Invasive Growth Hormone Producing Pituitary Adenoma With Lymphocytic Infiltration: A Case Report and Literature Review

Abstract Background Functional gonadotroph adenomas (FGAs) are rare adenomas that most commonly secrete FSH. However, solitary LH-secreting pituitary adenomas are unusual. Case presentation A 30-year-old woman with elevated LH and normal FSH presented with inability to conceive. An MRI revealed an enlarged sella turcica and an intrasellar mass. Treatment with transsphenoidal resection led to normalization of LH and estradiol, as well as successful pregnancy. And we reviewed 6 cases of LH-secreting pituitary adenomas from 1981 to 2020. Conclusions Our case is unique because of the LH-secreting pituitary adenoma without FSH hypersecretion. This case indicates that pituitary adenoma should be considered when other diseases causing infertility have been excluded.

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Co-occurrence of mutations in KIF7 and KIAA0556 in Joubert syndrome with ocular coloboma, pituitary malformation and growth hormone deficiency: a case report and literature review

BMC Pediatrics ◽

10.1186/s12887-020-2019-0 ◽

2020 ◽

Vol 20 (1) ◽

Cited By ~ 2

Author(s):

Marcello Niceta ◽

Maria Lisa Dentici ◽

Andrea Ciolfi ◽

Romana Marini ◽

Sabina Barresi ◽

...

Keyword(s):

Growth Hormone ◽

Case Report ◽

Literature Review ◽

Growth Hormone Deficiency ◽

Joubert Syndrome ◽

Hormone Deficiency

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Pituitary Adenoma Confined Within the Pituitary Stalk: A Case Report and Literature Review

Journal of Neurointensive Care ◽

10.32587/jnic.2021.00416 ◽

2021 ◽

Vol 4 (2) ◽

pp. 76-80

Author(s):

Jae Hyun Park ◽

Tae Hoon Roh ◽

Jang-Hee Kim ◽

Se-Hyuk Kim

Keyword(s):

Case Report ◽

Pituitary Adenoma ◽

Literature Review ◽

Pituitary Stalk

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Aggressive pituitary adenoma in the context of Lynch syndrome: a case report and literature review on this rare coincidence

British Journal of Neurosurgery ◽

10.1080/02688697.2021.1967881 ◽

2021 ◽

pp. 1-6

Author(s):

Jan Teuber ◽

Annekathrin Reinhardt ◽

David Reuss ◽

Stefan Hähnel ◽

Andreas Unterberg ◽

...

Keyword(s):

Case Report ◽

Pituitary Adenoma ◽

Literature Review ◽

Lynch Syndrome

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Intracranial and intraspinal dissemination from a growth hormone-secreting pituitary tumor

Journal of Neurosurgery ◽

10.3171/jns.1986.64.1.0140 ◽

1986 ◽

Vol 64 (1) ◽

pp. 140-144 ◽

Cited By ~ 26

Author(s):

Nobuo Hashimoto ◽

Hajime Handa ◽

Shogo Nishi

Keyword(s):

Growth Hormone ◽

Cerebrospinal Fluid ◽

Radiation Therapy ◽

Pituitary Adenoma ◽

Pituitary Tumor ◽

Invasive Growth ◽

Metastatic Tumors ◽

Content Type ◽

Fine Print

✓ A 48-year-old woman developed multiple intracranial and intraspinal metastases from an invasive growth hormone-secreting pituitary adenoma after surgery and radiation therapy. This is the first reported case to show that the cells in the metastatic tumors and in the cerebrospinal fluid contained growth hormone.

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An interesting presentation of pituitary adenoma

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20194243 ◽

2019 ◽

Vol 6 (5) ◽

pp. 1684

Author(s):

Banupriya M. ◽

Jagadeesan M. ◽

Mariraj I. ◽

Prasanna Karthik S. ◽

Padmalatha D. ◽

...

Keyword(s):

Growth Hormone ◽

Case Report ◽

Pituitary Adenoma ◽

Growth Factor ◽

Magnetic Resonance ◽

Magnetic Resonance Image ◽

Endocrine Dysfunction ◽

Clinical Observations ◽

Hands And Feet ◽

The Brain

Pitutary adenomas are one of the commonest tumors of seller region of which prolactinomas and non- functioning adenomas predominate. The usual presentation are symptoms of endocrine dysfunction and mass effects. We present a case report of 37 year old male presenting with frontal headache and vomiting. Clinical observations revealed frontal bossing with enlarged hands and feet which arose a suspicion of Acromegaly. Investigations revealed elevated IGF 1 (insulin like growth factor) and growth hormone levels. Magnetic resonance image of the brain were done which showed pituitary adenoma. This case highlights the importance of clinical examination and the treating physician must have high clinical index of suspicion to detect endocrine dysfunction and use the modern techniques like stereotactic radio surgery (SRS).

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