A simple strategy increases mothers’ knowledge of breastfeeding and improves the breastfeeding rates

1998 ◽  
Vol 74 (5) ◽  
pp. 368-76 ◽  
Author(s):  
Lulie R.O. Susin ◽  
Elsa R. J. Giugliani ◽  
Suzane C. Kummer ◽  
Marileide Maciel ◽  
Ana C. W. Benjamin ◽  
...  
Keyword(s):  
Simple Strategy ◽  
Breastfeeding Rates

A simple strategy for fabricating honeycomb patterns on commercially available polymer film under a wide humidity range

2020 ◽  
Vol 35 (23-24) ◽  
pp. 3210-3221
Author(s):  
Kai Huang ◽  
Qi Cheng ◽  
Honglei Zhang ◽  
Ligang Lin ◽  
Qiying Wang
Keyword(s):  
Polymer Film ◽  
Simple Strategy ◽  
Humidity Range

Abstract

Hierarchy of π-Stacking Determines the Conformational Preference of Bis-Squaraines

2020 ◽  
Author(s):  
Abhishek Singh ◽  
Reman K. Singh ◽  
G Naresh Patwari
Keyword(s):  
Hydrogen Bonding ◽  
Rational Design ◽  
Biological Molecules ◽  
Conformational Space ◽  
X Ray Crystallography ◽  
Simple Strategy ◽  
Induced Folding ◽  
Π Stacking ◽  
Varying Length ◽  
Dynamics Simulations

The rational design of conformationally controlled foldable modules can lead to a deeper insight into the conformational space of complex biological molecules where non-covalent interactions such as hydrogen bonding and π-stacking are known to play a pivotal role. Squaramides are known to have excellent hydrogen bonding capabilities and hence, are ideal molecules for designing foldable modules that can mimic the secondary structures of bio-molecules. The π-stacking induced folding of bis-squaraines tethered using aliphatic primary and secondary-diamine linkers of varying length is explored with a simple strategy of invoking small perturbations involving the length linkers and degree of substitution. Solution phase NMR investigations in combination with molecular dynamics simulations suggest that bis-squaraines predominantly exist as extended conformations. Structures elucidated by X-ray crystallography confirmed a variety of folded and extended secondary conformations including hairpin turns and 𝛽-sheets which are determined by the hierarchy of π-stacking relative to N–H···O hydrogen bonds.

Hierarchy of π-Stacking Determines the Conformational Preference of Bis-Squaraines

2020 ◽  
Author(s):  
Abhishek Singh ◽  
Reman K. Singh ◽  
G Naresh Patwari
Keyword(s):  
Hydrogen Bonding ◽  
Rational Design ◽  
Biological Molecules ◽  
Conformational Space ◽  
X Ray Crystallography ◽  
Simple Strategy ◽  
Induced Folding ◽  
Π Stacking ◽  
Varying Length ◽  
Dynamics Simulations

The rational design of conformationally controlled foldable modules can lead to a deeper insight into the conformational space of complex biological molecules where non-covalent interactions such as hydrogen bonding and π-stacking are known to play a pivotal role. Squaramides are known to have excellent hydrogen bonding capabilities and hence, are ideal molecules for designing foldable modules that can mimic the secondary structures of bio-molecules. The π-stacking induced folding of bis-squaraines tethered using aliphatic primary and secondary-diamine linkers of varying length is explored with a simple strategy of invoking small perturbations involving the length linkers and degree of substitution. Solution phase NMR investigations in combination with molecular dynamics simulations suggest that bis-squaraines predominantly exist as extended conformations. Structures elucidated by X-ray crystallography confirmed a variety of folded and extended secondary conformations including hairpin turns and 𝛽-sheets which are determined by the hierarchy of π-stacking relative to N–H···O hydrogen bonds.

Revealing changes in curcumin bioavailability using vitamin C as an enhancer by HPLC-MS/MS

2019 ◽  
Vol 16 ◽  
Author(s):  
Xufen Dai ◽  
Jiaxue Hao ◽  
Ying Feng ◽  
Jing Wang ◽  
Qiannan Li ◽  
...  
Keyword(s):  
Vitamin C ◽  
High Performance ◽  
Internal Standard ◽  
Fold Increase ◽  
Rat Plasma ◽  
Pharmacokinetic Parameters ◽  
Solution Ph ◽  
Esi Ms ◽  
Simple Strategy ◽  
Isolated Compound

