challenge for diagnosing this type FNH.

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