In silico modeling of cellular probabilistic nanoparticle radiosensitization in head and neck cancers

Background: The use of gold nanoparticles (AuNPs) as radiosensitizers may offer a new approach in the treatment of head and neck cancers; minimizing treatment-associated toxicities and improving patient outcomes. AuNPs promote localized dose deposition; permitting improved local control and/or dose reduction. Aim: This work aimed to address the theoretical optimization of radiation doses, fractionation and nanoparticle injection schedules to maximize therapeutic benefits. Materials & methods: Probabilistic nanoparticle sensitization factors were incorporated into the individual cell-based HYP-RT computer model of tumor growth and radiotherapy. Results: Total dose outcomes across all radiation therapy treatment regimens were found to be significantly reduced with the presence of AuNPs, with bi-weekly injections showing the most decrease. Conclusion: Outcomes suggest the need for regular AuNP administration to permit effective radiosensitization.

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Patient Generated Index in HIV Chemosensory & auditory complaints: An observational study

10.14293/s2199-1006.1.sor-.pp5omsw.v1 ◽

2020 ◽

Author(s):

Usama Fawzy Kamel ◽

Ushan Andrady

Keyword(s):

Hiv Positive ◽

Exclusion Criteria ◽

New Approach ◽

Patient Generated Index ◽

Chemosensory Perception ◽

Observational Cohort ◽

Areas Of Concern ◽

The Individual ◽

Therapy Treatment

HIV is a chronic manageable disease. The disease and/or antiretroviral therapy treatment may lead to patient complaints regarding their hearing and chemosensory perception. Patient Generated Index (PGI) has been a validated patient generated questionnaire, which is flexible to capture areas relevant to patients [i] . It has not been used before to assess the chemosensory (smell and taste) and auditory concerns of HIV positive patients. Methods: PGI questionnaire was distributed to nineteen HIV patients attending the research clinic. Patients had five areas to record their perception in relation to senses (smell, taste and hearing). They then score how do they feel about this particular area, then they spend points to improve the area when needed. Patients were recruited from a HIV clinic after giving their informed consent matching inclusion/exclusion criteria. The questionnaire had five sections where patients identify problems matter to them in relation to smell, taste and hearing. The sixth question is generated by the patient in relation to other health areas of concern to the individual. Results: PGI scores (n=19) mean was 5.39 (range 1.08 8, SD 1.93). Smell mean scores 1.1, taste was 1 and hearing was 0.97 Smell was 20.4% of the total PGI score; taste was 18.6% and hearing 18% of the PGI score. Patients scored 2.32 (43% of the total PGI score) in other areas (back pain, arthritis, stomach pains, ) Conclusions: This is an observational cohort study to document the PGI results in relation to auditory and chemosensory perception in HIV positive patients. Although auditory and chemosensory problems in five areas scores altogether 57% of the PGI score, others (one area question), patients scored 43% of the total PGI score. Other complaints preoccupied patients and were relatively more cumbersome than the three senses. [i] Ruta D, Garratt A, Leng M, Russell I, MacDonald L. A New Approach to the Measurement of Quality of Life: The Patient-Generated Index. Medical Care. 1994 Nov;32(11):1109-1126

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