Background: Curcumin (CUR), a natural isolated compound from turmeric, has been the promising star in fighting many diseases but the broad application of curcumin has been limited ascribed to low bioavailability. Objective: The aim of this study is to pursue the enhancement of curcumin bioavailability through co-administration of vitamin C. Methods: Such purpose was achieved through the analysis of curcumin pharmacokinetics by high performance liquid chromatography coupled with electrospray ionization - tandem mass spectrometry (HPLC - ESI - MS/MS). The plasma was separated on a C18 reverse phase column using acetonitrile and ammonium formate solution (pH 6.5; 2.0 mM) at 0.8 mL/min. MS/MS detection was carried out in negative mode using mass patterns of m/z 367.0 > 216.7 for curcumin and m/z 265.2 > 223.9 for internal standard (honokiol). Results: Successful application of the proposed method in the pharmacokinetic study presented clear changes in key pharmacokinetic parameters including the growth of AUC (0-t) up to 2.4 times, 2.2-fold increase of Cmax, 2.2-fold loss of CL, and 1.5-fold diminishment of t1/2. Conclusion: We developed an HPLC-ESI-MS/MS method for determination of curcumin in rat plasma and validated the improvement of bioavailability of curcumin through co-administration of vitamin C. We reasoned these changes to the inhibition of lipid peroxidation induced by the use of vitamin C. Such a simple strategy is possible to become an alternative for enhancing curcumin efficiency in practice.

A simple strategy based on photobiotin irradiation for the photoelectrochemical immobilization of proteins on electrode surfaces

2006 ◽  
Vol 26 (2-3) ◽  
pp. 436-441 ◽  
Author(s):  
Serge Cosnier ◽  
Carmen Molins ◽  
Christine Mousty ◽  
Bruno Galland ◽  
Arielle Lepellec
Keyword(s):  
Electrode Surfaces ◽  
Simple Strategy

1126 Breastfeeding rates in women that attempt trial of labor after cesarean vs. repeat cesarean delivery

2021 ◽  
Vol 224 (2) ◽  
pp. S694
Author(s):  
Kerly M. Guerrero ◽  
Reshma Parikh ◽  
Eve Swirski ◽  
Kaila Krishnamoorthy ◽  
Lisa Gittens ◽  
...  
Keyword(s):  
Cesarean Delivery ◽  
Trial Of Labor ◽  
Breastfeeding Rates ◽  
Repeat Cesarean Delivery

scholarly journals A Novel Quinoxaline-Rhodamine Conjugate for a Simple and Efficient Detection of Hydrogen Sulphate Ion

Compounds ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 29-40
Author(s):  
Sutapa Sahu ◽  
Yeasin Sikdar ◽  
Riya Bag ◽  
Dilip K. Maiti ◽  
José P. Cerón-Carrasco ◽  
...  
Keyword(s):  
Solid Phase ◽  
Detection Limits ◽  
Hydrogen Sulfate ◽  
Absorption And Emission ◽  
Conjugate System ◽  
Colorimetric Chemosensor ◽  
Simple Strategy ◽  
Efficient Detection ◽  
Hydrogen Sulphate

This work presents the development of a quinoxaline and rhodamine conjugate system that acts as a colorimetric chemosensor for hydrogen sulfate (HSO4−) ions in methanol media. This sensor has been characterized both theoretically and experimentally. The detection limits for HSO4− are small as 0.71 µM and 3.8 µM for the absorption and emission experiments, respectively. The effectiveness of the probe in recognizing HSO4− both in gel and solid phase is evaluated as well. Thus, this works presents a simple strategy to detect the environmental HSO4− pollutant event at tiny concentrations.

scholarly journals Cyclometalated iridium–BODIPY ratiometric O2 sensors

2019 ◽  
Vol 10 (19) ◽  
pp. 5124-5132 ◽  
Author(s):  
Ku Sun Choung ◽  
Karen Marroquin ◽  
Thomas S. Teets
Keyword(s):  
Molecular Oxygen ◽  
Simple Strategy ◽  
Ratiometric Sensors

Cyclometalated iridium–BODIPY conjugates are prepared by a simple strategy and are effective ratiometric sensors for molecular oxygen.

-ADIC -FUNCTIONS FOR ORDINARY FAMILIES ON SYMPLECTIC GROUPS

2019 ◽  
Vol 19 (4) ◽  
pp. 1287-1347 ◽  
Author(s):  
Zheng Liu
Keyword(s):  
Eisenstein Series ◽  
Symplectic Group ◽  
Symplectic Groups ◽  
Simple Strategy ◽  
Doubling Method

We construct the $p$-adic standard $L$-functions for ordinary families of Hecke eigensystems of the symplectic group $\operatorname{Sp}(2n)_{/\mathbb{Q}}$ using the doubling method. We explain a clear and simple strategy of choosing the local sections for the Siegel Eisenstein series on the doubling group $\operatorname{Sp}(4n)_{/\mathbb{Q}}$, which guarantees the nonvanishing of local zeta integrals and allows us to $p$-adically interpolate the restrictions of the Siegel Eisenstein series to $\operatorname{Sp}(2n)_{/\mathbb{Q}}\times \operatorname{Sp}(2n)_{/\mathbb{Q}}$.

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