scholarly journals Clinical Features and Outcomes of IgA Nephropathy with Nephrotic Syndrome

2012 ◽  
Vol 7 (3) ◽  
pp. 427-436 ◽  
Author(s):  
Jwa-Kyung Kim ◽  
Jeong Ho Kim ◽  
Sang Choel Lee ◽  
Ea Wha Kang ◽  
Tae Ik Chang ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Iga Nephropathy ◽  
Clinical Features

Mesangial IgA Nephropathy and Idiopathic Nephrotic Syndrome

Nephron ◽  
1987 ◽  
Vol 47 (3) ◽  
pp. 190-193 ◽  
Author(s):  
M. Rambausek ◽  
R. Waldherr ◽  
W. Rauterberg ◽  
K. Andrassy ◽  
E. Ritz
Keyword(s):  
Nephrotic Syndrome ◽  
Iga Nephropathy ◽  
Idiopathic Nephrotic Syndrome

scholarly journals Indian scenario of IgA nephropathy: a systematic review and meta-analysis

2021 ◽  
Vol 21 (1) ◽  
pp. 159-65
Author(s):  
Anju Khairwa
Keyword(s):  
Systematic Review ◽  
Iga Nephropathy ◽  
Clinical Features ◽  
Meta Analysis ◽  
Microscopic Hematuria ◽  
Macroscopic Hematuria ◽  
Female Ratio ◽  
Cochrane Database ◽  
Male Female Ratio ◽  
Indian Scenario

Background: IgA nephropathy (IgAN) is most common primary glomerulopathy. There are variations in prevalence of IgAN and its clinical features in different studies from India. Aim: To summarize overall scenario of IgAN in India. Methods: In this systematic review, studies related to IgAN and related renal disease were included. Data searched were PubMed, EMBASE, Google scholar, and Cochrane Database from inception to 31st January 2019. Results: Total 49 studies (N=2480) were included: 21studies (N=2309) of primary IgAN; 19 studies (N=21) of Secondary IgAN; four studies (N=133) of IgA vasculitis nephropathy (IgAVN); and five studies (N=17) of IgA dominant nephropathy (IgADN). Prevalence of IgAN was 16.5% in India. Age of affected persons was ranging from 27.2±16.7 to 48.6±21.3 years . Male female ratio was 1.8:1. Clinical features of Primary IgAN, IgAVN, IgADN & Secondary IgAN were microscopic hematuria (49.6%, 44.4%, 15.6% & 59.5%), macroscopic hematuria (5.1%, 0.4%,40.9%,& 35.7%), Subnephrotic proteinuria (42.1%, 29.4%, 23.2%, & 52.3%), nephrotic proteinuria (16.0%, 4.4%, 76.8%,& 47.6%), and hypertension (25.8%,18.3%, 35.5%,& 47.6%).. The 24 hours proteinuria was ranging from 2.6±1.5 to 4.7±2.3 gm/day and serum creatinine (mg/dl) was ranging from 0.9±0 to 3.5±3.9 mg/dl. Histolomorphologically, all type of IgAN showed mesangial hypercellularity and Immunofluorescence revealed IgA deposition. Conclusion: The overall prevalence of primary IgAN in India was 16.5%. The subnephrotic proteinuria and microscopic hematuria were common clinical features. Keywords: IgA Nephropathy; histomorphology; prevalence; India.

MO294COMPARISON OF TIP AND CELLULAR VARIANT OF PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Nikola Zagorec ◽  
Ivica Horvatić ◽  
Dino Kasumović ◽  
Petar Šenjug ◽  
Matija Horaček ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Focal Segmental Glomerulosclerosis ◽  
Clinical Features ◽  
Remission Rate ◽  
Prognostic Significance ◽  
European Population ◽  
University Hospital ◽  
Outcome Analysis ◽  
Laboratory Findings ◽  
Segmental Glomerulosclerosis

Abstract Background and Aims After membranous nephropathy, focal segmental glomerulosclerosis (FSGS) is the most common cause of nephrotic syndrome in European population. According to Columbia classification, there are five histological variants of FSGS defined on light microscopy (tip, cellular, perihilar, collapsing and not otherwise specified - NOS) and this classification has a prognostic significance. The aim is to compare features and outcomes of tip and cellular variant of primary FSGS. Method All patients with FSGS were identified by a retrospective review of the Registry of kidney biopsies at the Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, from 2003 until 2020. Each kidney specimen was analyzed by light, immunofluorescent and electron microscopy and Columbia classification was applied by experienced nephropathologist. Patients with primary FSGS met following criteria: full nephrotic syndrome and diffuse podocyte foot process effacement in absence of secondary causes of FSGS. Laboratory findings were obtained for every patient at the time of biopsy and following outpatient visits. Complete remission was defined as proteinuria < 0.3 g/day with normal kidney function and partial remission as proteinuria 0.3 - 3.5 g/day. Variables are expressed as median ± IQR (interquartile range) and frequencies. Statistical comparison between groups of patients with tip and cellular variant of primary FSGS and disease outcome analysis were done. Results Out of 200 patients with FSGS, 59 (29.5 %) had primary form of disease. Tip variant was the most common form of primary FSGS (22 patients, 37 %) followed by NOS (20, 34 %), cellular (13, 22 %), perihilar (2, 3.5 %) and collapsing (2, 3.5 %) variant. Demographic and clinical features with initial laboratory findings are shown in Table 1. There were no significant differences between two groups in all analyzed variables in Figure 1. All patients were treated by anti-RAAS agents and steroids. Median follow-up was 55 months (range 1 – 196 months), and followup data were unavailable for three patients. Figure 2 shows treatment regimens in both patient grouos with treatment outcomes. Remission rate was significantly higher in tip variant (90 % vs. 41 %, p = 0.002). There was no difference in relapse rate between the two groups (p = 0.717). Conclusion There were no significant differences in clinical features and laboratory findings at the time of clinical presentation between tip and cellular variant of primary FSGS. Patients with tip variant had significantly higher remission rate than patients with cellular variant.

