scholarly journals SIGNET RING CELL CARCINOMA PADA PAYUDARA

2015 ◽  
Vol 37 (2) ◽  
pp. 162
Author(s):  
Muhartono Muhartono
Keyword(s):  
Cell Carcinoma ◽  
Needle Aspiration ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Architectural Distortion ◽  
Signet Ring ◽  
Cancer Types ◽  
Ring Cell ◽  
Needle Aspiration Cytology ◽  
Common Malignancy

AbstrakKanker payudara merupakan keganasan yang paling sering ditemukan pada wanita. Kanker payudara jenis signet ring cell carcinoma (SRCC) sangat jarang ditemukan. Kasus SRCC paling banyak ditemukan pada saluran cerna (GIT). Dilaporkan kasus, wanita 46 tahun, terdapat benjolan di payudara. Pemeriksaan ultrasonografi payudara menunjukkan area hypoechoik. Mamografi menunjukkan payudara heterogen padat, distorsi arsitektur atau mikrokalsifikasi. Aspirasi jarum halus sitologi dari jaringan payudara menunjukkan bahwa tumor adalah ganas. Pada pemeriksaan endoskopi gastrointestinal normal. Pemeriksaan Patologi menunjukkan sel-sel neoplastik bentuk bulat, tersebar atau distribusi disertai musin intrasitoplasmik besar menekan inti menuju salah satu kutub sel. Secara klinis, usg, maupun endoskopi tidak ditemukan massa tumor pada GIT. Pada pemeriksaan imunohistokimia SRCC payudara GCDFP15+, ER+, CK7+, MUC1+, CK20-, MUC2- dan SRCC GIT CK20+, MUC2+, GCDFP15-, ER-, CK7-, MUC1-, Simpulan, SRCC payudara adalah tumor ganas yang sangat langka dan harus dibedakan dari metastasis GIT.AbstractBreast cancer is the most common malignancy in women. Breast cancer types signet ring cell carcinoma (SRCC) is very rare. SRCC case most commonly found in the saluran cerna (GIT). Reported cases, female 46 years, there is a lump in the breast. Breast ultrasound examination showed hypoechoic area. Mammography showed heterogeneous dense breasts, architectural distortion or microcalcifications. Fine-needle aspiration cytology (FNAC) of the breast tissue showed that the tumor was malignant. In normal gastrointestinal endoscopy. Pathologic examination menunjukkan neoplastic cells rounded shape, spread or distribution with large intracytoplasmik mucin core pressing toward one pole of the cell. Clinically, ultrasound, and endoscopy was not found in the GIT tumor mass. On immunohistochemical examination breast SRCC on ER+, CK7+, MUC1+, MUC2-, CK20-; GIT SRCC CK20+, MUC2+, ER-, CK7-, MUC1-. Conclusion, breast SRCC is a malignant tumor that is very rare and should be differentiated from metastatic GIT.

scholarly journals Primary Signet Ring Cell Carcinoma of the Lung: A Rare Finding on Fine Needle Aspiration

2014 ◽  
Vol 142 (suppl_1) ◽  
pp. A064-A064
Author(s):  
Elina Shustef ◽  
Jose Mantilla ◽  
Esther Adler ◽  
Laleh Hakima ◽  
Samer Khader
Keyword(s):  
Cell Carcinoma ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Rare Finding ◽  
Fine Needle ◽  
Signet Ring ◽  
Ring Cell

A case of signet-ring cell carcinoma diagnosed by fine-needle aspiration breast cytology

2010 ◽  
Vol 49 (4) ◽  
pp. 268-272
Author(s):  
Mitsuhiro TACHIBANA ◽  
Yumi HASHIMOTO ◽  
Naoki OOISHI ◽  
Tamae SONE ◽  
Tatsuo UENO
Keyword(s):  
Cell Carcinoma ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Fine Needle ◽  
Signet Ring ◽  
Ring Cell

scholarly journals Primary signet‐ring cell carcinoma of the lung in an HIV‐positive patient

2021 ◽  
Vol 12 (7) ◽  
pp. 1122-1125
Author(s):  
Alberto Testori ◽  
Gianluca Perroni ◽  
Camilla De Carlo ◽  
Alessandro Crepaldi ◽  
Marco Alloisio ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Positive Patient ◽  
Hiv Positive ◽  
Signet Ring ◽  
Ring Cell

scholarly journals Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Somatic Mutations in CDH1 and Other Clinically Actionable Mutations Imply Early Use of Targeted Agents

2021 ◽  
Vol 28 (1) ◽  
pp. 918-927
Author(s):  
Lei-Chi Wang ◽  
Tai-Chi Lin ◽  
Yi-Chen Yeh ◽  
Hsiang-Ling Ho ◽  
Chieh-Chih Tsai ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Cell Carcinoma ◽  
Tumor Tissue ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Next Generation ◽  
Signet Ring ◽  
Ring Cell ◽  
Generation Sequencing ◽  
E Cadherin

Primary signet ring cell/histiocytoid carcinoma of the eyelid is a rare ocular malignancy and its diagnosis is often delayed. This neoplasm presents as an insidious, diffusely infiltrative mass in the periocular area that later infiltrates the orbit. An exenteration is usually indicated; however, nearly one-third of patients develop local recurrence or metastasis. Morphologically, it resembles signet ring cell carcinoma of the stomach and breast, raising the possibility of mutations in CDH1, the gene encoding E-cadherin. To determine whether primary signet ring cell/histiocytoid carcinoma harbors the CDH1 mutation or other actionable mutations, we analyzed the tumor tissue via next-generation sequencing. We identified only one case of primary signet ring cell carcinoma of the eyelid with adequate DNA quality for sequencing from the pathological archive during the period 2000 to 2020. A comprehensive evaluation including histopathology, immunohistochemistry, and next-generation sequencing assay was performed on tumor tissue. Immunohistochemically, the tumor exhibited E-cadherin membranous staining with the aberrant cytoplasmic staining of β-catenin. Using next-generation sequencing, we demonstrated the mutation in the CDH1 gene. In addition, other clinically actionable mutations including ERBB2 and PIK3CA were also detected. The alterations in other actionable genes indicate a need for larger studies to evaluate the pathogenesis and potential therapies for primary signet ring cell/histiocytoid carcinoma of the eyelid.

Fundic Gland Polyp With Parietal Cell Vacuolation Mimicking Signet Ring Cell Carcinoma

2021 ◽  
pp. 106689692199418
Author(s):  
John D. Coyne ◽  
S. Thampy
Keyword(s):  
Proton Pump Inhibitor ◽  
Cell Carcinoma ◽  
Parietal Cell ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Fundic Gland ◽  
Fundic Gland Polyp ◽  
Signet Ring ◽  
Ring Cell

Pseudo-signet ring parietal cell vacuolation has been described as a mimic of invasive signet ring cell carcinoma. Moreover, signet ring cell carcinoma has been described in a fundic gland polyp. This case demonstrates parietal cell vacuolation in a fundic gland polyp in a patient on a long-term proton pump inhibitor.

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