scholarly journals Prevalence of Some Gene Polymorphisms Related to Early Pregnancy Loss among Russian Women

2019 ◽  
Vol 23 (4) ◽  
pp. 381-389
Author(s):  
A. A. M. Ahmed ◽  
A. A. Muradian ◽  
M. M. Azova
Keyword(s):  
Early Pregnancy ◽  
Gene Polymorphisms ◽  
Pregnancy Loss ◽  
Previous History ◽  
Normal Pregnancy ◽  
Early Pregnancy Loss ◽  
Specific Pcr ◽  
Genetic Predictors ◽  
History Of ◽  
Allele Specific

Background. A variety of biological processes regulated by differential gene expression are required to maintain a normal gestation and accordingly, the mutations and polymorphisms in such genes may cause miscellaneous biological disorders that eventually result in early pregnancy loss. Many studies reported that aberrant fetal DNA methylation as well as embryonic chromosome abnormalities may lead to impairment of fetal early growth and development. Therefore, we have aimed to genotype several gene polymorphisms might be involved in the above-mentioned biological disorders to screen their prevalence in Russian population. Materials and methods. 81 Russian women without previous history of normal pregnancy or early abortion were recruited into this population study to determine the genotype and allele frequencies through genotyping using RFLP-PCR method for DNMT3B rs2424913, DNMT3B rs1569686, DNMT3A rs7590760, DNMT1 rs2228611, DNMT1 rs8101626, DNMT3L rs2276248, and DNMT3L rs2070565, allele-specific PCR for SYCP3 T657C, and real-time PCR for MTHFR rs1801133, MTHFR rs1801131, MTR rs1805087, and MTRR rs1801394. Results. Minor homozygous genotypes and minor alleles of the polymorphisms DNMT3B rs2424913 (TT: 11.1%, T: 37.05%), DNMT1 rs2228611 (GG: 18.5%, G: 40.75%), and DNMT1 rs8101626 (GG: 16.0%, G: 40.1%) were quite prevalent in Russian women and as frequent as those of the well-studied polymorphisms: MTRR rs1801394 (GG: 27.2%, G: 50.65%), MTHFR rs1801131 (CC: 17.3%, C: 40.15%), and MTHFR rs1801133 (TT: 11.1%, T: 29.0%).The heterozygous genotype of SYCP3 T657C (CT: 12.3%, T: 6.15%) was also quite frequent. Conclusion. Based on our study and literature data, we suggest that DNMT3B rs2424913, DNMT1 rs2228611, DNMT1 rs8101626, and SYCP3 T657C polymorphisms along with the common folate cycle gene polymorphisms can be potential genetic predictors for early pregnancy loss in Russian women.

Cytokine gene polymorphisms and early pregnancy loss

2015 ◽  
Vol 5 (5) ◽  
pp. 500-506
Author(s):  
E. V. Mashkina ◽  
K. A. Kovalenko ◽  
N. V. Fomina ◽  
T. P. Shkurat
Keyword(s):  
Early Pregnancy ◽  
Gene Polymorphisms ◽  
Pregnancy Loss ◽  
Early Pregnancy Loss ◽  
Cytokine Gene ◽  
Cytokine Gene Polymorphisms

DNMT1 and DNMT3A Gene Polymorphisms and Early Pregnancy Loss

2020 ◽  
Vol 56 (3) ◽  
pp. 379-382
Author(s):  
A. A. M. Ahmed ◽  
M. M. Azova ◽  
F. U. Ramazanova ◽  
O. B. Gigani
Keyword(s):  
Early Pregnancy ◽  
Gene Polymorphisms ◽  
Pregnancy Loss ◽  
Early Pregnancy Loss

Recurrent early pregnancy loss and endothelial nitric oxide synthase gene polymorphisms

2005 ◽  
Vol 274 (2) ◽  
pp. 119-124 ◽  
Author(s):  
Venkata Suryanarayana ◽  
Lakshmi Rao ◽  
Murthy Kanakavalli ◽  
Venkata Padmalatha ◽  
Mamata Deenadayal ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Early Pregnancy ◽  
Endothelial Nitric Oxide Synthase ◽  
Gene Polymorphisms ◽  
Pregnancy Loss ◽  
Early Pregnancy Loss ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Recurrent Early Pregnancy Loss

scholarly journals Role of human chorionic gonadotrophin to prevent repeated early pregnancy loss

