scholarly journals Kā raugs uzvedas, kad tam atņem būvelementus?

2021 ◽  
Author(s):  
Ernests Tomass Auziņš ◽  
Keyword(s):  
Ethanol Production ◽  
Building Block ◽  
De Novo ◽  
Building Blocks ◽  
Central Metabolism ◽  
De Novo Synthesis ◽  
Brewer’S Yeast ◽  
Glycerol Production ◽  
Brewer's Yeast ◽  
Insight Into

The study explored changes in carbon fluxes in the central metabolism of brewer’s yeast in the absence of building blocks such as adenine or nitrogen. These flows provide insight into changes in the central metabolism of brewer’s yeast. It was found that in the absence of a building block, the yeast mainly uses fermentation for growth, producing ethanol. Deletion of Δade1 in purine de novo synthesis reduces ethanol production, and decreased glycerol production in adenine starvation indicates a slowing of central metabolism.

scholarly journals Spent Brewer’s Yeast as a Source of Insoluble β-Glucans

2021 ◽  
Vol 22 (2) ◽  
pp. 825
Author(s):  
Ionut Avramia ◽  
Sonia Amariei
Keyword(s):  
Emulsion Stability ◽  
Extraction Process ◽  
Brewer’S Yeast ◽  
Brewer's Yeast ◽  
Brewing Process ◽  
Food Applications ◽  
Water Holding ◽  
Potential Food ◽  
Insight Into

In the brewing process, the consumption of resources and the amount of waste generated are high and due to a lot of organic compounds in waste-water, the capacity of natural regeneration of the environment is exceeded. Residual yeast, the second by-product of brewing is considered to have an important chemical composition. An approach with nutritional potential refers to the extraction of bioactive compounds from the yeast cell wall, such as β-glucans. Concerning the potential food applications with better textural characteristics, spent brewer’s yeast glucan has high emulsion stability and water-holding capacity fitting best as a fat replacer in different food matrices. Few studies demonstrate the importance and nutritional role of β-glucans from brewer’s yeast, and even less for spent brewer’s yeast, due to additional steps in the extraction process. This review focuses on describing the process of obtaining insoluble β-glucans (particulate) from spent brewer’s yeast and provides an insight into how a by-product from brewing can be converted to potential food applications.

De Novo Synthesis of l-Colitose and l-Rhodinose Building Blocks

2011 ◽  
Vol 77 (2) ◽  
pp. 870-877 ◽  
Author(s):  
Oliviana Calin ◽  
Rajan Pragani ◽  
Peter H. Seeberger
Keyword(s):  
De Novo ◽  
Building Blocks ◽  
De Novo Synthesis

A de novo Synthesis of Oxindoles from Cyclohexanone-Derived γ-Keto-ester Acceptors Using a Desaturative Amination–Cyclization Approach

Synthesis ◽  
2021 ◽  
Author(s):  
Henry P. Caldora ◽  
Sebastian Govaerts ◽  
Shashikant U. Dighe ◽  
Oliver J. Turner ◽  
Daniele Leonori
Keyword(s):  
Amino Acids ◽  
Primary Amine ◽  
De Novo ◽  
Building Blocks ◽  
De Novo Synthesis ◽  
Keto Ester ◽  
Mild Conditions ◽  
Blockbuster Drug

Here we report a desaturative approach for oxindole synthesis. This method uses simple γ-ester-containing cyclohexanones and primary amine building blocks as coupling partners. A dual photoredox–cobalt manifold is used to generate a secondary aniline that, upon heating, cyclizes with the pendent ester functionality. The process operates under mild conditions and was applied to the modification of several amino acids, the blockbuster drug mexiletine, as well as the formation of dihydroquinolinones.

Conceptual Synthesis of Compliance at a Single Point

2006 ◽  
Author(s):  
Charles Kim ◽  
Yong-Mo Moon ◽  
Sridhar Kota
Keyword(s):  
Building Block ◽  
Compliant Mechanism ◽  
Single Point ◽  
Geometry Optimization ◽  
Building Blocks ◽  
Kinematic Behavior ◽  
The Mathematical Model ◽  
Insight Into ◽  
Block Approach

In this paper, we investigate a methodology for the conceptual synthesis of compliance at a single point based on a building block approach. The methodology lays the foundation for more general compliant mechanism synthesis problems involving multiple points of interest (i.e. inputs and outputs). In the building block synthesis, the problem specifications are decomposed into related sub-problems if a single building block cannot perform the desired task. The sub-problems are tested against the library of building blocks until a suitable building block is determined. The synthesized design is composed of an assembly of the building blocks to provide the desired functionality. The building block approach is intuitive and provides key insight into how individual building blocks contribute to the overall function. We investigate the basic kinematic behavior of individual building blocks and relate this to the behavior of a design composed of building blocks. This serves to not only generate viable solutions but also to augment the understanding of the designer. Once a feasible concept is thus generated, known methods for size and geometry optimization may be employed to fine tune performance. The key enabler of the building block synthesis is the method of capturing kinematic behavior using Compliance Ellipsoids. The mathematical model of the compliance ellipsoids facilitates the characterization of the building blocks, transformation of problem specifications, decomposition into sub-problems, and the ability to search for alternate solutions. The compliance ellipsoids also give insight into how individual building blocks contribute to the overall kinematic function. The effectiveness and generality of the methodology are demonstrated through a synthesis example. Using only a limited set of building blocks, the methodology is capable of addressing generic kinematic problem specifications.

De Novo Synthesis of Aceric Acid and an Aceric Acid Building Block

2006 ◽  
Vol 71 (21) ◽  
pp. 8294-8297 ◽  
Author(s):  
Mattie S. M. Timmer ◽  
Bridget L. Stocker ◽  
Peter H. Seeberger
Keyword(s):  
Building Block ◽  
De Novo ◽  
De Novo Synthesis

A Building Block Approach to the Conceptual Synthesis of Compliant Mechanisms Utilizing Compliance and Stiffness Ellipsoids

2008 ◽  
Vol 130 (2) ◽  
Author(s):  
Charles J. Kim ◽  
Yong-Mo Moon ◽  
Sridhar Kota
Keyword(s):  
Building Block ◽  
Compliant Mechanisms ◽  
Compliant Mechanism ◽  
Single Point ◽  
Rapid Prototype ◽  
Building Blocks ◽  
Single Input Single Output ◽  
Kinematic Behavior ◽  
Insight Into ◽  
Block Approach

In this paper, we investigate a methodology for the conceptual synthesis of compliant mechanisms based on a building block approach. The building block approach is intuitive and provides key insight into how individual building blocks contribute to the overall function. We investigate the basic kinematic behavior of individual building blocks and relate this to the behavior of a design composed of building blocks. This serves to not only generate viable solutions but also to augment the understanding of the designer. Once a feasible concept is thus generated, known methods for size and geometry optimization may be employed to fine-tune performance. The key enabler of the building block synthesis is the method of capturing kinematic behavior using compliance ellipsoids. The mathematical model of the compliance ellipsoids facilitates the characterization of the building blocks, transformation of problem specifications, decomposition into subproblems, and the ability to search for alternate solutions. The compliance ellipsoids also give insight into how individual building blocks contribute to the overall kinematic function. The effectiveness and generality of the methodology are demonstrated through two synthesis examples. Using only a limited set of building blocks, the methodology is capable of addressing generic kinematic problem specifications for compliance at a single point and for a single-input, single-output compliant mechanism. A rapid prototype of the latter demonstrates the validity of the conceptual solution.

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