scholarly journals Markers of aggressiveness of non-functional pituitary adenomas with invasive growth. Literature review

2020 ◽  
Vol 16 (5) ◽  
pp. 421-426
Author(s):  
Yu.M. Urmanova ◽  
M.B. Mirtukhtaeva
Keyword(s):  
Literature Review ◽  
Pituitary Adenomas ◽  
Invasive Growth

scholarly journals Successful pregnancy after operation in an infertile woman caused by luteinizing hormone-secreting pituitary adenoma: case report and literature review

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yi Zhang ◽  
Cheng Chen ◽  
Min Lin ◽  
Kan Deng ◽  
Huijuan Zhu ◽  
...  
Keyword(s):  
Case Report ◽  
Pituitary Adenoma ◽  
Literature Review ◽  
Pituitary Adenomas ◽  
Sella Turcica ◽  
Infertile Woman ◽  
Mass Treatment ◽  
Successful Pregnancy ◽  
Case Presentation ◽  
Transsphenoidal Resection

Abstract Background Functional gonadotroph adenomas (FGAs) are rare adenomas that most commonly secrete FSH. However, solitary LH-secreting pituitary adenomas are unusual. Case presentation A 30-year-old woman with elevated LH and normal FSH presented with inability to conceive. An MRI revealed an enlarged sella turcica and an intrasellar mass. Treatment with transsphenoidal resection led to normalization of LH and estradiol, as well as successful pregnancy. And we reviewed 6 cases of LH-secreting pituitary adenomas from 1981 to 2020. Conclusions Our case is unique because of the LH-secreting pituitary adenoma without FSH hypersecretion. This case indicates that pituitary adenoma should be considered when other diseases causing infertility have been excluded.

Suprasellar pituitary adenomas: a 10-year experience in a single tertiary medical center and a literature review

Pituitary ◽  
2020 ◽  
Vol 23 (4) ◽  
pp. 367-380
Author(s):  
Jianyu Zhu ◽  
Zhicheng Wang ◽  
Yi Zhang ◽  
Jie Liu ◽  
Xiaoxu Li ◽  
...  
Keyword(s):  
Literature Review ◽  
Pituitary Adenomas ◽  
Medical Center

The immunohistochemical and radiological features of nonfunctioning pituitary adenomas

2015 ◽  
Vol 61 (6) ◽  
pp. 4-9 ◽  
Author(s):  
Anna Konstantinovna Lipatenkova ◽  
Larisa Konstantinovna Dzeranova ◽  
Ekaterina Aleksandrovna Pigarova ◽  
Nadezhda Sergeevna Dalantaeva ◽  
Ljudmila Igorevna Astaf'eva ◽  
...  
Keyword(s):  
Pituitary Adenomas ◽  
Area Under The Curve ◽  
Pituitary Hormones ◽  
Serum Markers ◽  
Invasive Growth ◽  
Null Cell ◽  
Ki 67 ◽  
Nonfunctioning Pituitary Adenomas ◽  
Radiological Features ◽  
Null Cell Adenomas

Pituitary adenomas without clinically active hypersecretion are summarized under the term nonfunctioning pituitary adenomas (NFPAs). Since there are no specific serum markers, the differential diagnosis and treatment imply special difficulties.Aim.To investigate the immunohistochemical and radiological features of NFPAs and assess the granins — chromogranin A (CgA), secretogranin II (SgII), secretoneurin (Sn) as immunohistochemical markers of NFPAs.Matherial and methods.50 pituitary adenomas excised surgically were immunostained to reveal pituitary hormones, ki-67, CgА. SgII, Sn. All patients underwent MRI, invasive growth was estimated due to J.Hardy classification (1973).Results.24 (51,1%) were gonadotropic tumors, 12 (25,5%) — null cell adenomas. Immunopositivity for ACTH was determined in 6 cases (12,7%), for GH in 5 (10,6%) cases, for PRL in 4 (8,5%). The median level of ki-67 was 2% (min. — 0.5%, max. — 7%). The CgA, SgII, Sn immunopositivity was found in 83, 93,6, 85,1% respectively, being more expressed in gonadotropinomas and null cell adenomas. Invasive growth was detected in 28 (44%) cases, among the invasive adenomas 22 tumors were giant. CgA expression is adverse prognostic factor, area under the curve (AUC) with 0,705. We did not find any correlation between ACTH-, STH-, CgII- and Sn- immunopositivity, ki-67 and invasive growth.Conclusions.Our work shows that a majority of NFPAs are truly secreting adenomas with significant numbers comprising potentially hazardous cortico- and somatotropinomas. CgA, SgII and Sn have a high expression in most of the NFPAs.

Radically resected pituitary adenomas: prognostic role of Ki 67 labeling index in a monocentric retrospective series and literature review

Pituitary ◽  
2013 ◽  
Author(s):  
Sabrina Chiloiro ◽  
Antonio Bianchi ◽  
Francesco Doglietto ◽  
Chiara de Waure ◽  
Antonella Giampietro ◽  
...  
Keyword(s):  
Literature Review ◽  
Pituitary Adenomas ◽  
Labeling Index ◽  
Prognostic Role ◽  
Ki 67

scholarly journals Aggressive forms of pituitary adenomas (literature review and clinical observation)

2017 ◽  
Vol 7 (4) ◽  
pp. 74-80
Author(s):  
P. L. Kalinin ◽  
Yu. Yu. Trunin ◽  
D. V. Fomichev ◽  
I. V. Chernov ◽  
M. V. Ryzhova
Keyword(s):  
Literature Review ◽  
Pituitary Adenomas ◽  
Clinical Observation

scholarly journals Clinical Evaluation on Non-Functional Invasive Hypophysis Adenomas

2020 ◽  
Author(s):  
Ceyhun Varim ◽  
Feyzi Gokosmanoglu ◽  
Kenan Evren Oztop
Keyword(s):  
Aggressive Behavior ◽  
Significant Relationship ◽  
Pituitary Adenomas ◽  
Immunohistochemical Staining ◽  
Clinical Course ◽  
Invasive Growth ◽  
Non Invasive ◽  
Invasive Adenoma ◽  
Aggressive Clinical Course ◽  
Endocrinology Clinic

Background There are ongoing studies to predetermine non-functional invasive pituitary adenomas which may show aggressive behavior. Our aim is to discuss whether there is a relationship between the immunohistochemical presence of GH, FSH, LH, PRL, ACTH, TSH and their aggressive clinical course in non-functional pituitary adenomas. Materials and Methods In this study, we evaluated retrospectively the files of the patients who were diagnosed with thesellar or parasellar tumor in our endocrinology clinic between the years of 2004-2014.The patients were divided into two groups as non-invasive pituitary adenomas and non-functional invasive pituitary adenomas. The immunohistochemical staining characteristics were compared between the two groups. Results In this study, we scanned the data of 70 patients who were followed for non-functional sellar or parasellar mass. 47.1% of the patients were female and 52.9% of the patients were male.39 patients had a non-functional pituitary adenoma.The rate of non-functional invasive adenoma was found to be 20.5%. There was a significant relationship between the immunohistochemical positivity of GH, FSH, LH andaggressive behavior of non-functional invasive adenomas. There was no a significant relationship between the immunohistochemicalpositivityof PRL, ACTH, TSH and aggressive behavior of non-functional invasive adenomas. Conclusion We found silent GH and gonadotropin adenomas as non-functional aggressive pituitary adenoma. More aggressive treatment and close clinical monitoring should be performed because atypical pituitary adenomas are characterized by invasive growth and aggressive clinical course.

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