A Patient with IgA Nephropathy: 5 Years after Complete Remission of Minimal Change Nephrotic Syndrome

2016 ◽  
Vol 39 (4) ◽  
pp. 118 ◽  
Author(s):  
Ji Won Kim ◽  
Jun Hyung Park ◽  
Da Hee Kim ◽  
Hyung Young Kim ◽  
Sang Hyun Kim ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Complete Remission ◽  
Iga Nephropathy ◽  
Minimal Change Nephrotic Syndrome ◽  
Minimal Change

scholarly journals Clinicopathologic Characteristics of IgA Nephropathy with Steroid-responsive Nephrotic Syndrome

2009 ◽  
Vol 24 (Suppl 1) ◽  
pp. S44 ◽  
Author(s):  
Sun Moon Kim ◽  
Kyung Chul Moon ◽  
Kook-Hwan Oh ◽  
Kwon Wook Joo ◽  
Yon Su Kim ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Iga Nephropathy ◽  
Clinicopathologic Characteristics

Pediatric IgA nephropathy: clinical features at presentation and outcome for African-Americans and Caucasians

2004 ◽  
Vol 62 (09) ◽  
pp. 167-172 ◽  
Author(s):  
K.K. Lau ◽  
L.W. Gaber ◽  
N.M. Delos Santos ◽  
K.A. Fisher ◽  
S.J. Grimes ◽  
...  
Keyword(s):  
African Americans ◽  
Iga Nephropathy ◽  
Clinical Features

scholarly journals Spectrum of Biopsy Proven Glomerular Disease in Children at Kanti Children’s Hospital

2015 ◽  
Vol 34 (3) ◽  
pp. 225-229 ◽  
Author(s):  
N Khatun ◽  
KP Bista ◽  
C Mahaseth
Keyword(s):  
Nephrotic Syndrome ◽  
Lupus Nephritis ◽  
Renal Disease ◽  
Iga Nephropathy ◽  
Kidney Biopsy ◽  
Demographic Data ◽  
Glomerular Disease ◽  
Children's Hospital ◽  
Steroid Dependent ◽  
Children’S Hospital

Introduction: Glomerular disease is one of the most common forms of renal disease and can have many different clinical presentations. However there is variation in the prevalence in the type of glomerular disease according to geographical location and race of population. The aim of the study was to find the overall distribution pattern of glomerular disease based on renal biopsies. Material and Methods: The medical records of all children who underwent kidney biopsy (n=29) between January 2012-june 2014 were analyzed. In this retrospective study we review children from Kanti Children’s Hospital, Nephrology Department. Demographic data including age, sex and indication of kidney biopsy as well as complication of the procedures were recorded. Result: A total number of thirty one biopsies were done. Two children were excluded from the study due to inadequate tissue and artifacts defects in preservative. The remaining twenty nine biopsies were included in the study and analyzed. Renal disease was found nearly equal in both male and female (51.72% vs. 48.27%).Mean age was 10.95±3.30 years. Maximum number of biopsies (75.86%) was performed between 10- 15 years. The most common indication of the kidney biopsy was nephrotic syndrome (steroid resistant nephrotic syndrome and steroid dependent nephrotic syndrome, 31.02% followed by lupus nephritis 27.58%.The most common glomerular disease were focal segmental glomerulosclerosis and lupus nephritis both contribute 27.58%. Among lupus nephritis class III was found more common (44.44%) in children. IgA nephropathy was also contribute (17.24%) in all glomerular disease. Regarding the kidney biopsy complication gross hematuria was observed in 6.89% of children which was self-limited. Conclusion: FSGS and lupus nephritis is becoming the most common glomerular disease in children attending the Kanti Children Hospital. IgA nephropathy was also contribute the glomerular disease in the children. J Nepal Paediatr Soc 2014;34(3):225-229   DOI: http://dx.doi.org/10.3126/jnps.v34i3.11162  

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