2016 ◽  
Vol 48 (1-2) ◽  
pp. 7-10
Author(s):  
Eti Saha ◽  
Fouzia Begum ◽  
Zannatul Ferdous Jesmin
Keyword(s):  
Early Pregnancy ◽  
Pregnancy Loss ◽  
First Trimester ◽  
Additional Treatment ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Early Pregnancy Loss ◽  
Significant Difference ◽  
Improve Pregnancy Outcome ◽  
History Of

Early pregnancy loss is a frustrating experience for both the patient and the physician. Approximately 5% of couples trying to conceive have 2 consecutive miscarriages and approximately 1% couples have 3 or more consecutive losses. Objective of this study is to determine whether therapy with dydrogesterone or Human chorionic Gonadotrophin hormone (HCG) in history of repeated pregnancy loss during the first trimester of pregnancy will improve pregnancy outcome. This is a prospective open comparative study.Women having early pregnancy presenting to a private clinic with history of early pregnancy loss, having no medical disorder were included in this study. Eligible subjects were randomised to receive either dydrogesterone 20mg daily or injection Human Chorionic Gonadotrophins (HCG) 5000 iu intramuscularly at 72 hours interval up to fourteen weeks of pregnancy or no additional treatment. Follow up of those patients were done with transabdominal ultrasonography. Hundred women were recruited. There was no statistically significant difference between the three groups with regard to pretreatment status. The continuing pregnancy success rate was higher in women treated with dydrogesterone (79.17%) and highest with Injection Human Chorionic, Gonadotrophin (86.36%) compared with women received no treatment (70%), (p=0.358). Hormonal support with either dydrogesterone or Human Chorionic Gonadotrophin may increase the chances of a successful pregnancy in women with a history of spontaneous abortion.Bang Med J (Khulna) 2015; 48 : 7-10

Ultrasonographically documented early pregnancy loss in an Asian elephant (Elephas maximus)

2010 ◽  
Vol 22 (7) ◽  
pp. 1159 ◽  
Author(s):  
Imke Lueders ◽  
Barbara Drews ◽  
Cheryl Niemuller ◽  
Charlie Gray ◽  
Peter Rich ◽  
...  
Keyword(s):  
Early Pregnancy ◽  
Pregnancy Loss ◽  
Fetal Loss ◽  
Normal Pregnancy ◽  
Uterine Horn ◽  
Asian Elephant ◽  
Early Pregnancy Loss ◽  
Early Pregnancy Failure ◽  
Embryonic Life ◽  
Embryonic Death

Early embryonic resorption or fetal loss is known to occur occasionally in captive elephants; however, this has mostly been reported anecdotally. The present study documents the case of a 24-year-old, multiparous Asian elephant cow that suffered embryonic death and resorption at around 18 weeks of gestation. From ovulation onwards, this female was sonographically examined 58 times. Blood was collected twice weekly for progestagen determination via enzyme immunoassay. On Day 42 after ovulation, a small quantity of fluid was detected in the uterine horn, which typically indicates the presence of a developing conceptus. Repeated inspections followed what appeared to be a normal pregnancy until Day 116. However, on Day 124, signs of embryonic life were absent. Progestagen concentrations started declining two weeks later, reaching baseline levels one month after embryonic death. Retrospectively, ultrasound examination revealed several abnormalities in the uterine horn. Besides an existing leiomyoma, multiple small cystic structures had formed in the endometrium at the implantation site and later in the placenta. These pathological findings were considered as possible contributors to the early pregnancy failure. PCR for endotheliotropic elephant herpes virus (EEHV) (which had occurred previously in the herd) as well as serology for other infectious organisms known to cause abortion in domestic animals did not yield any positive results. Although no definitive reason was found for this pregnancy to abort, this ultrasonographically and endocrinologically documented study of an early pregnancy loss provides important insights into the resorption process in Asian elephants.

Association of DNMT3B and DNMN3L Gene Polymorphisms with Early Pregnancy Loss

2019 ◽  
Vol 167 (4) ◽  
pp. 475-478
Author(s):  
M. M. Azova ◽  
A. A. Ahmed ◽  
A. Ait Aissa ◽  
M. L. Blagonravov
Keyword(s):  
Early Pregnancy ◽  
Gene Polymorphisms ◽  
Pregnancy Loss ◽  
Early Pregnancy Loss
Sign in / Sign up

Export Citation Format

Share Document