Assessment of calcium and phosphate homeostasis in chronic kidney disease

2017 ◽  
pp. 143-150
Author(s):  
Rebecca Geddes ◽  
Jonathan Elliott
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Phosphate Homeostasis

Regulation and Effects of FGF23 in Chronic Kidney Disease

2020 ◽  
Vol 82 (1) ◽  
pp. 365-390 ◽  
Author(s):  
John Musgrove ◽  
Myles Wolf
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Mineral Metabolism ◽  
Fibroblast Growth Factor 23 ◽  
Premature Death ◽  
Hypophosphatemic Rickets ◽  
Paradigm Shifts ◽  
Phosphate Homeostasis ◽  
Increase Risk ◽  
Hereditary Disorders

Chronic kidney disease (CKD) is a global health epidemic that accelerates cardiovascular disease, increases risk of infection, and causes anemia and bone disease, among other complications that collectively increase risk of premature death. Alterations in calcium and phosphate homeostasis have long been considered nontraditional risk factors for many of the most morbid outcomes of CKD. The discovery of fibroblast growth factor 23 (FGF23), which revolutionized the diagnosis and treatment of rare hereditary disorders of FGF23 excess that cause hypophosphatemic rickets, has also driven major paradigm shifts in our understanding of the pathophysiology and downstream end-organ complications of disordered mineral metabolism in CKD. As research of FGF23 in CKD has rapidly advanced, major new questions about its regulation and effects continuously emerge. These are promoting exciting innovations in laboratory, patient-oriented, and epidemiological research and stimulating clinical trials of new therapies and repurposing of existing ones to target FGF23.

scholarly journals SP370FGF23 MAINLY REGULATES PHOSPHATE HOMEOSTASIS IN STAGE 3 CHRONIC KIDNEY DISEASE

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii236-iii237
Author(s):  
Takaaki Kimura ◽  
Kazuhiro Shiizaki ◽  
Akira Kurosawa ◽  
Toshihiro Shimizu ◽  
Takahiro Shinzato ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Phosphate Homeostasis
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