scholarly journals New Approaches to Sample Preparation and Integrated Spectroscopic Methods for The Identification of Polioxyethylene Triolate Sorbitane for Pharmaceutical Examination of Drugs

2020 ◽  
pp. 181
Author(s):  
Yerbolat Orazbekuly ◽  
Gulzat Aitkaliyeva ◽  
Madeniyet Yelubay
Keyword(s):  
Sample Preparation ◽  
Research Methods ◽  
The United States ◽  
United States Pharmacopeia ◽  
Spectroscopic Methods ◽  
European Pharmacopoeia ◽  
Organic Impurities ◽  
Fast Pace ◽  
States Pharmacopeia ◽  
Complex Methods

Due to the fast pace of development of spectroscopic research methods in the pharmaceutical expertise of drugs presented in the United States Pharmacopeia (USP) and European Pharmacopoeia (Ph. Eur.), in this paper, we examined complex methods for the identification and preparation for analysis of polyethylene sorbitan trioleate. Two new systems were identified for purification of 98% polyoxyethylene sorbitan trioleate from organic impurities in column chromatography: acetonitrile 100% and acetonitrile/acetone 7.5/2.5. It was also revealed that a chamber with metallic iodine was the most suitable for selecting an eluent and controlling the cleaning by the TLC method. Proton NMR did not detect organic impurities. Identification of polyoxyethylene sorbitan trioleate was carried out on H1, C13, COSY, and IR spectra. These research methods are characterized by simplicity in sample preparation, the availability of reagents, the effectiveness of identification and quantification analyzes, and the efficiency in labor and material costs

A Comparison of Heparin Potency Estimates Obtained by Activated Partial Thromboplastin Time and British Pharmacopoeial Assays

1985 ◽  
Vol 53 (01) ◽  
pp. 116-117 ◽  
Author(s):  
R E Merton ◽  
A D Curtis ◽  
D P Thomas
Keyword(s):  
United States ◽  
Partial Thromboplastin Time ◽  
Close Agreement ◽  
The United States ◽  
Activated Partial Thromboplastin Time ◽  
United States Pharmacopeia ◽  
International Unit ◽  
British Pharmacopoeia ◽  
States Pharmacopeia ◽  
Heparin Preparation

SummaryHeparin samples from five manufacturers were assayed by the revised British Pharmacopoeia (BP) heparin assay and the results compared with those obtained using the activated partial thromboplastin time (APTT) assay. The United States Pharmacopeia (USP) reference heparin preparation and the 4th International Standard (IS) for heparin were also assayed by the two methods relative to the 3rd IS. The results obtained by the revised BP assay were in close agreement with those obtained by the APTT assay for all the heparins that were tested. The assays revealed that there is at least a 10% discrepancy between the International Unit for heparin and the USP unit.

Quantitative Procedure for CWorophyllin Copper Complex

1994 ◽  
Vol 77 (3) ◽  
pp. 756-757 ◽  
Author(s):  
Simon Chernomorsky
Keyword(s):  
United States ◽  
Elemental Analysis ◽  
Copper Complex ◽  
Comparative Studies ◽  
Copper Content ◽  
The United States ◽  
United States Pharmacopeia ◽  
Optical Measurements ◽  
States Pharmacopeia ◽  
Quantitative Procedure

Abstract The reliability of the currently used quantitative assay for commercially available chlorophyllin copper complex is discussed. It was shown that optical measurements at 405 nm can overestimate the purity of the preparation by 16.4–49.5%. This conclusion is from comparative studies using spectrophotometry at 405 nm and elemental analysis (copper content) of chlorophyllin copper complex. Spectrophotometry at 630 nm resulted in closer agreement with data calculated from elemental analysis. These observations have to be taken into consideration by those involved in the manufacture and distribution of chlorophyllin copper complex as well as in the development of the United States Pharmacopeia compendial monograph for this preparation.

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